Scholar Rock Holding Corporation (NASDAQ:SRRK) Advances Toward Potential Approval; Near-Term Volatility Likely

Pipeline progress around apitegromab and recent regulatory alignment brighten the clinical outlook while technical indicators show mixed momentum, implying short-term swings against a stretched valuation.

Recent News

On March 31, 2026 Scholar Rock announced it resubmitted the Biologics License Application for apitegromab for children and adults with spinal muscular atrophy, incorporating Catalent Indiana and a second U.S. fill‑finish facility to align with FDA guidance. Secondary reports confirm the resubmission returns apitegromab to active review and note parallel regulatory activity in the European review process.

Technical Analysis

ADX stands at 19.69, below 20, indicating no established trend; price momentum depends on directional signals rather than a dominant trend.

Directional indicators show bullish bias: DI+ at 22.04 with a dip & reversal signals renewed upside pressure, while DI- at 12.98 decreasing reinforces that bias.

MACD sits at 0.60 and has undergone a dip & reversal; MACD currently trades above its 0.32 signal line, a bullish momentum confirmation that supports short-term upward attempts.

MRO reads 28.21 with a peak & reversal, indicating price sits above the implied target and faces downside pressure from mean‑reversion risk despite other bullish signals.

RSI at 55.22 with a dip & reversal shows momentum returned from a minor pullback but remains mid‑range, not at overbought extremes.

Price sits above key averages: close $51.28 exceeds the 20‑day average $47.63, 50‑day average $46.53 and 200‑day average $40.54, signaling multi‑horizon strength. The 12‑day EMA (price12dayEMA $48.53) shows a dip & reversal consistent with recent recovery attempts.

Bollinger positioning appears stretched: the price slightly exceeds the upper 2× standard deviation band ($51.23), suggesting the recent rally reached an extreme band and raises the chance of a near‑term pullback or consolidation.

Volume runs at 2,189,464, above the 10‑day average 1,327,126 and the 50‑day average 1,546,211, indicating heightened trading interest that can amplify intramarket moves.

 


Fundamental Analysis

Operational profitability remains negative: EBIT -$88.4M, EBITDA -$88.0M and net loss -$90.97M reflect ongoing development spending typical for late‑stage biotech.

Liquidity and capital structure: cash $323.5M and cash and short‑term investments $367.6M provide material liquidity against total debt $108.9M. Cash and short‑term investments represent roughly 4.2 times the reported operating cash outflow figure, while the cash ratio of 6.63 and current ratio of 6.95 indicate strong short‑term coverage. The current ratio sits above the industry peer mean of 3.74 and above the industry peer median of 2.83.

Balance sheet leverage shows debt to assets 26.94% and debt to equity 44.37%; both measures exceed the industry peer mean values for those metrics, indicating moderately higher leverage relative to peers.

R&D and expense composition: research and development $46.9M represents about 51.0% of total operating expenses $91.9M, underscoring the company’s development focus supporting apitegromab and SRK‑181 programs.

Earnings and market multiples: reported EPS -$0.83 versus estimate -$0.80 produced an EPS surprise of -3.75%. Price/book at 19.43 exceeds the industry peer mean of 5.15 and marginally surpasses the industry peer high of 19.17, signaling a valuation premium versus peers. Forward PE remains negative at -72.29 due to projected losses; PEG sits at 22.49 while forward PEG sits at 32.54, both reflecting market expectations priced into growth forecasts despite negative earnings.

Cash generation and returns: free cash flow -$75.5M and free cash flow yield -1.58% indicate ongoing cash burn. Return on equity -37.06% and return on assets -22.30% reflect negative profitability during the development phase.

Analyst price targets embedded in market data show a mean target $63.82, about 24.5% above the current close $51.28, while the internal valuation assigned here shows the current valuation as over‑valued by WMDST given elevated multiples and negative profitability.

MOST-RECENT QUARTERLY REPORT
REPORT PERIOD ENDING: 2025-12-31
REPORT DATE: 2026-05-07
NEXT REPORT DATE: 2026-08-06
CASH FLOW  Begin Period Cash Flow 290.6 M
 Operating Cash Flow -87.00 M
 Capital Expenditures -32.00 K
 Change In Working Capital -5.66 M
 Dividends Paid
 Cash Flow Delta 36.8 M
 End Period Cash Flow 327.3 M
 
INCOME STATEMENT REVENUE
 Total Revenue
 Forward Revenue
COSTS
 Cost Of Revenue
 Depreciation 425.0 K
 Depreciation and Amortization 425.0 K
 Research and Development 46.9 M
 Total Operating Expenses 91.9 M
PROFITABILITY
 Gross Profit
 EBITDA -88.01 M
 EBIT -88.43 M
 Operating Income -91.90 M
 Interest Income 3.5 M
 Interest Expense 2.5 M
 Net Interest Income 992.0 K
 Income Before Tax -90.97 M
 Tax Provision
 Tax Rate
 Net Income -90.97 M
 Net Income From Continuing Operations -90.97 M
EARNINGS
 EPS Estimate -0.80
 EPS Actual -0.83
 EPS Difference -0.03
 EPS Surprise -3.75 %
 Forward EPS -0.57
 
BALANCE SHEET ASSETS
 Total Assets 404.3 M
 Intangible Assets
 Net Tangible Assets 245.5 M
 Total Current Assets 385.1 M
 Cash and Short-Term Investments 367.6 M
 Cash 323.5 M
 Net Receivables
 Inventory
 Long-Term Investments 3.8 M
LIABILITIES
 Accounts Payable 10.3 M
 Short-Term Debt
 Total Current Liabilities 55.4 M
 Net Debt
 Total Debt 108.9 M
 Total Liabilities 158.8 M
EQUITY
 Total Equity 245.5 M
 Retained Earnings -1.30 B
VALUATION & PER-SHARE METRICS EQUITY & PER-SHARE METRICS
 Book Value Per-Share 2.26
 Shares Outstanding 108.461 M
 Revenue Per-Share
VALUATION
 Market Capitalization 4.8 B
 Enterprise Value 4.5 B
 Enterprise Multiple -51.265
Enterprise Multiple QoQ 76.087 %
Enterprise Multiple YoY 10.907 %
Enterprise Multiple IPRWA high: 67.346
median: 46.684
mean: 12.664
SRRK: -51.265
low: -114.076
 EV/R
CAPITAL STRUCTURE
 Asset To Equity 1.647
 Asset To Liability 2.546
 Debt To Capital 0.307
 Debt To Assets 0.269
Debt To Assets QoQ 0.767 %
Debt To Assets YoY 96.463 %
Debt To Assets IPRWA high: 1.032
SRRK: 0.269
mean: 0.118
median: 0.005
low: 0.0
 Debt To Equity 0.444
Debt To Equity QoQ -1.253 %
Debt To Equity YoY 151.129 %
Debt To Equity IPRWA high: 1.524
SRRK: 0.444
mean: 0.142
median: 0.005
low: -0.893
PRICE-BASED VALUATION
 Price To Book (P/B) 19.432
Price To Book QoQ 49.501 %
Price To Book YoY 101.225 %
Price To Book IPRWA SRRK: 19.432
high: 19.174
median: 6.164
mean: 5.153
low: -10.511
 Price To Earnings (P/E) -49.979
Price To Earnings QoQ 40.084 %
Price To Earnings YoY -19.647 %
Price To Earnings IPRWA high: 71.892
mean: -21.207
median: -32.121
SRRK: -49.979
low: -107.019
 PE/G Ratio 22.493
 Price To Sales (P/S)
Price To Sales QoQ
Price To Sales YoY
Price To Sales IPRWA
FORWARD MULTIPLES
Forward P/E -72.294
Forward PE/G 32.536
Forward P/S
EFFICIENCY OPERATIONAL
 Operating Leverage
ASSET & SALES
 Asset Turnover Ratio
Asset Turnover Ratio QoQ
Asset Turnover Ratio YoY
Asset Turnover Ratio IPRWA
 Receivables Turnover
Receivables Turnover Ratio QoQ
Receivables Turnover Ratio YoY
Receivables Turnover Ratio IPRWA
 Inventory Turnover
Inventory Turnover Ratio QoQ
Inventory Turnover Ratio YoY
Inventory Turnover Ratio IPRWA
 Days Sales Outstanding (DSO)
CASH CYCLE
 Cash Conversion Cycle Days (CCC)
Cash Conversion Cycle Days QoQ
Cash Conversion Cycle Days YoY
Cash Conversion Cycle Days IPRWA high: 937.301
mean: 220.236
median: 192.562
SRRK: 0
low: -594.03
CAPITAL DEPLOYMENT
 Cash Conversion Ratio
 CapEx To Revenue
 CapEx To Depreciation -0.075
 
CAPITAL, LIQUIDITY & COVERAGE CAPITAL STRUCTURE
 Total Capital 345.2 M
 Net Invested Capital 345.2 M
 Invested Capital 345.2 M
 Net Tangible Assets 245.5 M
 Net Working Capital 329.7 M
LIQUIDITY
 Cash Ratio 6.632
 Current Ratio 6.95
Current Ratio QoQ 10.232 %
Current Ratio YoY -27.7 %
Current Ratio IPRWA high: 27.397
SRRK: 6.95
mean: 3.738
median: 2.827
low: 0.027
 Quick Ratio
Quick Ratio QoQ
Quick Ratio YoY
Quick Ratio IPRWA
COVERAGE & LEVERAGE
 Debt To EBITDA -1.238
 Cost Of Debt 2.314 %
 Interest Coverage Ratio -34.898
Interest Coverage Ratio QoQ -53.855 %
Interest Coverage Ratio YoY -43.143 %
Interest Coverage Ratio IPRWA high: 671.002
mean: 40.568
median: 3.11
SRRK: -34.898
low: -1571.333
 Operating Cash Flow Ratio -1.57
TIMING / LIQUIDITY
 Days Payables Outstanding (DPO)
DIVIDENDS
 Dividend Coverage Ratio
 Dividend Payout Ratio
 Dividend Rate
 Dividend Yield
PERFORMANCE GROWTH
 Asset Growth Rate -1.809 %
 Revenue Growth
Revenue Growth QoQ
Revenue Growth YoY
Revenue Growth IPRWA
 Earnings Growth -2.222 %
Earnings Growth QoQ -72.78 %
Earnings Growth YoY -70.671 %
Earnings Growth IPRWA high: 204.0 %
SRRK: -2.222 %
median: -14.444 %
mean: -16.996 %
low: -247.059 %
MARGINS
 Gross Margin
Gross Margin QoQ
Gross Margin YoY
Gross Margin IPRWA
 EBIT Margin
EBIT Margin QoQ
EBIT Margin YoY
EBIT Margin IPRWA
 Return On Sales (ROS)
Return On Sales QoQ
Return On Sales YoY
Return On Sales IPRWA
CASH FLOW
 Free Cash Flow (FCF) -75.53 M
 Free Cash Flow Yield -1.583 %
Free Cash Flow Yield QoQ -26.95 %
Free Cash Flow Yield YoY 13.721 %
Free Cash Flow Yield IPRWA high: 21.452 %
median: 0.303 %
mean: 0.183 %
SRRK: -1.583 %
low: -51.848 %
 Free Cash Growth 9.45 %
Free Cash Growth QoQ -189.472 %
Free Cash Growth YoY -268.09 %
Free Cash Growth IPRWA high: 177.21 %
SRRK: 9.45 %
median: -24.526 %
mean: -32.998 %
low: -201.25 %
 Free Cash To Net Income 0.83
 Cash Flow Margin
 Cash Flow To Earnings 0.956
VALUE & RETURNS
 Economic Value Added
 Return On Assets (ROA) -22.296 %
Return On Assets QoQ -18.014 %
Return On Assets YoY 9.719 %
Return On Assets IPRWA high: 33.814 %
median: 1.099 %
mean: -2.633 %
SRRK: -22.296 %
low: -65.985 %
 Return On Capital Employed (ROCE) -25.349 %
 Return On Equity (ROE) -0.371
Return On Equity QoQ -11.188 %
Return On Equity YoY 105.553 %
Return On Equity IPRWA high: 0.809
median: 0.036
mean: 0.002
SRRK: -0.371
low: -1.16
 DuPont ROE
 Return On Invested Capital (ROIC)
Return On Invested Capital QoQ
Return On Invested Capital YoY
Return On Invested Capital IPRWA

Six-Week Outlook

Expect elevated volatility driven by regulatory milestones and supply‑chain commentary around fill‑finish readiness. Short‑term technicals skew bullish: DI+ reversal, MACD above its signal, and price trading above short and medium moving averages support additional upside testing. Countervailing signals include ADX below 20 (no dominant trend), an MRO peak & reversal signaling mean‑reversion risk, and price sitting slightly above the upper Bollinger band—factors that raise the probability of swift pullbacks or sideways consolidation.

Liquidity and fundamentals allow the company to operate through near‑term catalyst windows, yet negative earnings and free cash flow keep valuation elevated relative to replaceable fundamentals. Monitor regulatory notices about apitegromab supply and agency interactions for triggers; absent fresh regulatory confirmation, technical exhaustion could prompt corrective moves before any sustained advance.

About Scholar Rock Holding Corporation

Scholar Rock Holding Corporation (NASDAQ:SRRK) develops innovative biopharmaceutical solutions targeting serious diseases influenced by protein growth factor signaling. The company advances Apitegromab, a myostatin activation inhibitor, currently undergoing Phase 3 clinical trials aimed at treating spinal muscular atrophy. Scholar Rock also progresses SRK-181, which has completed Phase 1 trials, targeting cancers resistant to checkpoint inhibitor therapies, including anti-PD-1 and anti-PD-L1 antibody therapies. Their pipeline includes potential treatments for neuromuscular disorders, cardiometabolic disorders, cancer, fibrosis, and iron-restricted anemia. Founded in 2012, Scholar Rock operates from its headquarters in Cambridge, Massachusetts, driving forward the development of novel therapeutic candidates to address unmet medical needs.



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