Semler Scientific, Inc. (NASDAQ:SMLR) Transitions Into Bitcoin-Centric Combined Company Post-Acquisition

Acquisition activity and a bitcoin-heavy treasury strategy reshape Semler’s near-term operating context while core diagnostics revenue shows continued pressure. Market structure and momentum place short-term direction in tension with directional indicators.

Recent News

On September 22, 2025, Strive announced an all-stock acquisition of Semler Scientific valued at approximately $1.34 billion, exchanging 21.04 Strive Class A shares per Semler share and signaling combined company control of a substantially larger bitcoin treasury. The transaction positions Semler’s diagnostics business inside a bitcoin-focused corporate structure.

Technical Analysis

Trend Strength (ADX): ADX at 25.73 signals a strong trend environment; that strength increases the likelihood that directional signals will carry price action into the near term rather than fade quickly.

Directional Indicators (DI+/DI-): DI+ shows a dip & reversal, a bullish sign, while DI- shows a peak & reversal, which also reads bullish; together they indicate buyers regained directional control, reinforcing the ADX strength for an upward directional bias.

MACD: MACD reads -1.05 with a MACD signal at -1.25 and a peak & reversal trend, which indicates bearish momentum; concurrently MACD sits above its signal line, producing a short-term bullish crossover that suggests momentum may attempt a transient recovery despite the recent peak-and-reverse behavior.

MRO (Momentum/Regression Oscillator): MRO at 14.59 sits positive, which implies price sits above the model target and faces probable downward pressure toward that target; the positive MRO raises the risk of a pullback from current levels.

RSI: RSI at 41.44 with a dip & reversal indicates momentum softened and began to recover; remaining below 50 keeps the momentum profile tilted toward sellers compared with typical bullish ranges.

Price vs. Moving Averages & Ichimoku: Price closed at $24.61, below the 20-day ($25.07), 50-day ($28.28) and 200-day ($36.86) averages; Ichimoku Tenkan ($27.64), Kijun ($28.29) and cloud levels (Senkou A $31.57 / Senkou B $37.92) sit above price, producing a bearish price structure that contrasts with the directional indicator recovery.

Bollinger Bands, Volatility & Volume: Price trades between the lower 1σ band ($22.48) and the middle band ($25.07), nearer the lower band, which leaves room for either a volatility-driven bounce or further decline; daily volume at 574,426 sits below the 10- and 50-day averages, suggesting low participation that can amplify intraday moves when volume reappears.

 


Fundamental Analysis

Revenue & Margins: Total revenue totaled $8,217,000 with gross profit $7,478,000, producing a gross margin of 91.01%. Operating (EBIT) margin measured -24.99%, a QoQ change of -97.01% and a YoY change of -167.55%. Operating margin sits well below the industry peer mean of 18.49% and the industry peer median of 17.48%.

Profitability & Returns: Net income reached $66,933,000 while operating income registered -$2,053,000, producing ROE of 17.46% and ROA of 16.40%. These positive returns contrast with negative operating margins, indicating non-operating gains materially influenced net results for the period.

Cash Flow & Capital Structure: Operating cash flow recorded $514,000 while free cash flow reached -$149,154,000 and free cash flow yield measured -30.59%. Cash and short-term investments totaled $13,482,000 against total debt $96,279,000 and net debt $82,773,000, yielding a cash ratio of 0.37 and a current ratio of 0.60—liquidity metrics below typical healthy thresholds.

Valuation Multiples: Market capitalization stood at $487,676,257 with enterprise value $570,473,257, producing an EV/revenue (EVR) of 69.43x. Price-to-sales at 59.35x and price-to-book at 1.27x; forward PE registers 44.14x on a forward EPS of $0.8425. Enterprise multiple and several multiples reflect unusually high valuation relative to trailing revenue and negative operating margins.

EPS & Forecasts: Reported EPS came in at -$0.23 versus an estimate of -$0.27, an EPS surprise of +14.82%. Forward EPS projects $0.8425, implying expected profitability recovery versus the trailing quarter loss.

Balance Of Metrics: Asset turnover reads 0.02 and revenue growth measured -6.99% YoY with QoQ contraction of -75.73%. Intangible assets total $496,865,000 and net tangible assets sit negative at -$113,456,000. These structural metrics, combined with negative free cash flow and concentrated treasury positioning, shape valuation stress despite strong gross margin and positive reported net income.

Valuation Conclusion: The current valuation as determined by WMDST registers as over-valued, driven by high EV/revenue and price-to-sales multiples alongside negative operating margins and a large negative free cash flow position.

MOST-RECENT QUARTERLY REPORT
REPORT PERIOD ENDING: 2025-06-30
REPORT DATE: 2025-08-04
NEXT REPORT DATE: 2025-11-11
CASH FLOW  Begin Period Cash Flow 9.9 M
 Operating Cash Flow 514.0 K
 Capital Expenditures -149.67 M
 Change In Working Capital 1.5 M
 Dividends Paid
 Cash Flow Delta 3.7 M
 End Period Cash Flow 13.6 M
 
INCOME STATEMENT REVENUE
 Total Revenue 8.2 M
 Forward Revenue 353.9 K
COSTS
 Cost Of Revenue 739.0 K
 Depreciation 109.0 K
 Depreciation and Amortization 109.0 K
 Research and Development 1.2 M
 Total Operating Expenses 10.3 M
PROFITABILITY
 Gross Profit 7.5 M
 EBITDA -1.94 M
 EBIT -2.05 M
 Operating Income -2.05 M
 Interest Income
 Interest Expense
 Net Interest Income -1.15 M
 Income Before Tax 80.6 M
 Tax Provision 13.6 M
 Tax Rate 16.918 %
 Net Income 66.9 M
 Net Income From Continuing Operations 66.9 M
EARNINGS
 EPS Estimate -0.27
 EPS Actual -0.23
 EPS Difference 0.04
 EPS Surprise 14.815 %
 Forward EPS 0.84
 
BALANCE SHEET ASSETS
 Total Assets 522.6 M
 Intangible Assets 496.9 M
 Net Tangible Assets -113.46 M
 Total Current Assets 21.9 M
 Cash and Short-Term Investments 13.5 M
 Cash 13.5 M
 Net Receivables 2.8 M
 Inventory 558.0 K
 Long-Term Investments
LIABILITIES
 Accounts Payable 156.0 K
 Short-Term Debt
 Total Current Liabilities 36.8 M
 Net Debt 82.8 M
 Total Debt 96.3 M
 Total Liabilities 139.2 M
EQUITY
 Total Equity 383.4 M
 Retained Earnings 102.9 M
VALUATION & PER-SHARE METRICS EQUITY & PER-SHARE METRICS
 Book Value Per-Share 28.01
 Shares Outstanding 13.688 M
 Revenue Per-Share 0.60
VALUATION
 Market Capitalization 487.7 M
 Enterprise Value 570.5 M
 Enterprise Multiple -293.453
Enterprise Multiple QoQ 4696.831 %
Enterprise Multiple YoY -859.043 %
Enterprise Multiple IPRWA high: 123.29
median: 110.415
mean: 93.997
low: -147.649
SMLR: -293.453
 EV/R 69.426
CAPITAL STRUCTURE
 Asset To Equity 1.363
 Asset To Liability 3.755
 Debt To Capital 0.201
 Debt To Assets 0.184
Debt To Assets QoQ -43.769 %
Debt To Assets YoY 16801.835 %
Debt To Assets IPRWA high: 0.843
mean: 0.299
median: 0.292
SMLR: 0.184
low: 0.0
 Debt To Equity 0.251
Debt To Equity QoQ -57.77 %
Debt To Equity YoY 21362.393 %
Debt To Equity IPRWA high: 3.369
mean: 0.631
median: 0.579
SMLR: 0.251
low: -0.395
PRICE-BASED VALUATION
 Price To Book (P/B) 1.272
Price To Book QoQ -43.674 %
Price To Book YoY -56.022 %
Price To Book IPRWA high: 16.759
median: 6.869
mean: 6.29
SMLR: 1.272
low: -5.981
 Price To Earnings (P/E) -167.592
Price To Earnings QoQ
Price To Earnings YoY -430.541 %
Price To Earnings IPRWA high: 249.6
mean: 136.697
median: 121.658
low: -163.125
SMLR: -167.592
 PE/G Ratio
 Price To Sales (P/S) 59.35
Price To Sales QoQ 43.614 %
Price To Sales YoY 278.61 %
Price To Sales IPRWA high: 73.117
SMLR: 59.35
mean: 32.417
median: 24.499
low: 0.6
FORWARD MULTIPLES
Forward P/E 44.137
Forward PE/G
Forward P/S 1377.835
EFFICIENCY OPERATIONAL
 Operating Leverage 13.899
ASSET & SALES
 Asset Turnover Ratio 0.02
Asset Turnover Ratio QoQ -39.209 %
Asset Turnover Ratio YoY -88.26 %
Asset Turnover Ratio IPRWA high: 0.412
median: 0.124
mean: 0.121
SMLR: 0.02
low: 0.008
 Receivables Turnover 2.753
Receivables Turnover Ratio QoQ 17.105 %
Receivables Turnover Ratio YoY 29.427 %
Receivables Turnover Ratio IPRWA high: 3.133
SMLR: 2.753
mean: 1.734
median: 1.672
low: 0.374
 Inventory Turnover 1.593
Inventory Turnover Ratio QoQ -38.129 %
Inventory Turnover Ratio YoY -49.682 %
Inventory Turnover Ratio IPRWA high: 2.014
SMLR: 1.593
mean: 0.647
median: 0.568
low: 0.084
 Days Sales Outstanding (DSO) 33.148
CASH CYCLE
 Cash Conversion Cycle Days (CCC) 42.011
Cash Conversion Cycle Days QoQ 8.454 %
Cash Conversion Cycle Days YoY -13.577 %
Cash Conversion Cycle Days IPRWA high: 448.876
mean: 171.044
median: 167.784
SMLR: 42.011
low: -175.55
CAPITAL DEPLOYMENT
 Cash Conversion Ratio -0.552
 CapEx To Revenue -18.214
 CapEx To Depreciation -1373.101
 
CAPITAL, LIQUIDITY & COVERAGE CAPITAL STRUCTURE
 Total Capital 479.7 M
 Net Invested Capital 479.7 M
 Invested Capital 479.7 M
 Net Tangible Assets -113.46 M
 Net Working Capital -14.87 M
LIQUIDITY
 Cash Ratio 0.367
 Current Ratio 0.596
Current Ratio QoQ 15.11 %
Current Ratio YoY -84.002 %
Current Ratio IPRWA high: 19.146
mean: 2.55
median: 1.718
SMLR: 0.596
low: 0.027
 Quick Ratio 0.58
Quick Ratio QoQ 14.47 %
Quick Ratio YoY -84.153 %
Quick Ratio IPRWA high: 12.697
mean: 1.881
median: 1.167
SMLR: 0.58
low: 0.315
COVERAGE & LEVERAGE
 Debt To EBITDA -49.526
 Cost Of Debt 0.814 %
 Interest Coverage Ratio -2.177
Interest Coverage Ratio QoQ -97.223 %
Interest Coverage Ratio YoY -115.341 %
Interest Coverage Ratio IPRWA high: 52.298
mean: 15.468
median: 11.456
SMLR: -2.177
low: -88.481
 Operating Cash Flow Ratio 1.815
TIMING / LIQUIDITY
 Days Payables Outstanding (DPO) 36.325
DIVIDENDS
 Dividend Coverage Ratio
 Dividend Payout Ratio
 Dividend Rate
 Dividend Yield
PERFORMANCE GROWTH
 Asset Growth Rate 78.09 %
 Revenue Growth -6.995 %
Revenue Growth QoQ -75.733 %
Revenue Growth YoY -22.639 %
Revenue Growth IPRWA high: 26.158 %
median: 8.281 %
mean: 6.323 %
SMLR: -6.995 %
low: -19.222 %
 Earnings Growth
Earnings Growth QoQ
Earnings Growth YoY
Earnings Growth IPRWA
MARGINS
 Gross Margin 91.006 %
Gross Margin QoQ 1.803 %
Gross Margin YoY -0.348 %
Gross Margin IPRWA SMLR: 91.006 %
high: 87.706 %
median: 63.683 %
mean: 62.17 %
low: -7.085 %
 EBIT Margin -24.985 %
EBIT Margin QoQ -97.014 %
EBIT Margin YoY -167.553 %
EBIT Margin IPRWA high: 33.709 %
mean: 18.486 %
median: 17.478 %
SMLR: -24.985 %
low: -200.872 %
 Return On Sales (ROS) -24.985 %
Return On Sales QoQ -97.014 %
Return On Sales YoY -167.553 %
Return On Sales IPRWA high: 39.857 %
mean: 18.891 %
median: 18.374 %
SMLR: -24.985 %
low: -215.416 %
CASH FLOW
 Free Cash Flow (FCF) -149.15 M
 Free Cash Flow Yield -30.585 %
Free Cash Flow Yield QoQ 20.314 %
Free Cash Flow Yield YoY 26.015 %
Free Cash Flow Yield IPRWA high: 4.685 %
median: 0.712 %
mean: 0.676 %
low: -19.501 %
SMLR: -30.585 %
 Free Cash Growth 60.699 %
Free Cash Growth QoQ -428.653 %
Free Cash Growth YoY -105.554 %
Free Cash Growth IPRWA high: 310.383 %
mean: 85.462 %
SMLR: 60.699 %
median: 14.619 %
low: -376.098 %
 Free Cash To Net Income -2.228
 Cash Flow Margin 812.073 %
 Cash Flow To Earnings 0.997
VALUE & RETURNS
 Economic Value Added 0.04
 Return On Assets (ROA) 16.404 %
Return On Assets QoQ -167.601 %
Return On Assets YoY 126084.615 %
Return On Assets IPRWA SMLR: 16.404 %
high: 5.547 %
mean: 1.733 %
median: 1.686 %
low: -35.697 %
 Return On Capital Employed (ROCE) -0.423 %
 Return On Equity (ROE) 0.175
Return On Equity QoQ -143.623 %
Return On Equity YoY 124592.857 %
Return On Equity IPRWA SMLR: 0.175
high: 0.11
median: 0.032
mean: 0.028
low: -0.524
 DuPont ROE 24.56 %
 Return On Invested Capital (ROIC) -0.356 %
Return On Invested Capital QoQ -98.564 %
Return On Invested Capital YoY -98.876 %
Return On Invested Capital IPRWA high: 5.672 %
median: 2.571 %
mean: 2.223 %
SMLR: -0.356 %
low: -19.888 %

Six-Week Outlook

Directional indicators favor buyers while momentum and price structure favor sellers; expect heightened volatility as acquisition-related headlines and low participation drive directional bursts. Short-term moves will likely hinge on whether buyers can lift price above the 20-day average (~$25.07) and the price 12-day EMA (~$25.79); failure to regain those levels should increase downside pressure toward the lower Bollinger band (~$22.48). Given high event sensitivity and thin volume, traders should expect rapid swings rather than calm, trend-confirming progress.

About Semler Scientific, Inc.

Semler Scientific, Inc. (NASDAQ:SMLR) develops technology solutions aimed at enhancing the clinical effectiveness and efficiency of healthcare providers across the United States. The company produces QuantaFlo, a quick and efficient in-office test that measures blood flow, assisting healthcare professionals in assessing patients’ vascular conditions. Additionally, Semler Scientific offers Insulin Insights, a software tool designed to help healthcare providers optimize outpatient insulin dosing. Their products cater to a wide range of medical professionals, including cardiologists, internists, nephrologists, endocrinologists, podiatrists, and family practitioners. The company also serves healthcare insurance plans, integrated delivery networks, independent physician groups, and various entities contracting within the healthcare sector, such as risk assessment groups and retailers. Semler Scientific distributes its products through a network of sales representatives and distributors. Founded in 2007, the company is headquartered in Santa Clara, California.



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