IDEAYA Biosciences, Inc (NASDAQ:IDYA) Accelerates Registrational Push With 2026 Data Catalysts

IDEAYA enters a catalyst-rich window as clinical program sequencing and strong cash metrics support near-term development execution. Operational profitability metrics contrast with short-term technical pressure, producing a clear fundamental/technical duality.

Recent News

Jan 11, 2026 — IDEAYA presented corporate objectives at the J.P. Morgan Healthcare Conference, announcing Q1 2026 topline progression-free survival (PFS) data expectations from the Phase 2/3 OptimUM‑02 darovasertib + crizotinib trial and multiple planned IND starts and registrational milestones for 2026.

Nov 28, 2025 — The company granted inducement stock options to a newly hired employee under its 2023 inducement plan, with an exercise price set at the closing market price on the grant date.

Technical Analysis

Directional indicators (ADX/DI+/DI-): ADX at 18.34 signals no established trend. DI+ at 17.73 shows a decreasing path, indicating short-term bearish pressure; DI- at 26.16 registered a peak-and-reversal, which carries a bullish implication that negative directional pressure has begun to abate.

MACD: MACD sits at -0.62 and the MACD line trades below the signal line (-0.34) while trending lower, a bearish momentum profile that suggests continuation of recent downside momentum absent an abrupt MACD crossover above the signal line.

MRO (Momentum/Regression Oscillator): MRO at -7.04 indicates the current price rests below the model target and therefore carries potential for upward mean reversion; the MRO trend shows a dip-and-reversal, supporting the potential for a move toward target levels over intermediate timeframes.

RSI: RSI at 50.4 with a decreasing trend points to neutral momentum that has softened; readings near 50 imply neither overbought nor oversold conditions but weakening short-term internals.

Price vs averages and bands: Last close $31.90 sits below the 20-day average ($33.28), the 12-day EMA ($33.14), the 26-day EMA ($33.87) and the 50-day average ($34.60), signaling short-term pressure; price remains above the 200-day average ($27.25), preserving the longer-term uptrend anchor. Bollinger bands place the 1x lower band at $32.08 and 2x lower at $30.87, with current price between those bands, suggesting compression near short-term support levels.

Ichimoku and volatility: Tenkan‑Sen ($33.67) and Kijun‑Sen ($35.20) both exceed the current price, implying short-term resistance; Senkou A ($34.67) above Senkou B ($31.64) retains a bullish cloud structure, but price below the cloud confirms the present short-term corrective phase. 42‑ and 52‑week volatilities at ~3% indicate relatively muted realized volatility versus typical biotech swings.

 


Fundamental Analysis

Profitability and cash: Operating income (EBIT) $108,452,000 and EBITDA $109,482,000 produce an operating margin of 52.18% and return on sales 52.18%, both consistent with the high-margin profile reflected in operating metrics. Cash and short‑term investments total $786,894,000 and cash alone $298,927,000, providing a strong liquidity buffer versus $27,245,000 total debt and a current ratio of 12.44x. Free cash flow $142,172,000 yields ~6.01% free cash flow yield on market capitalization, supporting runway and program funding.

Growth and R&D: Total revenue $207,834,000 and YoY revenue growth 28.69% show meaningful top-line expansion; research and development expense $82,993,000 underscores continued pipeline investment. Net income $119,244,000 produces EPS actual $1.33 versus an EPS estimate of -$0.55, an EPS surprise (difference) of $1.88 indicating a positive earnings variance for the reported period.

Capital structure and returns: Debt metrics remain light — debt-to-equity 0.02495 and debt-to-assets 0.02299 — while return on equity 10.92% and return on assets 10.71% indicate productive use of capital. Interest coverage ratio 4.33x signals ability to service interest expense from operating earnings.

Valuation metrics: Price/earnings at 20.28x and price/book 2.16x present a valuation below certain peer medians; price/sales 11.38x and enterprise multiple ~14.66x reflect premium expectations tied to clinical value. WMDST values the stock as under-valued given cash runway, operating profitability and near-term registrational catalysts.

Industry comparisons where provided: Operating margin (52.18%) stands above the industry peer mean (-0.84%) and median (0.42%). Price/book (2.16x) sits below the industry peer mean (6.90). Price/earnings (20.28x) sits below the industry peer median (30.96). Free cash flow yield (~6.01%) exceeds the industry peer mean (0.59%). These comparisons indicate stronger profitability and cash conversion against the industry peer mean while market multiples sit below peer central tendencies.

MOST-RECENT QUARTERLY REPORT
REPORT PERIOD ENDING: 2025-09-30
REPORT DATE: 2025-11-04
NEXT REPORT DATE: 2026-02-03
CASH FLOW  Begin Period Cash Flow 115.5 M
 Operating Cash Flow 142.2 M
 Capital Expenditures -42.00 K
 Change In Working Capital 11.7 M
 Dividends Paid
 Cash Flow Delta 184.3 M
 End Period Cash Flow 299.7 M
 
INCOME STATEMENT REVENUE
 Total Revenue 207.8 M
 Forward Revenue -34.01 M
COSTS
 Cost Of Revenue
 Depreciation 1.0 M
 Depreciation and Amortization 1.0 M
 Research and Development 83.0 M
 Total Operating Expenses 99.4 M
PROFITABILITY
 Gross Profit
 EBITDA 109.5 M
 EBIT 108.5 M
 Operating Income 108.5 M
 Interest Income 10.8 M
 Interest Expense
 Net Interest Income 10.8 M
 Income Before Tax 119.2 M
 Tax Provision
 Tax Rate 21.0 %
 Net Income 119.2 M
 Net Income From Continuing Operations 119.2 M
EARNINGS
 EPS Estimate -0.55
 EPS Actual 1.33
 EPS Difference 1.88
 EPS Surprise 341.818 %
 Forward EPS -0.89
 
BALANCE SHEET ASSETS
 Total Assets 1.2 B
 Intangible Assets
 Net Tangible Assets 1.1 B
 Total Current Assets 802.7 M
 Cash and Short-Term Investments 786.9 M
 Cash 298.9 M
 Net Receivables
 Inventory
 Long-Term Investments 805.0 K
LIABILITIES
 Accounts Payable 18.4 M
 Short-Term Debt
 Total Current Liabilities 64.5 M
 Net Debt
 Total Debt 27.2 M
 Total Liabilities 93.1 M
EQUITY
 Total Equity 1.1 B
 Retained Earnings -653.27 M
VALUATION & PER-SHARE METRICS EQUITY & PER-SHARE METRICS
 Book Value Per-Share 12.46
 Shares Outstanding 87.666 M
 Revenue Per-Share 2.37
VALUATION
 Market Capitalization 2.4 B
 Enterprise Value 1.6 B
 Enterprise Multiple 14.655
Enterprise Multiple QoQ -193.146 %
Enterprise Multiple YoY -149.007 %
Enterprise Multiple IPRWA high: 52.77
median: 28.451
IDYA: 14.655
mean: 8.453
low: -82.433
 EV/R 7.72
CAPITAL STRUCTURE
 Asset To Equity 1.085
 Asset To Liability 12.729
 Debt To Capital 0.024
 Debt To Assets 0.023
Debt To Assets QoQ -9.984 %
Debt To Assets YoY 51.649 %
Debt To Assets IPRWA high: 1.045
mean: 0.24
median: 0.181
IDYA: 0.023
low: 0.0
 Debt To Equity 0.025
Debt To Equity QoQ -9.993 %
Debt To Equity YoY 56.721 %
Debt To Equity IPRWA high: 1.461
mean: 0.342
median: 0.106
IDYA: 0.025
low: -0.897
PRICE-BASED VALUATION
 Price To Book (P/B) 2.165
Price To Book QoQ 2.798 %
Price To Book YoY -11.001 %
Price To Book IPRWA high: 16.86
mean: 6.904
median: 6.057
IDYA: 2.165
low: -8.555
 Price To Earnings (P/E) 20.276
Price To Earnings QoQ -181.484 %
Price To Earnings YoY -136.589 %
Price To Earnings IPRWA high: 56.753
median: 30.96
IDYA: 20.276
mean: 4.573
low: -93.179
 PE/G Ratio -0.081
 Price To Sales (P/S) 11.375
Price To Sales QoQ
Price To Sales YoY
Price To Sales IPRWA high: 1040.421
mean: 64.81
median: 18.442
IDYA: 11.375
low: 0.466
FORWARD MULTIPLES
Forward P/E -35.568
Forward PE/G 0.142
Forward P/S -91.015
EFFICIENCY OPERATIONAL
 Operating Leverage
ASSET & SALES
 Asset Turnover Ratio 0.187
Asset Turnover Ratio QoQ
Asset Turnover Ratio YoY
Asset Turnover Ratio IPRWA high: 0.438
IDYA: 0.187
mean: 0.119
median: 0.107
low: -0.004
 Receivables Turnover
Receivables Turnover Ratio QoQ
Receivables Turnover Ratio YoY
Receivables Turnover Ratio IPRWA
 Inventory Turnover
Inventory Turnover Ratio QoQ
Inventory Turnover Ratio YoY
Inventory Turnover Ratio IPRWA
 Days Sales Outstanding (DSO)
CASH CYCLE
 Cash Conversion Cycle Days (CCC)
Cash Conversion Cycle Days QoQ
Cash Conversion Cycle Days YoY
Cash Conversion Cycle Days IPRWA high: 520.898
median: 189.366
mean: 166.152
IDYA: 0
low: -314.885
CAPITAL DEPLOYMENT
 Cash Conversion Ratio 0.282
 CapEx To Revenue -0.0
 CapEx To Depreciation -0.041
 
CAPITAL, LIQUIDITY & COVERAGE CAPITAL STRUCTURE
 Total Capital 1.1 B
 Net Invested Capital 1.1 B
 Invested Capital 1.1 B
 Net Tangible Assets 1.1 B
 Net Working Capital 738.1 M
LIQUIDITY
 Cash Ratio 12.198
 Current Ratio 12.443
Current Ratio QoQ 0.429 %
Current Ratio YoY -45.731 %
Current Ratio IPRWA high: 25.502
IDYA: 12.443
mean: 4.03
median: 2.865
low: 0.02
 Quick Ratio
Quick Ratio QoQ
Quick Ratio YoY
Quick Ratio IPRWA
COVERAGE & LEVERAGE
 Debt To EBITDA 0.249
 Cost Of Debt 73.559 %
 Interest Coverage Ratio 4.326
Interest Coverage Ratio QoQ -222.122 %
Interest Coverage Ratio YoY -262.128 %
Interest Coverage Ratio IPRWA high: 815.709
mean: 37.741
median: 6.583
IDYA: 4.326
low: -1337.523
 Operating Cash Flow Ratio 1.882
TIMING / LIQUIDITY
 Days Payables Outstanding (DPO)
DIVIDENDS
 Dividend Coverage Ratio
 Dividend Payout Ratio
 Dividend Rate
 Dividend Yield
PERFORMANCE GROWTH
 Asset Growth Rate 13.816 %
 Revenue Growth 2869.057 %
Revenue Growth QoQ
Revenue Growth YoY
Revenue Growth IPRWA IDYA: 2869.057 %
high: 301.849 %
mean: 8.063 %
median: 4.118 %
low: -259.856 %
 Earnings Growth -251.136 %
Earnings Growth QoQ -3532.226 %
Earnings Growth YoY 2034.603 %
Earnings Growth IPRWA high: 162.5 %
median: -6.312 %
mean: -8.527 %
low: -198.545 %
IDYA: -251.136 %
MARGINS
 Gross Margin
Gross Margin QoQ
Gross Margin YoY
Gross Margin IPRWA
 EBIT Margin 52.182 %
EBIT Margin QoQ
EBIT Margin YoY
EBIT Margin IPRWA high: 3270.865 %
IDYA: 52.182 %
median: 42.305 %
mean: -84.246 %
low: -7772.481 %
 Return On Sales (ROS) 52.182 %
Return On Sales QoQ
Return On Sales YoY
Return On Sales IPRWA high: 573.037 %
IDYA: 52.182 %
median: 26.431 %
mean: -90.032 %
low: -7977.249 %
CASH FLOW
 Free Cash Flow (FCF) 142.2 M
 Free Cash Flow Yield 6.014 %
Free Cash Flow Yield QoQ -292.51 %
Free Cash Flow Yield YoY -447.429 %
Free Cash Flow Yield IPRWA high: 30.655 %
IDYA: 6.014 %
median: 1.086 %
mean: 0.588 %
low: -57.887 %
 Free Cash Growth -325.18 %
Free Cash Growth QoQ -13791.789 %
Free Cash Growth YoY -795.186 %
Free Cash Growth IPRWA high: 201.164 %
mean: 25.288 %
median: 22.832 %
low: -200.947 %
IDYA: -325.18 %
 Free Cash To Net Income 1.192
 Cash Flow Margin 58.43 %
 Cash Flow To Earnings 1.018
VALUE & RETURNS
 Economic Value Added 0.05
 Return On Assets (ROA) 10.712 %
Return On Assets QoQ -248.038 %
Return On Assets YoY -328.791 %
Return On Assets IPRWA high: 30.5 %
IDYA: 10.712 %
median: 2.314 %
mean: -1.397 %
low: -66.968 %
 Return On Capital Employed (ROCE) 9.678 %
 Return On Equity (ROE) 0.109
Return On Equity QoQ -235.22 %
Return On Equity YoY -348.724 %
Return On Equity IPRWA high: 0.948
IDYA: 0.109
median: 0.047
mean: 0.013
low: -1.385
 DuPont ROE 11.624 %
 Return On Invested Capital (ROIC) 7.846 %
Return On Invested Capital QoQ
Return On Invested Capital YoY 5.713 %
Return On Invested Capital IPRWA high: 31.965 %
IDYA: 7.846 %
median: 5.759 %
mean: 0.934 %
low: -73.241 %

Six-Week Outlook

Clinical calendar and catalysts center the near-term outlook: the company expects randomized PFS data from the OptimUM‑02 darovasertib + crizotinib registrational study in Q1 2026, creating a high‑impact information event for sentiment and repositioning.

Technically, short-term momentum shows bearish elements (MACD negative and below its signal line; price below short-term EMAs) while MRO implies potential for mean reversion because price sits below modeled target. The ADX reading indicates no dominant trend, so price reactions to the upcoming clinical readout likely dictate direction over the next six weeks.

Given robust liquidity and a low-leverage structure, fundamental capacity to execute through readouts remains intact; traders and analysts should monitor the PFS readout date and any IND/clinical-start announcements as primary catalysts that could reset technical baselines without prescriptive recommendations.

About IDEAYA Biosciences, Inc.

Ideaya Biosciences, Inc. (NASDAQ:IDYA) develops precision medicine solutions in oncology, with a particular emphasis on synthetic lethality, an innovative approach in cancer therapy. Based in South San Francisco, California, the company targets genetically defined patient populations through its pipeline of therapeutic candidates. Notable among these are IDE196, a Phase 2/3 protein kinase C inhibitor for cancers with GNAQ or GNA11 mutations, and IDE397, a Phase 1/2 inhibitor addressing solid tumors with specific gene deletions. Ideaya collaborates with industry leaders such as GlaxoSmithKline, Pfizer, and Novartis, which enhances its drug discovery and development capabilities. The company employs advanced technologies, including the DECIPHER dual CRISPR library and INQUIRE chemical library, to identify new therapeutic targets and biomarkers. Ideaya’s approach to cancer treatment involves not only drug development but also a deep understanding of the genetic and molecular mechanisms of cancer. This strategy aims to provide more effective, personalized therapies, offering new treatment possibilities for patients facing difficult cancer types.



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