Illumina, Inc (NASDAQ:ILMN) Accelerates Clinical Integration, Positioning For Continued Fundamental Revaluation

Illumina shows operational momentum from product and partnership rollouts while fundamentals exhibit mixed improvement that underpins a WMDST valuation of under-valued.

Recent News

April 7, 2026 — GRAIL announced integration of the Galleri multi-cancer early detection test into the Epic electronic health record platform to expand clinical access. April 14, 2026 — Illumina partnered with the Center for Data-Driven Discovery in Biomedicine to supply genomic data and scalable software for pediatric cancer and rare-disease research. April 21, 2026 — GRAIL confirmed plans to present new NHS-Galleri and PATHFINDER 2 data at the 2026 ASCO annual meeting.

Technical Analysis

ADX at 13.15 indicates no dominant trend; the absence of trend strength lowers conviction for directional breakouts and frames near-term moves as range-bound versus trending.

Directional indicators show DI+ at 23.90 with a peak-and-reversal (bearish) and DI- at 19.42 with a dip-and-reversal (bearish), together signaling increased downside pressure on price momentum relative to recent directional strength.

MACD reads 3.66 above its signal line at 3.44 (a bullish crossover), yet the MACD trend shows a peak-and-reversal, signaling that bullish crossover strength may fade as momentum weakens; reconcile by treating the current histogram advantage as vulnerable to deterioration.

MRO at 31.54 with a peak-and-reversal places the market price above the model target and implies potential downside pressure as valuation realigns toward intrinsic benchmarks.

RSI at 55.33 and increasing indicates mild bullish momentum without overbought conditions, supporting the possibility of limited upside within the current consolidation band rather than a strong trend extension.

Price sits at $141.92, above the 200-day average of $120.60 and marginally above the 20-day average of $141.53; the 12-day EMA at $140.71 trends higher, implying short-term support near recent averages while upper Bollinger levels leave room to the $147.34 band before volatility typically expands.

 


Fundamental Analysis

Revenue totaled $1,091,000,000 with YoY revenue growth of 2.80% and a quarter-over-quarter figure of -184.80%; the YoY gain reflects modest top-line expansion while the reported QoQ swing indicates pronounced seasonal or timing effects in the quarter reported.

Gross margin at 66.09% and operating margin at 19.16% signal high product-level profitability and operational leverage. EBIT margin equals 16.59%, above the industry peer mean of 13.635% and below the industry peer high of 23.643%; however, EBIT margin declined QoQ by -52.29% and YoY by -16.57%, reflecting near-term margin pressure versus the longer-term level.

EPS came in at $1.15 versus an estimate of $1.05, producing an EPS surprise of 9.5%, which improved reported earnings versus expectations for the period.

Cash and short-term investments reached $1,155,000,000 with operating cash flow of $250,000,000 and free cash flow of $251,000,000; free cash flow yield sits at 1.30%, above the industry peer mean of 0.382%, though free cash flow yield fell YoY by -9.60%.

Leverage shows total debt of $2,544,000,000 and net debt of $900,000,000; debt-to-EBITDA equals 10.18x and debt-to-equity equals 0.95x, with debt-to-equity above the industry peer mean of 0.71196, indicating higher leverage relative to peers and sensitivity to earnings variability.

Return metrics register return on equity at 5.01% and return on invested capital at 3.31%, both above their respective industry peer means, suggesting efficient capital returns despite growth headwinds. Earnings growth reads -14.82% overall and shows notable QoQ pressure, aligning with margin compressions cited earlier.

Valuation context: price multiples run rich in places—P/E near 110.5x and P/B at 7.22x—while enterprise-value measures (enterprise multiple ~82.81x) and a forward P/E near 86.69x reflect market expectations for future margin or growth recovery. WMDST values the stock as under-valued, a view that the current fundamental cash generation, improving product integrations, and premium multiples can reconcile over time if operational trends stabilize.

MOST-RECENT QUARTERLY REPORT
REPORT PERIOD ENDING: 2026-03-31
REPORT DATE: 2026-04-30
NEXT REPORT DATE: 2026-07-30
CASH FLOW  Begin Period Cash Flow 1.4 B
 Operating Cash Flow 250.0 M
 Capital Expenditures -38.00 M
 Change In Working Capital -1.00 M
 Dividends Paid
 Cash Flow Delta -329.00 M
 End Period Cash Flow 1.1 B
 
INCOME STATEMENT REVENUE
 Total Revenue 1.1 B
 Forward Revenue 457.2 M
COSTS
 Cost Of Revenue 370.0 M
 Depreciation 51.0 M
 Depreciation and Amortization 69.0 M
 Research and Development 240.0 M
 Total Operating Expenses 882.0 M
PROFITABILITY
 Gross Profit 721.0 M
 EBITDA 250.0 M
 EBIT 181.0 M
 Operating Income 209.0 M
 Interest Income 11.0 M
 Interest Expense 24.0 M
 Net Interest Income -13.00 M
 Income Before Tax 157.0 M
 Tax Provision 23.0 M
 Tax Rate 14.65 %
 Net Income 134.0 M
 Net Income From Continuing Operations 134.0 M
EARNINGS
 EPS Estimate 1.05
 EPS Actual 1.15
 EPS Difference 0.10
 EPS Surprise 9.524 %
 Forward EPS 1.48
 
BALANCE SHEET ASSETS
 Total Assets 6.6 B
 Intangible Assets 1.7 B
 Net Tangible Assets 962.0 M
 Total Current Assets 2.7 B
 Cash and Short-Term Investments 1.2 B
 Cash 1.1 B
 Net Receivables 738.0 M
 Inventory 611.0 M
 Long-Term Investments 523.0 M
LIABILITIES
 Accounts Payable 218.0 M
 Short-Term Debt 499.0 M
 Total Current Liabilities 1.6 B
 Net Debt 900.0 M
 Total Debt 2.5 B
 Total Liabilities 3.9 B
EQUITY
 Total Equity 2.7 B
 Retained Earnings -258.00 M
VALUATION & PER-SHARE METRICS EQUITY & PER-SHARE METRICS
 Book Value Per-Share 17.61
 Shares Outstanding 152.000 M
 Revenue Per-Share 7.18
VALUATION
 Market Capitalization 19.3 B
 Enterprise Value 20.7 B
 Enterprise Multiple 82.81
Enterprise Multiple QoQ 81.626 %
Enterprise Multiple YoY 48.899 %
Enterprise Multiple IPRWA high: 221.771
mean: 84.157
ILMN: 82.81
median: 82.306
low: -94.625
 EV/R 18.976
CAPITAL STRUCTURE
 Asset To Equity 2.451
 Asset To Liability 1.689
 Debt To Capital 0.487
 Debt To Assets 0.388
Debt To Assets QoQ 0.937 %
Debt To Assets YoY -8.027 %
Debt To Assets IPRWA high: 0.694
ILMN: 0.388
median: 0.381
mean: 0.337
low: 0.046
 Debt To Equity 0.951
Debt To Equity QoQ 1.397 %
Debt To Equity YoY -13.648 %
Debt To Equity IPRWA high: 1.28
ILMN: 0.951
median: 0.831
mean: 0.712
low: 0.053
PRICE-BASED VALUATION
 Price To Book (P/B) 7.217
Price To Book QoQ -3.962 %
Price To Book YoY 22.253 %
Price To Book IPRWA ILMN: 7.217
high: 6.871
mean: 3.857
median: 3.707
low: 0.163
 Price To Earnings (P/E) 110.489
Price To Earnings QoQ 11.524 %
Price To Earnings YoY 21.896 %
Price To Earnings IPRWA high: 338.717
ILMN: 110.489
mean: 96.057
median: 95.233
low: -211.689
 PE/G Ratio -7.458
 Price To Sales (P/S) 17.703
Price To Sales QoQ 0.263 %
Price To Sales YoY 31.822 %
Price To Sales IPRWA high: 36.903
mean: 18.549
ILMN: 17.703
median: 17.494
low: 0.107
FORWARD MULTIPLES
Forward P/E 86.693
Forward PE/G -5.852
Forward P/S 42.239
EFFICIENCY OPERATIONAL
 Operating Leverage 9.389
ASSET & SALES
 Asset Turnover Ratio 0.165
Asset Turnover Ratio QoQ -8.59 %
Asset Turnover Ratio YoY -0.893 %
Asset Turnover Ratio IPRWA high: 0.168
ILMN: 0.165
mean: 0.105
median: 0.098
low: 0.035
 Receivables Turnover 1.371
Receivables Turnover Ratio QoQ -6.4 %
Receivables Turnover Ratio YoY -5.598 %
Receivables Turnover Ratio IPRWA high: 3.506
ILMN: 1.371
mean: 1.284
median: 1.216
low: 1.147
 Inventory Turnover 0.63
Inventory Turnover Ratio QoQ -9.153 %
Inventory Turnover Ratio YoY -4.652 %
Inventory Turnover Ratio IPRWA high: 2.484
median: 1.204
mean: 1.094
ILMN: 0.63
low: 0.207
 Days Sales Outstanding (DSO) 66.577
CASH CYCLE
 Cash Conversion Cycle Days (CCC) 148.359
Cash Conversion Cycle Days QoQ -2.897 %
Cash Conversion Cycle Days YoY 4.148 %
Cash Conversion Cycle Days IPRWA high: 393.16
ILMN: 148.359
mean: 114.967
median: 100.104
low: 42.31
CAPITAL DEPLOYMENT
 Cash Conversion Ratio 0.931
 CapEx To Revenue -0.035
 CapEx To Depreciation -0.745
 
CAPITAL, LIQUIDITY & COVERAGE CAPITAL STRUCTURE
 Total Capital 4.2 B
 Net Invested Capital 4.7 B
 Invested Capital 4.7 B
 Net Tangible Assets 962.0 M
 Net Working Capital 1.2 B
LIQUIDITY
 Cash Ratio 0.738
 Current Ratio 1.748
Current Ratio QoQ -15.743 %
Current Ratio YoY -5.81 %
Current Ratio IPRWA high: 12.356
mean: 2.089
ILMN: 1.748
median: 1.526
low: 0.267
 Quick Ratio 1.358
Quick Ratio QoQ -20.998 %
Quick Ratio YoY -8.433 %
Quick Ratio IPRWA high: 11.915
mean: 1.609
ILMN: 1.358
median: 1.15
low: 0.211
COVERAGE & LEVERAGE
 Debt To EBITDA 10.176
 Cost Of Debt 0.898 %
 Interest Coverage Ratio 7.542
Interest Coverage Ratio QoQ -51.344 %
Interest Coverage Ratio YoY -8.917 %
Interest Coverage Ratio IPRWA high: 30.652
ILMN: 7.542
median: 5.898
mean: 2.924
low: -270.336
 Operating Cash Flow Ratio 0.16
TIMING / LIQUIDITY
 Days Payables Outstanding (DPO) 52.241
DIVIDENDS
 Dividend Coverage Ratio
 Dividend Payout Ratio
 Dividend Rate
 Dividend Yield
PERFORMANCE GROWTH
 Asset Growth Rate -1.279 %
 Revenue Growth -5.867 %
Revenue Growth QoQ -184.795 %
Revenue Growth YoY 2.804 %
Revenue Growth IPRWA high: 32.205 %
ILMN: -5.867 %
mean: -7.832 %
median: -9.906 %
low: -16.725 %
 Earnings Growth -14.815 %
Earnings Growth QoQ -2085.925 %
Earnings Growth YoY -215.824 %
Earnings Growth IPRWA high: 108.696 %
mean: -12.136 %
ILMN: -14.815 %
median: -17.199 %
low: -140.0 %
MARGINS
 Gross Margin 66.086 %
Gross Margin QoQ 0.915 %
Gross Margin YoY 0.725 %
Gross Margin IPRWA high: 83.743 %
ILMN: 66.086 %
mean: 44.336 %
median: 40.254 %
low: 4.636 %
 EBIT Margin 16.59 %
EBIT Margin QoQ -52.288 %
EBIT Margin YoY -16.57 %
EBIT Margin IPRWA high: 23.643 %
median: 18.973 %
ILMN: 16.59 %
mean: 13.635 %
low: -170.307 %
 Return On Sales (ROS) 19.157 %
Return On Sales QoQ 5.229 %
Return On Sales YoY -3.661 %
Return On Sales IPRWA high: 24.243 %
ILMN: 19.157 %
median: 17.383 %
mean: 15.98 %
low: -173.107 %
CASH FLOW
 Free Cash Flow (FCF) 251.0 M
 Free Cash Flow Yield 1.3 %
Free Cash Flow Yield QoQ 0.0 %
Free Cash Flow Yield YoY -9.597 %
Free Cash Flow Yield IPRWA ILMN: 1.3 %
high: 1.021 %
median: 0.424 %
mean: 0.382 %
low: -25.298 %
 Free Cash Growth -5.639 %
Free Cash Growth QoQ -344.324 %
Free Cash Growth YoY -85.903 %
Free Cash Growth IPRWA high: 341.975 %
ILMN: -5.639 %
mean: -64.418 %
median: -72.727 %
low: -125.322 %
 Free Cash To Net Income 1.873
 Cash Flow Margin 22.915 %
 Cash Flow To Earnings 1.866
VALUE & RETURNS
 Economic Value Added 0.04
 Return On Assets (ROA) 2.03 %
Return On Assets QoQ -61.036 %
Return On Assets YoY -3.287 %
Return On Assets IPRWA high: 2.388 %
ILMN: 2.03 %
median: 1.477 %
mean: 1.2 %
low: -7.968 %
 Return On Capital Employed (ROCE) 3.625 %
 Return On Equity (ROE) 0.05
Return On Equity QoQ -59.18 %
Return On Equity YoY -9.49 %
Return On Equity IPRWA high: 0.226
ILMN: 0.05
median: 0.032
mean: 0.026
low: -0.421
 DuPont ROE 4.964 %
 Return On Invested Capital (ROIC) 3.312 %
Return On Invested Capital QoQ -56.289 %
Return On Invested Capital YoY -3.13 %
Return On Invested Capital IPRWA ILMN: 3.312 %
high: 3.177 %
median: 2.107 %
mean: 1.763 %
low: -6.427 %

Six-Week Outlook

Near-term action should favor range-based setups: technicals show no strong trend and momentum indicators signal vulnerability to pullbacks even as short-term EMAs trend higher. Ongoing clinical integrations and data presentations may produce event-driven intraday/weekly volatility; monitor liquidity and volume patterns as catalysts for directional conviction. The risk profile stems from elevated leverage and compressed quarterly margins, while the balance of fundamental cash flow and product momentum supports episodic recoveries rather than a sustained breakout barring new fundamental developments.

About Illumina, Inc.

Illumina, Inc. (NASDAQ:ILMN) develops and supplies advanced genetic and genomic analysis tools. Based in San Diego, California, the company offers a wide range of sequencing and array-based solutions that address various genomic needs. Illumina’s portfolio includes high-performance sequencing instruments, essential reagents, and consumables, as well as comprehensive whole-genome and targeted resequencing kits. The company’s technological advancements support critical healthcare applications, including noninvasive prenatal testing and cancer diagnostics, such as the Galleri multi-cancer early detection test. Illumina’s innovations facilitate the detection of minimal residual disease through blood-based diagnostics, contributing to improved post-diagnostic care. Illumina serves a diverse clientele, including genomic research centers, academic institutions, and companies in the pharmaceutical and biotechnology sectors. By distributing its products directly and through life-science distributors, Illumina aims to advance scientific discovery and enhance human health globally. Through its Core Illumina and GRAIL segments, the company continues to lead in the development of technologies that drive progress in genomics.



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