Scholar Rock Holding Corporation (NASDAQ:SRRK) Accelerates Regulatory Pathway With BLA Resubmission, Setting Up Near-Term Catalysts

Pipeline momentum and a formal BLA resubmission position the company for regulatory catalysts while a substantial cash position supports near-term program execution.

Recent News

On March 31, 2026 Scholar Rock resubmitted its Biologics License Application (BLA) for apitegromab to the U.S. FDA, including an additional fill‑finish facility in the resubmission after alignment with FDA during a Type C meeting.

On May 7, 2026 the company reported first-quarter 2026 financial results and reiterated readiness for a U.S. launch pending approval, noting a PDUFA action date targeted for late September 2026.

Technical Analysis

ADX sits at 19.26, indicating no durable trend in place; directional movement indicators show recent bearish role‑changes: DI+ registered a peak-and-reversal, signaling bearish pressure as DI+ declines, while DI- experienced a dip-and-reversal, signaling increasing bearish influence.

MACD at 0.33 lies below its signal line at 0.39 and the MACD trend shows a peak-and-reversal, which denotes bearish momentum and a failure of recent upside momentum to sustain itself.

MRO equals 22.77 and trends downward; the positive value indicates price currently exceeds the oscillator’s target and implies downward pressure, while the decreasing MRO trend suggests that that over-target pressure has begun to ease.

RSI near 52 with a peak-and-reversal indicates recent momentum has topped and rotated lower from a short-term peak, consistent with the bearish shift in MACD and the directional indicators.

Price sits at $47.72, below the 12‑day EMA ($48.24) and the 20‑day average ($48.21) but comfortably above the 200‑day average ($40.82). Short‑term moving averages and EMAs show peak-and-reversal behavior, implying short-term weakness against a longer-term uptrend baseline. Bollinger bands place price inside the 1× band range ($46.64–$49.78) and nearer the lower band, reflecting limited downside room within the short-term banded range.

Volume measures run below recent averages (current session ~1.03M vs. 10‑day avg ~1.23M and 50/200‑day averages higher), indicating muted participation behind the latest moves; 42‑day beta of 1.79 implies elevated short‑term volatility relative to the one‑year beta of 1.23.

 


Fundamental Analysis

Scholar Rock reported EPS of -$0.83 versus an estimate of -$0.80, a negative EPS surprise of -3.75%. Operating and net results remain loss‑making: EBIT -$103.2M and net income -$105.51M, with R&D at $51.8M reflecting active pipeline investment.

Balance sheet strength stands out: cash and short‑term investments total $479.9M and the current ratio measures 863.95%, providing liquidity that supports development and potential near‑term commercial readiness. Free cash flow remains negative at -$82.17M and operating cash flow at -$106.26M, indicating ongoing cash burn from operations despite the strong cash buffer.

Leverage metrics show total debt of $205.67M with debt-to-equity of 74.52% and debt-to-assets of 38.43%, levels that reflect the financing of clinical-stage operations while leaving headroom relative to the company’s cash resources. Interest expense remains modest at $2.30M, and interest coverage reflects negative operating results.

Valuation ratios present stretched multiples: price-to-book at 19.89 sits above the industry peer mean of 7.56 and the industry peer median of 5.61 while remaining below the industry peer high of 20.61; price-to-earnings is negative given losses. Free cash flow yield registers negative at -1.50%, and WMDST values the stock as over‑valued on these fundamentals relative to intrinsic assumptions.

Quarter-over-quarter and year-over-year dynamics: asset growth accelerated ~32.40% YoY, current ratio rose ~24.31% QoQ, and return on equity improved QoQ by +3.16 percentage points year-over-year but remains deeply negative at -38.226% on a trailing basis—signaling early‑stage operational leverage that has yet to convert to profitability.

MOST-RECENT QUARTERLY REPORT
REPORT PERIOD ENDING: 2026-03-31
REPORT DATE: 2026-05-07
NEXT REPORT DATE: 2026-08-06
CASH FLOW  Begin Period Cash Flow 327.3 M
 Operating Cash Flow -106.26 M
 Capital Expenditures -68.00 K
 Change In Working Capital 84.0 K
 Dividends Paid
 Cash Flow Delta 107.0 M
 End Period Cash Flow 434.4 M
 
INCOME STATEMENT REVENUE
 Total Revenue
 Forward Revenue
COSTS
 Cost Of Revenue
 Depreciation 335.0 K
 Depreciation and Amortization 335.0 K
 Research and Development 51.8 M
 Total Operating Expenses 102.0 M
PROFITABILITY
 Gross Profit
 EBITDA -102.87 M
 EBIT -103.21 M
 Operating Income -102.02 M
 Interest Income 2.9 M
 Interest Expense 2.3 M
 Net Interest Income 633.0 K
 Income Before Tax -105.51 M
 Tax Provision
 Tax Rate
 Net Income -105.51 M
 Net Income From Continuing Operations -105.51 M
EARNINGS
 EPS Estimate -0.80
 EPS Actual -0.83
 EPS Difference -0.03
 EPS Surprise -3.75 %
 Forward EPS -0.60
 
BALANCE SHEET ASSETS
 Total Assets 535.3 M
 Intangible Assets
 Net Tangible Assets 276.0 M
 Total Current Assets 515.3 M
 Cash and Short-Term Investments 479.9 M
 Cash 430.5 M
 Net Receivables
 Inventory
 Long-Term Investments 3.8 M
LIABILITIES
 Accounts Payable 9.2 M
 Short-Term Debt
 Total Current Liabilities 59.6 M
 Net Debt
 Total Debt 205.7 M
 Total Liabilities 259.2 M
EQUITY
 Total Equity 276.0 M
 Retained Earnings -1.41 B
VALUATION & PER-SHARE METRICS EQUITY & PER-SHARE METRICS
 Book Value Per-Share 2.32
 Shares Outstanding 119.104 M
 Revenue Per-Share
VALUATION
 Market Capitalization 5.5 B
 Enterprise Value 5.2 B
 Enterprise Multiple -50.71
Enterprise Multiple QoQ -1.084 %
Enterprise Multiple YoY 38.292 %
Enterprise Multiple IPRWA high: 75.51
median: 33.88
mean: 9.231
SRRK: -50.71
low: -128.217
 EV/R
CAPITAL STRUCTURE
 Asset To Equity 1.939
 Asset To Liability 2.065
 Debt To Capital 0.427
 Debt To Assets 0.384
Debt To Assets QoQ 42.626 %
Debt To Assets YoY 148.015 %
Debt To Assets IPRWA high: 1.112
SRRK: 0.384
mean: 0.248
median: 0.113
low: 0.0
 Debt To Equity 0.745
Debt To Equity QoQ 67.954 %
Debt To Equity YoY 268.581 %
Debt To Equity IPRWA high: 1.864
SRRK: 0.745
mean: 0.29
median: 0.103
low: -1.28
PRICE-BASED VALUATION
 Price To Book (P/B) 19.894
Price To Book QoQ 2.377 %
Price To Book YoY 99.558 %
Price To Book IPRWA high: 20.609
SRRK: 19.894
mean: 7.556
median: 5.613
low: -11.267
 Price To Earnings (P/E) -55.545
Price To Earnings QoQ 11.136 %
Price To Earnings YoY 13.396 %
Price To Earnings IPRWA high: 74.242
mean: -1.285
median: -14.354
SRRK: -55.545
low: -121.28
 PE/G Ratio 9.776
 Price To Sales (P/S)
Price To Sales QoQ
Price To Sales YoY
Price To Sales IPRWA
FORWARD MULTIPLES
Forward P/E -72.663
Forward PE/G 12.788
Forward P/S
EFFICIENCY OPERATIONAL
 Operating Leverage
ASSET & SALES
 Asset Turnover Ratio
Asset Turnover Ratio QoQ
Asset Turnover Ratio YoY
Asset Turnover Ratio IPRWA
 Receivables Turnover
Receivables Turnover Ratio QoQ
Receivables Turnover Ratio YoY
Receivables Turnover Ratio IPRWA
 Inventory Turnover
Inventory Turnover Ratio QoQ
Inventory Turnover Ratio YoY
Inventory Turnover Ratio IPRWA
 Days Sales Outstanding (DSO)
CASH CYCLE
 Cash Conversion Cycle Days (CCC)
Cash Conversion Cycle Days QoQ
Cash Conversion Cycle Days YoY
Cash Conversion Cycle Days IPRWA high: 499.798
mean: 219.741
median: 208.031
SRRK: 0
low: -303.652
CAPITAL DEPLOYMENT
 Cash Conversion Ratio
 CapEx To Revenue
 CapEx To Depreciation -0.203
 
CAPITAL, LIQUIDITY & COVERAGE CAPITAL STRUCTURE
 Total Capital 472.6 M
 Net Invested Capital 472.6 M
 Invested Capital 472.6 M
 Net Tangible Assets 276.0 M
 Net Working Capital 455.6 M
LIQUIDITY
 Cash Ratio 8.047
 Current Ratio 8.639
Current Ratio QoQ 24.314 %
Current Ratio YoY -15.737 %
Current Ratio IPRWA high: 32.587
SRRK: 8.639
mean: 5.601
median: 3.565
low: 0.05
 Quick Ratio
Quick Ratio QoQ
Quick Ratio YoY
Quick Ratio IPRWA
COVERAGE & LEVERAGE
 Debt To EBITDA -1.999
 Cost Of Debt 1.463 %
 Interest Coverage Ratio -44.834
Interest Coverage Ratio QoQ 28.472 %
Interest Coverage Ratio YoY -34.281 %
Interest Coverage Ratio IPRWA high: 604.866
mean: 14.964
median: 3.938
SRRK: -44.834
low: -1946.175
 Operating Cash Flow Ratio -1.782
TIMING / LIQUIDITY
 Days Payables Outstanding (DPO)
DIVIDENDS
 Dividend Coverage Ratio
 Dividend Payout Ratio
 Dividend Rate
 Dividend Yield
PERFORMANCE GROWTH
 Asset Growth Rate 32.399 %
 Revenue Growth
Revenue Growth QoQ
Revenue Growth YoY
Revenue Growth IPRWA
 Earnings Growth -5.682 %
Earnings Growth QoQ 155.716 %
Earnings Growth YoY -157.767 %
Earnings Growth IPRWA high: 200.0 %
median: -4.762 %
SRRK: -5.682 %
mean: -10.009 %
low: -250.0 %
MARGINS
 Gross Margin
Gross Margin QoQ
Gross Margin YoY
Gross Margin IPRWA
 EBIT Margin
EBIT Margin QoQ
EBIT Margin YoY
EBIT Margin IPRWA
 Return On Sales (ROS)
Return On Sales QoQ
Return On Sales YoY
Return On Sales IPRWA
CASH FLOW
 Free Cash Flow (FCF) -82.17 M
 Free Cash Flow Yield -1.496 %
Free Cash Flow Yield QoQ -5.496 %
Free Cash Flow Yield YoY -41.009 %
Free Cash Flow Yield IPRWA high: 11.709 %
median: 0.11 %
mean: -0.484 %
SRRK: -1.496 %
low: -45.34 %
 Free Cash Growth 8.793 %
Free Cash Growth QoQ -6.952 %
Free Cash Growth YoY -85.19 %
Free Cash Growth IPRWA high: 253.163 %
median: 23.728 %
mean: 18.355 %
SRRK: 8.793 %
low: -249.577 %
 Free Cash To Net Income 0.779
 Cash Flow Margin
 Cash Flow To Earnings 1.007
VALUE & RETURNS
 Economic Value Added
 Return On Assets (ROA) -22.46 %
Return On Assets QoQ 0.736 %
Return On Assets YoY 32.625 %
Return On Assets IPRWA high: 38.074 %
median: 0.896 %
mean: -2.812 %
SRRK: -22.46 %
low: -67.241 %
 Return On Capital Employed (ROCE) -21.7 %
 Return On Equity (ROE) -0.382
Return On Equity QoQ 3.16 %
Return On Equity YoY 59.781 %
Return On Equity IPRWA high: 0.797
median: 0.022
mean: -0.004
SRRK: -0.382
low: -1.109
 DuPont ROE
 Return On Invested Capital (ROIC)
Return On Invested Capital QoQ
Return On Invested Capital YoY
Return On Invested Capital IPRWA

Six-Week Outlook

Near-term momentum favors consolidation with a downside tilt: short-term indicators (MACD below its signal, DI+ peak-and-reversal, RSI peak-and-reversal) point to reduced upside momentum and higher probability of range contraction around recent levels. The balance sheet and the resubmitted BLA remove certain binary supply risks, but the primary regulatory milestone (PDUFA action scheduled for late September 2026) sits outside the six‑week window and thus offers limited immediate directional pull.

Expect price action to be driven by short-term technical confirmations and volume pick‑up: a sustained MACD‑signal separation or a reversal back to increasing DI+ would materially change the near-term bias; absent that, price likely remains within the recent band defined by the lower Bollinger boundary and the short-term averages, with volatility elevated relative to the one‑year baseline.

Monitor participation metrics and any operational updates tied to manufacturing or supply that could reintroduce catalyst‑driven moves; until then, technicals and cash position imply capacity to execute while valuation metrics retain an over‑valued designation under WMDST’s current framework.

About Scholar Rock Holding Corporation

Scholar Rock Holding Corporation (NASDAQ:SRRK) develops innovative biopharmaceutical solutions targeting serious diseases influenced by protein growth factor signaling. The company advances Apitegromab, a myostatin activation inhibitor, currently undergoing Phase 3 clinical trials aimed at treating spinal muscular atrophy. Scholar Rock also progresses SRK-181, which has completed Phase 1 trials, targeting cancers resistant to checkpoint inhibitor therapies, including anti-PD-1 and anti-PD-L1 antibody therapies. Their pipeline includes potential treatments for neuromuscular disorders, cardiometabolic disorders, cancer, fibrosis, and iron-restricted anemia. Founded in 2012, Scholar Rock operates from its headquarters in Cambridge, Massachusetts, driving forward the development of novel therapeutic candidates to address unmet medical needs.



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