CRISPR Therapeutics AG (NASDAQ:CRSP) Issues Convertible Debt, Drives Near-Term Downside Pressure

Convertible-note financing increases liquidity but coincides with weakening price action and a WMDST valuation that classifies the stock as over-valued. Near-term momentum and mean-reversion dynamics create pressure on the share price despite accelerating revenue growth.

Recent News

On March 11, 2026 the company priced $550 million of convertible senior notes due 2031 in a private offering to qualified institutional buyers, with potential redemption features tied to share performance. On February 3, 2026 an analyst update raised the average one‑year price target, revising consensus toward a higher level. Analyst commentary and media coverage through early March highlighted the convertible offering as the proximate driver of the recent intraday selloffs, and noted prospective interest‑cost and dilution mechanics tied to the notes. A December 29, 2025 analyst action signaled divergent views across the street heading into year‑end.

Technical Analysis

ADX at 16.56 indicates no established trend; the market currently lacks trending conviction and remains range-prone under present momentum conditions.

Directional indicators show DI+ 22.05 with a decreasing trend and DI− 20.07 with a dip-and-reversal; both conditions point toward bearish directional pressure as DI+ weakens while DI− registers a reversal.

MACD sits at 0.02 and trends downward beneath its signal line at 0.70, confirming bearish momentum and a lack of bullish momentum crossover at present.

MRO at 17.18 registers positive and decreasing; price sits above the model target, implying pressure for price to revert lower toward the target as momentum eases.

RSI 48.09 with a peak‑and‑reversal pattern signals momentum rollover from recent highs rather than an immediate oversold entry; momentum failed to sustain above neutral band and turned lower.

Price sits below the 20‑day average ($56.49) and the 200‑day average ($55.58); the 12‑day EMA shows a peak‑and‑reversal, so short‑term averages remain above current price and act as resistance levels on any bounce attempt.

Bollinger placement places the close ($48.87) below the 1x lower band ($52.07) and close to the 2x lower band ($47.65), indicating downside volatility expansion and compression away from the short‑term mean.

Short‑term beta (42‑day) of 2.0 and above‑average volume today relative to 10‑ and 50‑day averages point to amplified downside sensitivity during market moves; higher trading volume accompanies the recent selling pressure.

 


Fundamental Analysis

Profitability metrics reflect continued investment and operating losses: operating income (EBIT) stands at −$154,764,000 and net income at −$130,613,000. EPS actual printed at −$1.37 versus an estimate of −$1.23, an EPS miss of −$0.14 or −11.38% on the estimate. The company reports negative PE and forward PE ratios (PE −39.76; forward PE −61.54), consistent with ongoing unprofitability.

Revenue growth accelerated strongly: YoY revenue growth at 66.70% with QoQ growth also positive (16.73% QoQ). Research and development remains a material expense at $83,526,000 as development and commercialization of gene‑edited therapies advances.

Liquidity and balance‑sheet metrics display substantial cash resources: cash and short‑term investments total $1,975,828,000 and total current assets exceed current liabilities by a wide margin (current ratio 13.32, cash ratio 13.25). Leverage remains low (debt to assets 9.13%, debt to equity 10.76%). Those cash reserves contrast with negative operating cash flow of −$125,612,000 and free cash flow of −$93,070,000, supporting continued funding of development programs and near‑term obligations while burn persists.

Valuation metrics show mixed signals: P/B ratio 2.72 sits below the industry peer mean of 8.09 and below the industry peer median of 6.16, indicating a lower book valuation relative to peer averages; balance‑sheet strength underpins that relative P/B placement. Enterprise multiple sits negative (−23.17) and the WMDST valuation flags the stock as over-valued, placing market price above the model’s justified level given losses and forward estimates.

Operationally, cash conversion cycle and working capital figures remain favorable (cash conversion cycle −18.32 days; net working capital $1,836,551,000), supporting clinical program funding and commercial rollouts without immediate liquidity stress, but profitability and cash generation remain future objectives rather than current strengths.

MOST-RECENT QUARTERLY REPORT
REPORT PERIOD ENDING: 2025-12-31
REPORT DATE: 2026-02-12
NEXT REPORT DATE: 2026-05-14
CASH FLOW  Begin Period Cash Flow 298.0 M
 Operating Cash Flow -125.61 M
 Capital Expenditures -517.00 K
 Change In Working Capital 22.6 M
 Dividends Paid
 Cash Flow Delta 61.1 M
 End Period Cash Flow 359.1 M
 
INCOME STATEMENT REVENUE
 Total Revenue
 Forward Revenue
COSTS
 Cost Of Revenue 53.7 M
 Depreciation 5.7 M
 Depreciation and Amortization 5.7 M
 Research and Development 83.5 M
 Total Operating Expenses 154.8 M
PROFITABILITY
 Gross Profit -53.70 M
 EBITDA -149.10 M
 EBIT -154.76 M
 Operating Income -154.76 M
 Interest Income
 Interest Expense
 Net Interest Income
 Income Before Tax -130.00 M
 Tax Provision 614.0 K
 Tax Rate 8.5 %
 Net Income -130.61 M
 Net Income From Continuing Operations -130.61 M
EARNINGS
 EPS Estimate -1.23
 EPS Actual -1.37
 EPS Difference -0.14
 EPS Surprise -11.382 %
 Forward EPS -1.05
 
BALANCE SHEET ASSETS
 Total Assets 2.3 B
 Intangible Assets
 Net Tangible Assets 1.9 B
 Total Current Assets 2.0 B
 Cash and Short-Term Investments 2.0 B
 Cash 347.6 M
 Net Receivables
 Inventory
 Long-Term Investments 32.0 M
LIABILITIES
 Accounts Payable 11.1 M
 Short-Term Debt
 Total Current Liabilities 149.1 M
 Net Debt
 Total Debt 206.7 M
 Total Liabilities 343.4 M
EQUITY
 Total Equity 1.9 B
 Retained Earnings -1.95 B
VALUATION & PER-SHARE METRICS EQUITY & PER-SHARE METRICS
 Book Value Per-Share 20.04
 Shares Outstanding 95.894 M
 Revenue Per-Share
VALUATION
 Market Capitalization 5.2 B
 Enterprise Value 3.5 B
 Enterprise Multiple -23.168
Enterprise Multiple QoQ -27.364 %
Enterprise Multiple YoY -32.641 %
Enterprise Multiple IPRWA high: 170.423
median: 58.093
mean: 34.121
CRSP: -23.168
low: -160.468
 EV/R
CAPITAL STRUCTURE
 Asset To Equity 1.179
 Asset To Liability 6.596
 Debt To Capital 0.097
 Debt To Assets 0.091
Debt To Assets QoQ -2.884 %
Debt To Assets YoY -8.52 %
Debt To Assets IPRWA high: 1.032
mean: 0.267
median: 0.191
CRSP: 0.091
low: 0.0
 Debt To Equity 0.108
Debt To Equity QoQ -2.324 %
Debt To Equity YoY -7.082 %
Debt To Equity IPRWA high: 1.62
mean: 0.413
median: 0.109
CRSP: 0.108
low: -1.217
PRICE-BASED VALUATION
 Price To Book (P/B) 2.718
Price To Book QoQ -9.831 %
Price To Book YoY 40.597 %
Price To Book IPRWA high: 20.409
mean: 8.089
median: 6.164
CRSP: 2.718
low: -10.511
 Price To Earnings (P/E) -39.76
Price To Earnings QoQ -24.388 %
Price To Earnings YoY -59.84 %
Price To Earnings IPRWA high: 177.393
median: 68.97
mean: 41.481
CRSP: -39.76
low: -196.849
 PE/G Ratio -2.326
 Price To Sales (P/S)
Price To Sales QoQ
Price To Sales YoY
Price To Sales IPRWA
FORWARD MULTIPLES
Forward P/E -61.545
Forward PE/G -3.6
Forward P/S
EFFICIENCY OPERATIONAL
 Operating Leverage
ASSET & SALES
 Asset Turnover Ratio
Asset Turnover Ratio QoQ
Asset Turnover Ratio YoY
Asset Turnover Ratio IPRWA
 Receivables Turnover
Receivables Turnover Ratio QoQ
Receivables Turnover Ratio YoY
Receivables Turnover Ratio IPRWA
 Inventory Turnover
Inventory Turnover Ratio QoQ
Inventory Turnover Ratio YoY
Inventory Turnover Ratio IPRWA
 Days Sales Outstanding (DSO)
CASH CYCLE
 Cash Conversion Cycle Days (CCC) -18.322
Cash Conversion Cycle Days QoQ -15.863 %
Cash Conversion Cycle Days YoY
Cash Conversion Cycle Days IPRWA high: 937.301
mean: 206.829
median: 192.562
CRSP: -18.322
low: -1235.527
CAPITAL DEPLOYMENT
 Cash Conversion Ratio
 CapEx To Revenue
 CapEx To Depreciation -0.091
 
CAPITAL, LIQUIDITY & COVERAGE CAPITAL STRUCTURE
 Total Capital 1.9 B
 Net Invested Capital 1.9 B
 Invested Capital 1.9 B
 Net Tangible Assets 1.9 B
 Net Working Capital 1.8 B
LIQUIDITY
 Cash Ratio 13.25
 Current Ratio 13.316
Current Ratio QoQ -17.888 %
Current Ratio YoY -39.658 %
Current Ratio IPRWA high: 30.664
CRSP: 13.316
mean: 5.378
median: 2.901
low: 0.35
 Quick Ratio
Quick Ratio QoQ
Quick Ratio YoY
Quick Ratio IPRWA
COVERAGE & LEVERAGE
 Debt To EBITDA -1.387
 Cost Of Debt 7.794 %
 Interest Coverage Ratio -8.698
Interest Coverage Ratio QoQ 17.193 %
Interest Coverage Ratio YoY 139.617 %
Interest Coverage Ratio IPRWA high: 224.172
mean: 5.245
median: 3.319
CRSP: -8.698
low: -376.787
 Operating Cash Flow Ratio -0.842
TIMING / LIQUIDITY
 Days Payables Outstanding (DPO) 18.322
DIVIDENDS
 Dividend Coverage Ratio
 Dividend Payout Ratio
 Dividend Rate
 Dividend Yield
PERFORMANCE GROWTH
 Asset Growth Rate 0.888 %
 Revenue Growth 6669.826 %
Revenue Growth QoQ 16.729 %
Revenue Growth YoY 16.729 %
Revenue Growth IPRWA CRSP: 6669.826 %
high: 219.093 %
mean: 14.346 %
median: 2.844 %
low: -111.016 %
 Earnings Growth 17.094 %
Earnings Growth QoQ -283.767 %
Earnings Growth YoY -130.289 %
Earnings Growth IPRWA high: 111.538 %
CRSP: 17.094 %
mean: -25.647 %
median: -28.729 %
low: -170.677 %
MARGINS
 Gross Margin
Gross Margin QoQ
Gross Margin YoY
Gross Margin IPRWA
 EBIT Margin
EBIT Margin QoQ
EBIT Margin YoY
EBIT Margin IPRWA
 Return On Sales (ROS)
Return On Sales QoQ
Return On Sales YoY
Return On Sales IPRWA
CASH FLOW
 Free Cash Flow (FCF) -93.07 M
 Free Cash Flow Yield -1.782 %
Free Cash Flow Yield QoQ 21.472 %
Free Cash Flow Yield YoY 32.392 %
Free Cash Flow Yield IPRWA high: 14.775 %
median: 0.511 %
mean: 0.4 %
CRSP: -1.782 %
low: -21.858 %
 Free Cash Growth 9.872 %
Free Cash Growth QoQ -125.275 %
Free Cash Growth YoY -118.604 %
Free Cash Growth IPRWA high: 205.565 %
CRSP: 9.872 %
median: -24.526 %
mean: -26.748 %
low: -201.25 %
 Free Cash To Net Income 0.713
 Cash Flow Margin
 Cash Flow To Earnings 0.962
VALUE & RETURNS
 Economic Value Added 0.04
 Return On Assets (ROA) -5.791 %
Return On Assets QoQ 16.285 %
Return On Assets YoY 249.066 %
Return On Assets IPRWA high: 18.9 %
median: 1.475 %
mean: -1.603 %
CRSP: -5.791 %
low: -43.276 %
 Return On Capital Employed (ROCE) -7.314 %
 Return On Equity (ROE) -0.068
Return On Equity QoQ 22.34 %
Return On Equity YoY 251.942 %
Return On Equity IPRWA high: 0.553
median: 0.064
mean: 0.02
CRSP: -0.068
low: -0.745
 DuPont ROE
 Return On Invested Capital (ROIC) -7.369 %
Return On Invested Capital QoQ 16.838 %
Return On Invested Capital YoY -309.525 %
Return On Invested Capital IPRWA high: 19.946 %
median: 3.016 %
mean: 1.244 %
CRSP: -7.369 %
low: -38.753 %

Six-Week Outlook

Convertible debt issuance increases the firm’s cash buffer but introduces potential redeemable/dilutive mechanics that markets priced into the share. Combined with weakening momentum (MACD below signal, RSI peak‑and‑reversal) and price below key moving averages, expect range‑bound to downward price bias over the next six weeks with volatility likely above recent averages. Any technical recovery must clear the 20‑day average near $56.49 and re‑establish MACD momentum above its signal to shift the near‑term directional bias. WMDST values the stock as over‑valued, and current fundamentals—strong revenue growth offset by persistent losses—support a cautious outlook until earnings quality and cash‑flow generation materially improve.

About CRISPR Therapeutics AG

Crispr Therapeutics AG (NASDAQ:CRSP) develops transformative gene-based therapies using CRISPR/Cas9 technology. Headquartered in Zug, Switzerland, and established in 2013, the company addresses serious human diseases through precise genomic DNA modifications. Their therapeutic portfolio includes treatments for hemoglobinopathies, oncology, autoimmune disorders, and type 1 diabetes. The lead product candidate, CASGEVY, represents an ex vivo gene-edited cell therapy aimed at treating transfusion-dependent beta-thalassemia and severe sickle cell disease by promoting fetal hemoglobin production in red blood cells. Crispr Therapeutics also advances CAR T cell therapies targeting oncology and autoimmune diseases, alongside in vivo gene editing for cardiovascular conditions. Strategic collaborations with industry leaders such as Vertex Pharmaceuticals, ViaCyte, Nkarta, and Capsida Biotherapeutics enhance their innovation efforts. By focusing on precision medicine, Crispr Therapeutics AG aims to redefine genetic disease treatment, offering potential cures rather than conventional treatments.



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