Illumina, Inc (NASDAQ:ILMN) Extends Profit Recovery While Clinical Demand Accelerates

Illumina shows momentum through improving instrument placements and margin expansion, supported by cash generation and a fresh $1.5 billion repurchase authorization. Near-term technicals suggest continued upside tempered by an above-target price signal.

Recent News

On April 2, 2026 the company announced planned retirements of three directors and nominated a new director for election at the annual meeting. On April 28, 2026 the board authorized a new share repurchase program of up to $1.5 billion. Grail, the company’s former unit with ongoing commercial products, announced NHS Galleri trial results on February 19, 2026 showing improved stage-shift detection for multiple cancers. Separately, Grail has pursued damages and costs against the European Commission related to the earlier regulatory veto of Illumina’s acquisition, a development reported in April 2026.

Technical Analysis

ADX at 13.13 indicates no dominant trend; directional indicators present a short-lived directional tug. DI+ registered a peak-and-reversal, which reads as bearish pressure following a prior advance, while DI- decreasing signals reduced selling intensity—together these suggest market indecision rather than sustained directional conviction.

MACD sits at 3.06 with the MACD line above the signal line (1.83) and an increasing MACD trend; that cross-above constitutes a bullish momentum signal and supports the case for further near-term upside continuation from current levels.

MRO at 32.34 and rising identifies the price as above the internal target and denotes elevated downside potential toward fair-value anchors; this amplifies the risk of a corrective pullback even as momentum indicators remain constructive.

RSI at 54.04 and climbing shows mild bullish momentum without extended overbought stress, aligning with price holding above several moving averages and recent intraday highs.

Price sits above the 20-, 50- and 200-day averages (20d: $132.55; 50d: $127.67; 200d: $119.07) and the 12-day EMA is rising, which supports a near-term price bias higher. The close of $141.88 trades near the upper 1x Bollinger band ($140.36), implying strength but also vulnerability to volatility-driven mean reversion. Short-term volume ran slightly below the 10- and 50-day averages, suggesting recent advances proceeded without a sustained pickup in trading participation.

 


Fundamental Analysis

Revenue for the period totaled $1.091 billion and YoY revenue growth registered 2.80%. Operating cash flow stood at $250 million with free cash flow of $251 million; free-cash-flow yield equals 1.30%. EPS came in at $1.15 versus an estimate of $1.05, producing an EPS surprise of 9.52%. These results underline improving profitability and cash conversion.

Profitability metrics show operating margin at 19.16% and EBIT margin at 16.59%. EBIT margin sits above the industry peer mean and below the industry peer median, while quarter-over-quarter EBIT margin contracted by about 52.3% and year-over-year declined roughly 16.6%, indicating margin volatility tied to period-specific items and mix shifts.

Balance-sheet and leverage metrics present mixed signals: cash and short-term investments total $1.155 billion and net debt equals $900 million; debt to EBITDA measures 10.18x while interest coverage near 7.54x. High debt-to-EBITDA reflects leverage relative to current earnings, but adequate interest coverage and positive operating cash flow mitigate solvency concerns in the near term.

Operational efficiency shows asset turnover at 0.165 and a cash-conversion cycle of ~148 days, above the industry peer mean for cash-conversion days; working-capital dynamics remain stretched but produced only a modest change in working capital this period. Return on equity near 5.01% and return on assets near 2.03% reflect recovery from prior compression but still modest returns on capital.

Multiples remain elevated on reported metrics: trailing PE ~110.5 and forward PE ~86.7, with enterprise value to revenue and enterprise multiple elevated as well; WMDST values the stock as under-valued, indicating WMDST’s fair-value analysis diverges from headline multiples and rests on growth normalization and demonstrated margin improvements. Use the company’s strong cash flow and repurchase authorization as contextual inputs to the valuation stance.

MOST-RECENT QUARTERLY REPORT
REPORT PERIOD ENDING: 2026-03-31
REPORT DATE: 2026-04-30
NEXT REPORT DATE: 2026-07-30
CASH FLOW  Begin Period Cash Flow 1.4 B
 Operating Cash Flow 250.0 M
 Capital Expenditures -38.00 M
 Change In Working Capital -1.00 M
 Dividends Paid
 Cash Flow Delta -329.00 M
 End Period Cash Flow 1.1 B
 
INCOME STATEMENT REVENUE
 Total Revenue 1.1 B
 Forward Revenue 457.2 M
COSTS
 Cost Of Revenue 370.0 M
 Depreciation 51.0 M
 Depreciation and Amortization 69.0 M
 Research and Development 240.0 M
 Total Operating Expenses 882.0 M
PROFITABILITY
 Gross Profit 721.0 M
 EBITDA 250.0 M
 EBIT 181.0 M
 Operating Income 209.0 M
 Interest Income 11.0 M
 Interest Expense 24.0 M
 Net Interest Income -13.00 M
 Income Before Tax 157.0 M
 Tax Provision 23.0 M
 Tax Rate 14.65 %
 Net Income 134.0 M
 Net Income From Continuing Operations 134.0 M
EARNINGS
 EPS Estimate 1.05
 EPS Actual 1.15
 EPS Difference 0.10
 EPS Surprise 9.524 %
 Forward EPS 1.48
 
BALANCE SHEET ASSETS
 Total Assets 6.6 B
 Intangible Assets 1.7 B
 Net Tangible Assets 962.0 M
 Total Current Assets 2.7 B
 Cash and Short-Term Investments 1.2 B
 Cash 1.1 B
 Net Receivables 738.0 M
 Inventory 611.0 M
 Long-Term Investments 523.0 M
LIABILITIES
 Accounts Payable 218.0 M
 Short-Term Debt 499.0 M
 Total Current Liabilities 1.6 B
 Net Debt 900.0 M
 Total Debt 2.5 B
 Total Liabilities 3.9 B
EQUITY
 Total Equity 2.7 B
 Retained Earnings -258.00 M
VALUATION & PER-SHARE METRICS EQUITY & PER-SHARE METRICS
 Book Value Per-Share 17.61
 Shares Outstanding 152.000 M
 Revenue Per-Share 7.18
VALUATION
 Market Capitalization 19.3 B
 Enterprise Value 20.7 B
 Enterprise Multiple 82.81
Enterprise Multiple QoQ 81.626 %
Enterprise Multiple YoY 48.899 %
Enterprise Multiple IPRWA ILMN: 82.81
high: 82.306
median: 82.306
mean: 75.884
low: -94.625
 EV/R 18.976
CAPITAL STRUCTURE
 Asset To Equity 2.451
 Asset To Liability 1.689
 Debt To Capital 0.487
 Debt To Assets 0.388
Debt To Assets QoQ 0.937 %
Debt To Assets YoY -8.027 %
Debt To Assets IPRWA ILMN: 0.388
high: 0.381
median: 0.381
mean: 0.368
low: 0.141
 Debt To Equity 0.951
Debt To Equity QoQ 1.397 %
Debt To Equity YoY -13.648 %
Debt To Equity IPRWA ILMN: 0.951
high: 0.831
median: 0.831
mean: 0.797
low: 0.2
PRICE-BASED VALUATION
 Price To Book (P/B) 7.217
Price To Book QoQ -3.962 %
Price To Book YoY 22.253 %
Price To Book IPRWA ILMN: 7.217
high: 6.871
median: 3.707
mean: 3.656
low: 1.116
 Price To Earnings (P/E) 110.489
Price To Earnings QoQ 11.524 %
Price To Earnings YoY 21.896 %
Price To Earnings IPRWA high: 264.798
ILMN: 110.489
median: 95.233
mean: 94.57
low: -70.858
 PE/G Ratio -7.458
 Price To Sales (P/S) 17.703
Price To Sales QoQ 0.263 %
Price To Sales YoY 31.822 %
Price To Sales IPRWA high: 28.243
ILMN: 17.703
median: 17.494
mean: 17.488
low: 12.917
FORWARD MULTIPLES
Forward P/E 86.693
Forward PE/G -5.852
Forward P/S 42.239
EFFICIENCY OPERATIONAL
 Operating Leverage 9.389
ASSET & SALES
 Asset Turnover Ratio 0.165
Asset Turnover Ratio QoQ -8.59 %
Asset Turnover Ratio YoY -0.893 %
Asset Turnover Ratio IPRWA high: 0.168
ILMN: 0.165
median: 0.098
mean: 0.098
low: 0.058
 Receivables Turnover 1.371
Receivables Turnover Ratio QoQ -6.4 %
Receivables Turnover Ratio YoY -5.598 %
Receivables Turnover Ratio IPRWA high: 1.939
ILMN: 1.371
mean: 1.231
low: 1.216
median: 1.216
 Inventory Turnover 0.63
Inventory Turnover Ratio QoQ -9.153 %
Inventory Turnover Ratio YoY -4.652 %
Inventory Turnover Ratio IPRWA high: 1.613
median: 1.204
mean: 1.179
ILMN: 0.63
low: 0.374
 Days Sales Outstanding (DSO) 66.577
CASH CYCLE
 Cash Conversion Cycle Days (CCC) 148.359
Cash Conversion Cycle Days QoQ -2.897 %
Cash Conversion Cycle Days YoY 4.148 %
Cash Conversion Cycle Days IPRWA high: 232.098
ILMN: 148.359
mean: 104.809
median: 100.104
low: 83.093
CAPITAL DEPLOYMENT
 Cash Conversion Ratio 0.931
 CapEx To Revenue -0.035
 CapEx To Depreciation -0.745
 
CAPITAL, LIQUIDITY & COVERAGE CAPITAL STRUCTURE
 Total Capital 4.2 B
 Net Invested Capital 4.7 B
 Invested Capital 4.7 B
 Net Tangible Assets 962.0 M
 Net Working Capital 1.2 B
LIQUIDITY
 Cash Ratio 0.738
 Current Ratio 1.748
Current Ratio QoQ -15.743 %
Current Ratio YoY -5.81 %
Current Ratio IPRWA high: 11.846
ILMN: 1.748
mean: 1.625
low: 1.526
median: 1.526
 Quick Ratio 1.358
Quick Ratio QoQ -20.998 %
Quick Ratio YoY -8.433 %
Quick Ratio IPRWA high: 2.417
ILMN: 1.358
mean: 1.216
low: 1.15
median: 1.15
COVERAGE & LEVERAGE
 Debt To EBITDA 10.176
 Cost Of Debt 0.898 %
 Interest Coverage Ratio 7.542
Interest Coverage Ratio QoQ -51.344 %
Interest Coverage Ratio YoY -8.917 %
Interest Coverage Ratio IPRWA ILMN: 7.542
high: 5.898
median: 5.898
mean: -0.652
low: -270.336
 Operating Cash Flow Ratio 0.16
TIMING / LIQUIDITY
 Days Payables Outstanding (DPO) 52.241
DIVIDENDS
 Dividend Coverage Ratio
 Dividend Payout Ratio
 Dividend Rate
 Dividend Yield
PERFORMANCE GROWTH
 Asset Growth Rate -1.279 %
 Revenue Growth -5.867 %
Revenue Growth QoQ -184.795 %
Revenue Growth YoY 2.804 %
Revenue Growth IPRWA high: 6.767 %
ILMN: -5.867 %
mean: -9.826 %
median: -9.906 %
low: -14.585 %
 Earnings Growth -14.815 %
Earnings Growth QoQ -2085.925 %
Earnings Growth YoY -215.824 %
Earnings Growth IPRWA high: 108.696 %
ILMN: -14.815 %
mean: -16.527 %
median: -17.199 %
low: -24.701 %
MARGINS
 Gross Margin 66.086 %
Gross Margin QoQ 0.915 %
Gross Margin YoY 0.725 %
Gross Margin IPRWA ILMN: 66.086 %
high: 52.255 %
mean: 40.88 %
low: 40.254 %
median: 40.254 %
 EBIT Margin 16.59 %
EBIT Margin QoQ -52.288 %
EBIT Margin YoY -16.57 %
EBIT Margin IPRWA high: 18.973 %
median: 18.973 %
ILMN: 16.59 %
mean: 13.126 %
low: -114.423 %
 Return On Sales (ROS) 19.157 %
Return On Sales QoQ 5.229 %
Return On Sales YoY -3.661 %
Return On Sales IPRWA ILMN: 19.157 %
high: 17.383 %
median: 17.383 %
mean: 16.141 %
low: -34.917 %
CASH FLOW
 Free Cash Flow (FCF) 251.0 M
 Free Cash Flow Yield 1.3 %
Free Cash Flow Yield QoQ 0.0 %
Free Cash Flow Yield YoY -9.597 %
Free Cash Flow Yield IPRWA ILMN: 1.3 %
high: 1.021 %
median: 0.424 %
mean: 0.42 %
low: -3.91 %
 Free Cash Growth -5.639 %
Free Cash Growth QoQ -344.324 %
Free Cash Growth YoY -85.903 %
Free Cash Growth IPRWA high: 7.853 %
ILMN: -5.639 %
mean: -70.442 %
low: -72.727 %
median: -72.727 %
 Free Cash To Net Income 1.873
 Cash Flow Margin 22.915 %
 Cash Flow To Earnings 1.866
VALUE & RETURNS
 Economic Value Added 0.04
 Return On Assets (ROA) 2.03 %
Return On Assets QoQ -61.036 %
Return On Assets YoY -3.287 %
Return On Assets IPRWA ILMN: 2.03 %
high: 1.477 %
median: 1.477 %
mean: 1.085 %
low: -7.968 %
 Return On Capital Employed (ROCE) 3.625 %
 Return On Equity (ROE) 0.05
Return On Equity QoQ -59.18 %
Return On Equity YoY -9.49 %
Return On Equity IPRWA ILMN: 0.05
high: 0.032
median: 0.032
mean: 0.026
low: -0.102
 DuPont ROE 4.964 %
 Return On Invested Capital (ROIC) 3.312 %
Return On Invested Capital QoQ -56.289 %
Return On Invested Capital YoY -3.13 %
Return On Invested Capital IPRWA ILMN: 3.312 %
high: 2.107 %
median: 2.107 %
mean: 1.675 %
low: -6.427 %

Six-Week Outlook

Technical momentum (MACD above signal, rising EMA series, RSI ~54) supports a continuation of the recent advance, but ADX below 20 argues the move lacks trend strength; MRO’s positive reading warns the price currently sits above intrinsic target levels and thus carries correction risk. Expect price action to remain range-bound to slightly higher while the market digests corporate catalysts—board changes, the $1.5 billion repurchase program, and any developments tied to Grail litigation or clinical rollouts can trigger directional moves. Traders should monitor momentum crossovers and MRO shifts for signs of renewed buying pressure or corrective reversion; volume confirmation will matter for validating breakouts versus short-term bounces.

About Illumina, Inc.

Illumina, Inc. (NASDAQ:ILMN) develops and supplies advanced genetic and genomic analysis tools. Based in San Diego, California, the company offers a wide range of sequencing and array-based solutions that address various genomic needs. Illumina’s portfolio includes high-performance sequencing instruments, essential reagents, and consumables, as well as comprehensive whole-genome and targeted resequencing kits. The company’s technological advancements support critical healthcare applications, including noninvasive prenatal testing and cancer diagnostics, such as the Galleri multi-cancer early detection test. Illumina’s innovations facilitate the detection of minimal residual disease through blood-based diagnostics, contributing to improved post-diagnostic care. Illumina serves a diverse clientele, including genomic research centers, academic institutions, and companies in the pharmaceutical and biotechnology sectors. By distributing its products directly and through life-science distributors, Illumina aims to advance scientific discovery and enhance human health globally. Through its Core Illumina and GRAIL segments, the company continues to lead in the development of technologies that drive progress in genomics.



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