IDEAYA Biosciences, Inc (NASDAQ:IDYA) Reclaims Clinical Programs And Prepares Near-Term Data Catalysts

Ideaya moves into a decisive data-and-programs phase: regained program rights and multiple near-term clinical updates concentrate catalysts while balance-sheet strength funds execution.

Recent News

Jan. 11, 2026: At the J.P. Morgan conference Ideaya outlined 2026 objectives, including initiation of the OptimUM-11 adjuvant trial in collaboration with Servier in Q2 2026. Feb. 17, 2026: the company issued a corporate update confirming the return of two programs from GlaxoSmithKline and reiterated a multi-year cash runway. March 9, 2026: Ideaya announced first-patient-in for the Phase 1 IDE892 PRMT5 program and outlined MTAP/CDKN2A pipeline milestones. March 18, 2026: the company scheduled preclinical presentations for IDE034, IDE574 and IDE892 at AACR 2026.

Technical Analysis

ADX at 13.17 signals no clear trend; low trend strength suggests price action may remain range-bound absent a catalyst, tempering conviction around valuation-driven moves.

Directional indicators show DI+ dip-and-reversal and DI− peak-and-reversal; both patterns imply a developing bullish directional split as DI+ increases and DI− declines, which supports a near-term upward bias versus the current valuation.

MACD sits slightly below zero at −0.25 but shows a dip-and-reversal and has crossed just above its signal line (MACD signal −0.26); that combination indicates bullish momentum emergence despite the MACD’s negative absolute value.

MRO at 19.23 (positive and increasing) indicates the current price sits above the model target and therefore contains built-in potential for downside pressure if momentum stalls; the increasing MRO strengthens that potential.

RSI near neutral at 49.22 with a peak-and-reversal pattern points to a recent toping action that introduces short-term bearish friction to any rally, making near-term follow-through less certain.

Price structure shows mixed internals: close at $32.34 sits above the 200-day average ($29.53) and 20-day average ($32.24) but below the 50-day average ($32.77); the 12-day EMA exhibits a dip-and-reversal. This footprint supports guarded upside while indicating resistance around the 50-day average.

Bollinger bands remain narrow (upper ~ $33.44, lower ~ $31.04) and Ichimoku lines cluster near the current price, signaling low volatility and a consolidation regime that could resolve with any of the cited clinical or corporate catalysts.

Volume on the latest session (553,592) sits below 10/50/200-day averages, suggesting follow-through lacks conviction and that moves may require volume expansion to validate directional bias.

 


Fundamental Analysis

Revenue totaled $10.9M for the period ending 2025-12-31 with YoY revenue growth of −94.77% and QoQ change of −103.30%, reflecting a steep decline in reported collaboration or product-related income versus prior periods.

Operating metrics show an EBIT of −$94.6M and an EBIT margin of −8.70%, which compares unfavorably with the industry peer mean EBIT margin of −0.87%; the margin deterioration QoQ was −17.66 percentage points while YoY moved −0.58 percentage points.

EPS finished at −$0.94 versus an estimate of −$0.95, producing an EPS surprise of +1.05%.

R&D spend reached $86.6M, approximately 796% of total revenue, underscoring a development-stage cost base focused on pipeline progression rather than near-term commercial sales.

Liquidity and leverage present clear contrasts: cash and short-term investments total $639.4M and the company reports a cash ratio of 10.87 and current ratio of 11.34, while total debt stands at $27.9M (debt-to-assets ~2.52%). The corporate update and filings state this position supports a multi-year runway into 2030.

Profitability and returns remain negative: return on assets −7.26% and return on equity −8.14%; operating and free-cash-flow trends show negative operating cash flow (−$90.5M) and free cash flow (−$90.8M), with free-cash-flow yield at −3.11%.

Market multiples show a mixed picture: price-to-book ~2.85x (below the industry peer mean of ~5.22x), enterprise-value-to-revenue metrics and PS ratios read elevated (PS ~268.3x), and the WMDST valuation assessment classifies the stock as over-valued given the combination of current price, limited near-term revenue and material development spending.

MOST-RECENT QUARTERLY REPORT
REPORT PERIOD ENDING: 2025-12-31
REPORT DATE: 2026-02-17
NEXT REPORT DATE: 2026-05-19
CASH FLOW  Begin Period Cash Flow 299.7 M
 Operating Cash Flow -90.50 M
 Capital Expenditures -333.00 K
 Change In Working Capital -18.69 M
 Dividends Paid
 Cash Flow Delta -185.89 M
 End Period Cash Flow 113.8 M
 
INCOME STATEMENT REVENUE
 Total Revenue 10.9 M
 Forward Revenue 2.4 M
COSTS
 Cost Of Revenue
 Depreciation 1.2 M
 Depreciation and Amortization 1.2 M
 Research and Development 86.6 M
 Total Operating Expenses 105.4 M
PROFITABILITY
 Gross Profit
 EBITDA -93.37 M
 EBIT -94.57 M
 Operating Income -94.57 M
 Interest Income 11.3 M
 Interest Expense
 Net Interest Income 11.3 M
 Income Before Tax -83.27 M
 Tax Provision
 Tax Rate
 Net Income -83.27 M
 Net Income From Continuing Operations -83.27 M
EARNINGS
 EPS Estimate -0.95
 EPS Actual -0.94
 EPS Difference 0.01
 EPS Surprise 1.053 %
 Forward EPS -0.85
 
BALANCE SHEET ASSETS
 Total Assets 1.1 B
 Intangible Assets
 Net Tangible Assets 1.0 B
 Total Current Assets 666.7 M
 Cash and Short-Term Investments 639.4 M
 Cash 112.8 M
 Net Receivables
 Inventory
 Long-Term Investments 1.0 M
LIABILITIES
 Accounts Payable 17.6 M
 Short-Term Debt
 Total Current Liabilities 58.8 M
 Net Debt
 Total Debt 27.9 M
 Total Liabilities 86.4 M
EQUITY
 Total Equity 1.0 B
 Retained Earnings -736.54 M
VALUATION & PER-SHARE METRICS EQUITY & PER-SHARE METRICS
 Book Value Per-Share 11.65
 Shares Outstanding 87.797 M
 Revenue Per-Share 0.12
VALUATION
 Market Capitalization 2.9 B
 Enterprise Value 2.3 B
 Enterprise Multiple -24.705
Enterprise Multiple QoQ -268.575 %
Enterprise Multiple YoY 127.385 %
Enterprise Multiple IPRWA high: 79.485
median: 58.093
mean: 19.945
IDYA: -24.705
low: -114.076
 EV/R 212.101
CAPITAL STRUCTURE
 Asset To Equity 1.084
 Asset To Liability 12.841
 Debt To Capital 0.027
 Debt To Assets 0.025
Debt To Assets QoQ 9.439 %
Debt To Assets YoY 47.566 %
Debt To Assets IPRWA high: 1.032
mean: 0.121
IDYA: 0.025
median: 0.003
low: 0.0
 Debt To Equity 0.027
Debt To Equity QoQ 9.379 %
Debt To Equity YoY 50.773 %
Debt To Equity IPRWA high: 1.588
mean: 0.137
IDYA: 0.027
median: 0.005
low: -0.957
PRICE-BASED VALUATION
 Price To Book (P/B) 2.853
Price To Book QoQ 31.777 %
Price To Book YoY 36.34 %
Price To Book IPRWA high: 19.432
median: 6.164
mean: 5.221
IDYA: 2.853
low: -10.511
 Price To Earnings (P/E) -35.361
Price To Earnings QoQ -274.394 %
Price To Earnings YoY 105.651 %
Price To Earnings IPRWA high: 75.085
mean: -0.659
median: -16.183
IDYA: -35.361
low: -119.903
 PE/G Ratio 0.207
 Price To Sales (P/S) 268.324
Price To Sales QoQ 2258.847 %
Price To Sales YoY -15.249 %
Price To Sales IPRWA high: 773.807
IDYA: 268.324
mean: 48.514
median: 20.207
low: -75.758
FORWARD MULTIPLES
Forward P/E -38.388
Forward PE/G 0.225
Forward P/S 1222.354
EFFICIENCY OPERATIONAL
 Operating Leverage 1.975
ASSET & SALES
 Asset Turnover Ratio 0.009
Asset Turnover Ratio QoQ -94.922 %
Asset Turnover Ratio YoY 60.135 %
Asset Turnover Ratio IPRWA high: 0.406
mean: 0.117
median: 0.109
IDYA: 0.009
low: -0.066
 Receivables Turnover
Receivables Turnover Ratio QoQ
Receivables Turnover Ratio YoY
Receivables Turnover Ratio IPRWA
 Inventory Turnover
Inventory Turnover Ratio QoQ
Inventory Turnover Ratio YoY
Inventory Turnover Ratio IPRWA
 Days Sales Outstanding (DSO)
CASH CYCLE
 Cash Conversion Cycle Days (CCC)
Cash Conversion Cycle Days QoQ
Cash Conversion Cycle Days YoY
Cash Conversion Cycle Days IPRWA high: 937.301
mean: 237.323
median: 192.562
IDYA: 0
low: -463.897
CAPITAL DEPLOYMENT
 Cash Conversion Ratio 0.018
 CapEx To Revenue -0.031
 CapEx To Depreciation -0.278
 
CAPITAL, LIQUIDITY & COVERAGE CAPITAL STRUCTURE
 Total Capital 1.0 B
 Net Invested Capital 1.0 B
 Invested Capital 1.0 B
 Net Tangible Assets 1.0 B
 Net Working Capital 607.9 M
LIQUIDITY
 Cash Ratio 10.871
 Current Ratio 11.336
Current Ratio QoQ -8.893 %
Current Ratio YoY -24.279 %
Current Ratio IPRWA high: 27.397
IDYA: 11.336
mean: 3.901
median: 2.827
low: 0.027
 Quick Ratio
Quick Ratio QoQ
Quick Ratio YoY
Quick Ratio IPRWA
COVERAGE & LEVERAGE
 Debt To EBITDA -0.299
 Cost Of Debt 71.803 %
 Interest Coverage Ratio -3.773
Interest Coverage Ratio QoQ -187.2 %
Interest Coverage Ratio YoY -34.389 %
Interest Coverage Ratio IPRWA high: 671.002
mean: 40.601
median: 3.11
IDYA: -3.773
low: -1571.333
 Operating Cash Flow Ratio -1.41
TIMING / LIQUIDITY
 Days Payables Outstanding (DPO)
DIVIDENDS
 Dividend Coverage Ratio
 Dividend Payout Ratio
 Dividend Rate
 Dividend Yield
PERFORMANCE GROWTH
 Asset Growth Rate -6.397 %
 Revenue Growth -94.767 %
Revenue Growth QoQ -103.303 %
Revenue Growth YoY
Revenue Growth IPRWA high: 443.939 %
mean: 13.329 %
median: 2.844 %
IDYA: -94.767 %
low: -242.388 %
 Earnings Growth -170.677 %
Earnings Growth QoQ -32.038 %
Earnings Growth YoY -215.063 %
Earnings Growth IPRWA high: 178.788 %
median: -14.286 %
mean: -16.484 %
IDYA: -170.677 %
low: -202.0 %
MARGINS
 Gross Margin
Gross Margin QoQ
Gross Margin YoY
Gross Margin IPRWA
 EBIT Margin -869.529 %
EBIT Margin QoQ -1766.339 %
EBIT Margin YoY -57.772 %
EBIT Margin IPRWA high: 3501.566 %
median: 21.25 %
mean: -86.639 %
IDYA: -869.529 %
low: -7602.597 %
 Return On Sales (ROS) -869.529 %
Return On Sales QoQ -1766.339 %
Return On Sales YoY -57.772 %
Return On Sales IPRWA high: 1116.376 %
median: 27.297 %
mean: -92.365 %
IDYA: -869.529 %
low: -7602.597 %
CASH FLOW
 Free Cash Flow (FCF) -90.83 M
 Free Cash Flow Yield -3.112 %
Free Cash Flow Yield QoQ -151.746 %
Free Cash Flow Yield YoY -43.817 %
Free Cash Flow Yield IPRWA high: 21.452 %
median: 0.303 %
mean: 0.169 %
IDYA: -3.112 %
low: -50.821 %
 Free Cash Growth -163.887 %
Free Cash Growth QoQ -49.601 %
Free Cash Growth YoY -211.457 %
Free Cash Growth IPRWA high: 177.21 %
median: -24.462 %
mean: -30.957 %
IDYA: -163.887 %
low: -197.482 %
 Free Cash To Net Income 1.091
 Cash Flow Margin -762.459 %
 Cash Flow To Earnings 0.996
VALUE & RETURNS
 Economic Value Added
 Return On Assets (ROA) -7.259 %
Return On Assets QoQ -167.765 %
Return On Assets YoY -34.159 %
Return On Assets IPRWA high: 33.814 %
median: 1.099 %
mean: -2.705 %
IDYA: -7.259 %
low: -59.608 %
 Return On Capital Employed (ROCE) -9.002 %
 Return On Equity (ROE) -0.081
Return On Equity QoQ -174.558 %
Return On Equity YoY -33.829 %
Return On Equity IPRWA high: 0.809
median: 0.039
mean: 0.001
IDYA: -0.081
low: -1.16
 DuPont ROE -7.874 %
 Return On Invested Capital (ROIC)
Return On Invested Capital QoQ
Return On Invested Capital YoY
Return On Invested Capital IPRWA

Six-Week Outlook

Near-term price action looks catalyst-driven and range-bound. Technical reads indicate nascent bullish momentum (DI+/MACD) but limited trend strength (ADX) and subdued volume; the MRO’s positive reading warns the stock trades above the model target, increasing the likelihood of pullbacks should momentum fade. Fundamental anchors—the returned programs, first-patient-in for IDE892, and scheduled AACR presentations—create discrete dates that can compress volatility into directional moves. For swing-oriented participants, anticipate consolidation that could resolve around clinical-readout or program-ownership updates; volume expansion accompanying any breakout will signal higher conviction, while failure to expand volume would preserve the current consolidation and maintain valuation risk given WMDST’s over-valued designation.

About IDEAYA Biosciences, Inc.

Ideaya Biosciences, Inc. (NASDAQ:IDYA) develops precision medicine solutions in oncology, with a particular emphasis on synthetic lethality, an innovative approach in cancer therapy. Based in South San Francisco, California, the company targets genetically defined patient populations through its pipeline of therapeutic candidates. Notable among these are IDE196, a Phase 2/3 protein kinase C inhibitor for cancers with GNAQ or GNA11 mutations, and IDE397, a Phase 1/2 inhibitor addressing solid tumors with specific gene deletions. Ideaya collaborates with industry leaders such as GlaxoSmithKline, Pfizer, and Novartis, which enhances its drug discovery and development capabilities. The company employs advanced technologies, including the DECIPHER dual CRISPR library and INQUIRE chemical library, to identify new therapeutic targets and biomarkers. Ideaya’s approach to cancer treatment involves not only drug development but also a deep understanding of the genetic and molecular mechanisms of cancer. This strategy aims to provide more effective, personalized therapies, offering new treatment possibilities for patients facing difficult cancer types.



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