Recent News
Nov 3, 2025 — Investors Business Daily reported Agios cleared a technical RS threshold, lifting its RS Rating to 81 and noting recent sales growth; Oct 30, 2025 — multiple outlets covered Agios’ scheduled Q3 2025 results release and related investor materials (company webcast announced Oct 16).
Technical Analysis
ADX stands at 22.3, indicating an emerging trend strength; coupled with the directional indicators, trend strength now matters for short-term direction.
DI+ at 25.9 shows a peak-and-reversal, which signals bearish directional pressure; DI- at 19.68 shows a dip-and-reversal, reinforcing bearish directional pressure.
MACD sits at 0.81 below its 0.99 signal and displays a peak-and-reversal, indicating bearish momentum in the oscillator despite a positive absolute MACD value.
MRO reads -6.2, which places price below the WMDST target and implies upside potential from a valuation gap; the MRO trend shows a peak-and-reversal, reducing near-term upside momentum.
RSI at 55.47 with a peak-and-reversal shows the oscillator backing away from recent strength while remaining in neutral territory — short-term momentum weakened without oversold conditions.
Price trades at $40.13, below the 20-day average ($42.39) and under the 1x Bollinger lower band ($41.29), indicating short-term weakness versus recent volatility; price remains above the 200-day average ($34.72), which supports a longer-term recovery context.
Short-term EMAs show pressure: the 12-day EMA at $42.16 carries a peak-and-reversal, and the 26-day EMA at $41.39 sits above the close, signaling near-term bearish bias against longer-term averages.
Ichimoku components place the cloud (Senkou A/B: $36.93 / $34.24) below current price, which provides structural support beneath current levels; the Kijun at $40.32 sits near the close and can act as a short-term reference.
Volume at 834,696 exceeds the 10-day average (573,486) and the 50/200-day averages, suggesting recent directional moves carried meaningful participation and that short-term directional signals warrant attention.
Fundamental Analysis
Total revenue registers $12,455,000 for the period; YoY revenue growth equals 721.49% while the reported revenue growth metric shows 42.73% (both values provided). Product sales growth underpins the beat versus consensus reported alongside the quarter.
EPS came in at -$1.78 versus an estimate of -$1.90, a positive surprise of $0.12 or +6.32% versus estimates; the narrower-than-expected loss reflects revenue upside and controlled non‑recurring items.
Operating performance remains loss-making: EBIT stands at -$127,056,000 and EBIT margin at -10.20%. The EBIT margin sits below the industry peer mean of -0.73% and below the industry peer median of 0.24%, indicating profitability lags typical peer margins despite progress on revenue.
Liquidity and balance-sheet strength stand out: cash and short-term investments total $938,937,000 and cash alone $80,871,000; current ratio 14.48 and quick ratio 14.04 signal ample near-term coverage of liabilities.
Leverage stays low: total debt $48,760,000 with debt-to-assets at 3.31% and debt-to-equity at 3.56%, well inside the industry peer range and consistent with a conservative capital structure.
Cash flow dynamics show operating cash flow of -$77,124,000 and free cash flow of -$87,999,000, yielding a free cash flow yield of -4.18%; free cash flow remains negative as investment and commercialization ramping continue.
Gross margin at 86.34% outperforms the industry peer mean, supporting strong product-level economics on existing revenue streams.
Key growth and efficiency metrics: receivables turnover 2.99 and asset turnover very low at 0.82% (asset turnover sits well below the industry peer mean of 11.54%), reflecting a commercial-stage company with concentrated product revenue and large asset base.
Earnings growth shows positive momentum numerically (earnings growth +24.52% and QoQ strength), but absolute profitability remains negative and influenced by R&D and SG&A investments for pipeline expansion.
Valuation context: price-to-book at 1.54 sits below the industry peer mean of 5.29; price-to-sales at 169.18 stands above the industry peer mean of 56.00, reflecting low revenue base versus market capitalization. WMDST values the stock as under-valued.
MOST-RECENT QUARTERLY REPORT
| REPORT PERIOD ENDING: | 2025-06-30 |
| REPORT DATE: | 2025-10-30 |
| NEXT REPORT DATE: | 2026-01-29 |
| CASH FLOW | Begin Period Cash Flow | $ 79.0 M |
| Operating Cash Flow | $ -77.12 M | |
| Capital Expenditures | $ -10.88 M | |
| Change In Working Capital | $ 8.3 M | |
| Dividends Paid | — | |
| Cash Flow Delta | $ 1.9 M | |
| End Period Cash Flow | $ 80.9 M | |
| INCOME STATEMENT | REVENUE | |
| Total Revenue | $ 12.5 M | |
| Forward Revenue | $ 2.5 M | |
| COSTS | ||
| Cost Of Revenue | $ 1.7 M | |
| Depreciation | $ 1.3 M | |
| Depreciation and Amortization | $ 1.3 M | |
| Research and Development | $ 91.9 M | |
| Total Operating Expenses | $ 139.5 M | |
| PROFITABILITY | ||
| Gross Profit | $ 10.8 M | |
| EBITDA | $ -125.80 M | |
| EBIT | $ -127.06 M | |
| Operating Income | $ -127.06 M | |
| Interest Income | $ 14.5 M | |
| Interest Expense | — | |
| Net Interest Income | $ 14.5 M | |
| Income Before Tax | $ -112.02 M | |
| Tax Provision | — | |
| Tax Rate | — | |
| Net Income | $ -112.02 M | |
| Net Income From Continuing Operations | $ -112.02 M | |
| EARNINGS | ||
| EPS Estimate | $ -1.90 | |
| EPS Actual | $ -1.78 | |
| EPS Difference | $ 0.12 | |
| EPS Surprise | 6.316 % | |
| Forward EPS | $ -1.52 | |
| BALANCE SHEET | ASSETS | |
| Total Assets | $ 1.5 B | |
| Intangible Assets | — | |
| Net Tangible Assets | $ 1.4 B | |
| Total Current Assets | $ 1.0 B | |
| Cash and Short-Term Investments | $ 938.9 M | |
| Cash | $ 80.9 M | |
| Net Receivables | $ 5.0 M | |
| Inventory | $ 30.8 M | |
| Long-Term Investments | $ 3.9 M | |
| LIABILITIES | ||
| Accounts Payable | $ 17.5 M | |
| Short-Term Debt | — | |
| Total Current Liabilities | $ 70.4 M | |
| Net Debt | — | |
| Total Debt | $ 48.8 M | |
| Total Liabilities | $ 101.7 M | |
| EQUITY | ||
| Total Equity | $ 1.4 B | |
| Retained Earnings | $ -350.23 M | |
| VALUATION & PER-SHARE METRICS | EQUITY & PER-SHARE METRICS | |
| Book Value Per-Share | $ 23.60 | |
| Shares Outstanding | 58.039 M | |
| Revenue Per-Share | $ 0.21 | |
| VALUATION | Market Capitalization | $ 2.1 B |
| Enterprise Value | $ 1.2 B | |
| Enterprise Multiple | -9.674 | |
| Enterprise Multiple QoQ | 5.127 % | |
| Enterprise Multiple YoY | -45.507 % | |
| Enterprise Multiple IPRWA | high: 47.216 median: 14.143 mean: 5.461 AGIO: -9.674 low: -68.907 |
|
| EV/R | 97.707 | |
| CAPITAL STRUCTURE | ||
| Asset To Equity | 1.074 | |
| Asset To Liability | 14.469 | |
| Debt To Capital | 0.034 | |
| Debt To Assets | 0.033 | |
| Debt To Assets QoQ | -2.615 % | |
| Debt To Assets YoY | -19.23 % | |
| Debt To Assets IPRWA | high: 0.995 mean: 0.187 median: 0.062 AGIO: 0.033 low: 0.0 |
|
| Debt To Equity | 0.036 | |
| Debt To Equity QoQ | -1.385 % | |
| Debt To Equity YoY | -25.864 % | |
| Debt To Equity IPRWA | high: 1.706 mean: 0.25 median: 0.059 AGIO: 0.036 low: -1.039 |
|
| PRICE-BASED VALUATION | ||
| Price To Book (P/B) | 1.539 | |
| Price To Book QoQ | 24.667 % | |
| Price To Book YoY | -57.452 % | |
| Price To Book IPRWA | high: 16.592 median: 6.295 mean: 5.286 AGIO: 1.539 low: -10.064 |
|
| Price To Earnings (P/E) | -18.266 | |
| Price To Earnings QoQ | -9.445 % | |
| Price To Earnings YoY | -26.49 % | |
| Price To Earnings IPRWA | high: 44.732 mean: -11.199 median: -13.453 AGIO: -18.266 low: -73.374 |
|
| PE/G Ratio | -0.745 | |
| Price To Sales (P/S) | 169.179 | |
| Price To Sales QoQ | -18.434 % | |
| Price To Sales YoY | -38.977 % | |
| Price To Sales IPRWA | high: 517.227 AGIO: 169.179 mean: 56.005 median: 19.711 low: 0.25 |
|
| FORWARD MULTIPLES | ||
| Forward P/E | -21.116 | |
| Forward PE/G | -0.861 | |
| Forward P/S | 859.293 | |
| EFFICIENCY | OPERATIONAL | |
| Operating Leverage | 0.448 | |
| ASSET & SALES | ||
| Asset Turnover Ratio | 0.008 | |
| Asset Turnover Ratio QoQ | 51.845 % | |
| Asset Turnover Ratio YoY | -22.505 % | |
| Asset Turnover Ratio IPRWA | high: 0.388 mean: 0.115 median: 0.113 AGIO: 0.008 low: -0.001 |
|
| Receivables Turnover | 2.99 | |
| Receivables Turnover Ratio QoQ | 27.707 % | |
| Receivables Turnover Ratio YoY | 25.222 % | |
| Receivables Turnover Ratio IPRWA | high: 6.517 AGIO: 2.99 median: 1.422 mean: 1.405 low: 0.012 |
|
| Inventory Turnover | 0.056 | |
| Inventory Turnover Ratio QoQ | 48.497 % | |
| Inventory Turnover Ratio YoY | -11.476 % | |
| Inventory Turnover Ratio IPRWA | high: 2.946 mean: 0.607 median: 0.434 AGIO: 0.056 low: 0.006 |
|
| Days Sales Outstanding (DSO) | 30.514 | |
| CASH CYCLE | ||
| Cash Conversion Cycle Days (CCC) | 1258.184 | |
| Cash Conversion Cycle Days QoQ | 24.414 % | |
| Cash Conversion Cycle Days YoY | -34.362 % | |
| Cash Conversion Cycle Days IPRWA | AGIO: 1258.184 high: 1140.813 median: 205.05 mean: 199.777 low: -1350.846 |
|
| CAPITAL DEPLOYMENT | ||
| Cash Conversion Ratio | 0.013 | |
| CapEx To Revenue | -0.873 | |
| CapEx To Depreciation | -8.638 | |
| CAPITAL, LIQUIDITY & COVERAGE | CAPITAL STRUCTURE | |
| Total Capital | $ 1.4 B | |
| Net Invested Capital | $ 1.4 B | |
| Invested Capital | $ 1.4 B | |
| Net Tangible Assets | $ 1.4 B | |
| Net Working Capital | $ 949.1 M | |
| LIQUIDITY | ||
| Cash Ratio | 13.335 | |
| Current Ratio | 14.479 | |
| Current Ratio QoQ | -21.723 % | |
| Current Ratio YoY | 43.471 % | |
| Current Ratio IPRWA | high: 25.128 AGIO: 14.479 mean: 3.916 median: 2.52 low: 0.021 |
|
| Quick Ratio | 14.041 | |
| Quick Ratio QoQ | -21.698 % | |
| Quick Ratio YoY | 44.606 % | |
| Quick Ratio IPRWA | AGIO: 14.041 high: 10.544 mean: 2.948 median: 2.158 low: 0.021 |
|
| COVERAGE & LEVERAGE | ||
| Debt To EBITDA | -0.388 | |
| Cost Of Debt | 0.018 % | |
| Interest Coverage Ratio | -12705.6 | |
| Interest Coverage Ratio QoQ | 19.157 % | |
| Interest Coverage Ratio YoY | 20.071 % | |
| Interest Coverage Ratio IPRWA | high: 940.414 mean: 45.392 median: 2.742 low: -1465.352 AGIO: -12705.6 |
|
| Operating Cash Flow Ratio | -1.56 | |
| TIMING / LIQUIDITY | ||
| Days Payables Outstanding (DPO) | 1314.421 | |
| DIVIDENDS | ||
| Dividend Coverage Ratio | — | |
| Dividend Payout Ratio | — | |
| Dividend Rate | — | |
| Dividend Yield | — | |
| PERFORMANCE | GROWTH | |
| Asset Growth Rate | -5.418 % | |
| Revenue Growth | 42.734 % | |
| Revenue Growth QoQ | -328.805 % | |
| Revenue Growth YoY | 721.492 % | |
| Revenue Growth IPRWA | high: 269.352 % AGIO: 42.734 % mean: 20.376 % median: 12.272 % low: -259.856 % |
|
| Earnings Growth | 24.516 % | |
| Earnings Growth QoQ | 220.932 % | |
| Earnings Growth YoY | 48.115 % | |
| Earnings Growth IPRWA | high: 155.0 % AGIO: 24.516 % median: 11.33 % mean: 2.353 % low: -181.25 % |
|
| MARGINS | ||
| Gross Margin | 86.335 % | |
| Gross Margin QoQ | -1.406 % | |
| Gross Margin YoY | 4.462 % | |
| Gross Margin IPRWA | high: 100.0 % AGIO: 86.335 % median: 80.103 % mean: 77.812 % low: -77.751 % |
|
| EBIT Margin | -1020.12 % | |
| EBIT Margin QoQ | -16.518 % | |
| EBIT Margin YoY | -16.948 % | |
| EBIT Margin IPRWA | high: 338.783 % median: 23.755 % mean: -73.27 % AGIO: -1020.12 % low: -5123.44 % |
|
| Return On Sales (ROS) | -1020.12 % | |
| Return On Sales QoQ | -16.518 % | |
| Return On Sales YoY | -16.948 % | |
| Return On Sales IPRWA | high: 89.247 % median: 28.85 % mean: -77.093 % AGIO: -1020.12 % low: -5698.0 % |
|
| CASH FLOW | ||
| Free Cash Flow (FCF) | $ -88.00 M | |
| Free Cash Flow Yield | -4.176 % | |
| Free Cash Flow Yield QoQ | -32.667 % | |
| Free Cash Flow Yield YoY | 37.098 % | |
| Free Cash Flow Yield IPRWA | high: 36.371 % median: 0.516 % mean: -0.332 % AGIO: -4.176 % low: -74.318 % |
|
| Free Cash Growth | -21.608 % | |
| Free Cash Growth QoQ | 32.475 % | |
| Free Cash Growth YoY | -20.731 % | |
| Free Cash Growth IPRWA | high: 157.51 % median: 13.562 % mean: 3.883 % AGIO: -21.608 % low: -183.577 % |
|
| Free Cash To Net Income | 0.786 | |
| Cash Flow Margin | -881.895 % | |
| Cash Flow To Earnings | 0.981 | |
| VALUE & RETURNS | ||
| Economic Value Added | — | |
| Return On Assets (ROA) | -7.402 % | |
| Return On Assets QoQ | 33.417 % | |
| Return On Assets YoY | -37.515 % | |
| Return On Assets IPRWA | high: 36.544 % median: 1.616 % mean: -1.385 % AGIO: -7.402 % low: -68.545 % |
|
| Return On Capital Employed (ROCE) | -9.07 % | |
| Return On Equity (ROE) | -0.082 | |
| Return On Equity QoQ | 34.346 % | |
| Return On Equity YoY | -43.795 % | |
| Return On Equity IPRWA | high: 1.117 median: 0.04 mean: 0.008 AGIO: -0.082 low: -1.572 |
|
| DuPont ROE | -7.9 % | |
| Return On Invested Capital (ROIC) | — | |
| Return On Invested Capital QoQ | — | |
| Return On Invested Capital YoY | — | |
| Return On Invested Capital IPRWA | — | |