Celldex Therapeutics, Inc (NASDAQ:CLDX) Advances Toward Near-Term Catalysts With Positive Trial Updates

Clinical-stage momentum and a heavy cash position place the company under the spotlight as multiple trial readouts and corporate updates approach. Recent Phase 2 data and corporate filings compress the information set ahead of forthcoming Phase 3 topline milestones.

Recent News

On July 21, 2026 Celldex released topline results from a Phase 2 study of barzolvolimab in prurigo nodularis. On June 10, 2026 the company announced multiple upcoming presentations from its mast cell–targeting pipeline at a major allergy congress. On June 25, 2026 stockholders approved an amendment increasing shares available under the 2021 equity incentive plan. On July 15, 2026 Celldex disclosed plans for its CFO to retire in 2027. On August 6, 2026 the company reported second‑quarter 2026 financial results and provided a corporate update that reiterated Phase 3 timelines and program priorities.

Technical Analysis

ADX Strength: ADX at 25.66 signals a strong directional regime; that strength raises the probability that recent catalyst-driven moves sustain short-term follow-through rather than immediately reverting.

Directional Indicators: DI+ peaked and reversed, a bearish signal, while DI- shows an increasing reading; those combined directional reads favor downside pressure against the current valuation and imply risk of follow‑through selling if catalysts disappoint.

MACD Momentum: MACD stands at 1.11 below its signal line at 1.39 and the MACD trend is decreasing, indicating weakening upside momentum and a bearish momentum profile into near-term event windows.

MRO Positioning: MRO at 29.19 and decreasing indicates the market price sits above the model target with moderate-to-strong potential for downward mean reversion; that dynamic amplifies downside risk if clinical updates miss expectations.

RSI & Price Context: RSI of 59.9 and falling shows reduced upside breadth from recent highs. Price closed at $41.22, below the 20‑day average of $41.97 but above the 50‑day and 200‑day averages, placing the stock between short-term resistance and longer-term support levels.

EMA / Ichimoku / Bands: The 12‑day EMA peaked and reversed while the Ichimoku Tenkan sits above price and Kijun below price; this mixed set suggests short-term topping pressure within a broader bullish cloud context. Bollinger bands place the close nearer the lower band, increasing the chance of a volatility expansion around upcoming news.

 


Fundamental Analysis

Profitability & Margins: Operating income equals -$80,623,000 and operating margin registers -3,664.68%, reflecting very low reported revenue ($22,000) against ongoing R&D and operating spend. QoQ operating margin moved -34.90% (decline), while YoY operating margin improved by 40.89% year-over-year.

Revenue & Growth: Total revenue reported $22,000 with YoY revenue growth of 8.27% and QoQ revenue change of -153.27% (reflecting period-to-period base effects). The company shows revenue growth but on a very small revenue base relative to expenses and market cap.

Cash and Liquidity: Cash and short-term investments total $717,587,000 and the cash ratio sits at 1,170.14% (11.70138), with a current ratio of 1,182.11% (11.82113), indicating ample liquidity to fund operations and clinical programs through the near term as reported.

Cash Flow: Operating cash flow totaled -$57,410,000 and free cash flow reached -$60,589,000; free cash flow yield equals -2.22%, with QoQ deterioration in cash generation noted in the provided metrics.

Capital Structure: Total debt remains low at $4,904,000, producing a debt-to-assets ratio of 0.63% and debt-to-equity of 0.69%, reflecting a largely equity-funded balance sheet and minimal leverage relative to invested capital.

Earnings & Valuation Metrics: GAAP EPS was -$0.94 versus an estimate of -$1.06, representing an EPS surprise of +$0.12 or +11.32%. Price-to-book at 3.83 sits below the industry peer mean and median book multiples, while the PEG ratio at 1.82 sits above the industry peer mean. The P/E stands negative at -37.06 due to losses. The price-to-sales ratio is extreme (reported as ~124,319x) driven by the very small revenue base.

WMDST Valuation: The current valuation as determined by WMDST rates the stock as over-valued; the designation aligns with a high market capitalization versus minimal reported revenue, negative operating cash flow, and elevated forward multiples.

MOST-RECENT QUARTERLY REPORT
REPORT PERIOD ENDING: 2026-06-30
REPORT DATE: 2026-08-06
NEXT REPORT DATE: 2026-11-05
CASH FLOW  Begin Period Cash Flow 35.7 M
 Operating Cash Flow -57.41 M
 Capital Expenditures -3.18 M
 Change In Working Capital 8.5 M
 Dividends Paid
 Cash Flow Delta 11.7 M
 End Period Cash Flow 47.5 M
 
INCOME STATEMENT REVENUE
 Total Revenue 22.0 K
 Forward Revenue 6.1 K
COSTS
 Cost Of Revenue
 Depreciation 902.0 K
 Depreciation and Amortization 902.0 K
 Research and Development 67.5 M
 Total Operating Expenses 80.6 M
PROFITABILITY
 Gross Profit
 EBITDA -79.72 M
 EBIT -80.62 M
 Operating Income -80.62 M
 Interest Income
 Interest Expense
 Net Interest Income
 Income Before Tax -73.50 M
 Tax Provision
 Tax Rate
 Net Income -73.50 M
 Net Income From Continuing Operations -73.50 M
EARNINGS
 EPS Estimate -1.06
 EPS Actual -0.94
 EPS Difference 0.12
 EPS Surprise 11.321 %
 Forward EPS -1.04
 
BALANCE SHEET ASSETS
 Total Assets 782.3 M
 Intangible Assets 27.2 M
 Net Tangible Assets 687.4 M
 Total Current Assets 724.9 M
 Cash and Short-Term Investments 717.6 M
 Cash 47.5 M
 Net Receivables 230.0 K
 Inventory
 Long-Term Investments 634.0 K
LIABILITIES
 Accounts Payable 14.7 M
 Short-Term Debt
 Total Current Liabilities 61.3 M
 Net Debt
 Total Debt 4.9 M
 Total Liabilities 67.8 M
EQUITY
 Total Equity 714.6 M
 Retained Earnings -1.97 B
VALUATION & PER-SHARE METRICS EQUITY & PER-SHARE METRICS
 Book Value Per-Share 9.10
 Shares Outstanding 78.500 M
 Revenue Per-Share 0.00
VALUATION
 Market Capitalization 2.7 B
 Enterprise Value 2.0 B
 Enterprise Multiple -25.368
Enterprise Multiple QoQ 32.173 %
Enterprise Multiple YoY 92.01 %
Enterprise Multiple IPRWA high: 148.972
median: 38.141
mean: 19.969
CLDX: -25.368
low: -178.99
 EV/R 91924.543
CAPITAL STRUCTURE
 Asset To Equity 1.095
 Asset To Liability 11.542
 Debt To Capital 0.007
 Debt To Assets 0.006
Debt To Assets QoQ 68.097 %
Debt To Assets YoY 43.151 %
Debt To Assets IPRWA high: 0.833
mean: 0.281
median: 0.223
CLDX: 0.006
low: 0.0
 Debt To Equity 0.007
Debt To Equity QoQ 64.115 %
Debt To Equity YoY 48.485 %
Debt To Equity IPRWA high: 1.719
mean: 0.308
median: 0.098
CLDX: 0.007
low: -0.777
PRICE-BASED VALUATION
 Price To Book (P/B) 3.828
Price To Book QoQ -14.972 %
Price To Book YoY 71.888 %
Price To Book IPRWA high: 18.326
mean: 8.396
median: 6.334
CLDX: 3.828
low: -9.25
 Price To Earnings (P/E) -37.065
Price To Earnings QoQ 41.768 %
Price To Earnings YoY 46.636 %
Price To Earnings IPRWA high: 160.554
median: 40.973
mean: 20.697
CLDX: -37.065
low: -176.575
 PE/G Ratio 1.822
 Price To Sales (P/S) 124319.225
Price To Sales QoQ -9.199 %
Price To Sales YoY 6118.384 %
Price To Sales IPRWA CLDX: 124319.225
high: 559.892
mean: 54.657
median: 20.828
low: 0.983
FORWARD MULTIPLES
Forward P/E -30.221
Forward PE/G 1.486
Forward P/S 445951.893
EFFICIENCY OPERATIONAL
 Operating Leverage -0.097
ASSET & SALES
 Asset Turnover Ratio 0.0
Asset Turnover Ratio QoQ
Asset Turnover Ratio YoY -100.0 %
Asset Turnover Ratio IPRWA high: 0.511
mean: 0.116
median: 0.106
low: 0.0
CLDX: 0.0
 Receivables Turnover 0.096
Receivables Turnover Ratio QoQ 615.943 %
Receivables Turnover Ratio YoY -92.44 %
Receivables Turnover Ratio IPRWA high: 4.472
median: 1.538
mean: 1.448
CLDX: 0.096
low: 0.058
 Inventory Turnover
Inventory Turnover Ratio QoQ
Inventory Turnover Ratio YoY
Inventory Turnover Ratio IPRWA
 Days Sales Outstanding (DSO) 953.977
CASH CYCLE
 Cash Conversion Cycle Days (CCC) 953.977
Cash Conversion Cycle Days QoQ -86.03 %
Cash Conversion Cycle Days YoY
Cash Conversion Cycle Days IPRWA high: 1415.294
CLDX: 953.977
median: 197.717
mean: 177.016
low: -771.823
CAPITAL DEPLOYMENT
 Cash Conversion Ratio 0.0
 CapEx To Revenue -144.5
 CapEx To Depreciation -3.524
 
CAPITAL, LIQUIDITY & COVERAGE CAPITAL STRUCTURE
 Total Capital 714.6 M
 Net Invested Capital 714.6 M
 Invested Capital 714.6 M
 Net Tangible Assets 687.4 M
 Net Working Capital 663.6 M
LIQUIDITY
 Cash Ratio 11.701
 Current Ratio 11.821
Current Ratio QoQ 32.497 %
Current Ratio YoY -39.905 %
Current Ratio IPRWA high: 31.351
CLDX: 11.821
mean: 4.785
median: 3.163
low: 0.34
 Quick Ratio
Quick Ratio QoQ
Quick Ratio YoY
Quick Ratio IPRWA
COVERAGE & LEVERAGE
 Debt To EBITDA -0.062
 Cost Of Debt 91.309 %
 Interest Coverage Ratio -25.924
Interest Coverage Ratio QoQ -4.515 %
Interest Coverage Ratio YoY 26.256 %
Interest Coverage Ratio IPRWA high: 533.0
mean: 42.332
median: 2.609
CLDX: -25.924
low: -1501.103
 Operating Cash Flow Ratio -1.113
TIMING / LIQUIDITY
 Days Payables Outstanding (DPO)
DIVIDENDS
 Dividend Coverage Ratio
 Dividend Payout Ratio
 Dividend Rate
 Dividend Yield
PERFORMANCE GROWTH
 Asset Growth Rate 53.026 %
 Revenue Growth 46.667 %
Revenue Growth QoQ -153.271 %
Revenue Growth YoY 826.668 %
Revenue Growth IPRWA high: 278.717 %
CLDX: 46.667 %
mean: 15.266 %
median: 11.617 %
low: -242.388 %
 Earnings Growth -20.339 %
Earnings Growth QoQ 520.281 %
Earnings Growth YoY -511.887 %
Earnings Growth IPRWA high: 185.714 %
median: 13.636 %
mean: 10.829 %
CLDX: -20.339 %
low: -220.0 %
MARGINS
 Gross Margin
Gross Margin QoQ
Gross Margin YoY
Gross Margin IPRWA
 EBIT Margin -366468.182 %
EBIT Margin QoQ -34.896 %
EBIT Margin YoY 4089.388 %
EBIT Margin IPRWA high: 103.704 %
median: 22.839 %
mean: -92.727 %
low: -3750.867 %
CLDX: -366468.182 %
 Return On Sales (ROS) -366468.182 %
Return On Sales QoQ -34.896 %
Return On Sales YoY 4089.388 %
Return On Sales IPRWA high: 74.372 %
median: 30.748 %
mean: -75.426 %
low: -3837.989 %
CLDX: -366468.182 %
CASH FLOW
 Free Cash Flow (FCF) -60.59 M
 Free Cash Flow Yield -2.215 %
Free Cash Flow Yield QoQ -32.325 %
Free Cash Flow Yield YoY -27.732 %
Free Cash Flow Yield IPRWA high: 13.067 %
median: 0.852 %
mean: 0.551 %
CLDX: -2.215 %
low: -26.527 %
 Free Cash Growth -9.874 %
Free Cash Growth QoQ -421.001 %
Free Cash Growth YoY -45.529 %
Free Cash Growth IPRWA high: 175.34 %
mean: 20.343 %
median: 1.424 %
CLDX: -9.874 %
low: -249.171 %
 Free Cash To Net Income 0.824
 Cash Flow Margin -310386.364 %
 Cash Flow To Earnings 0.929
VALUE & RETURNS
 Economic Value Added
 Return On Assets (ROA) -11.364 %
Return On Assets QoQ -20.985 %
Return On Assets YoY 43.739 %
Return On Assets IPRWA high: 20.575 %
median: 0.317 %
mean: -4.01 %
CLDX: -11.364 %
low: -44.847 %
 Return On Capital Employed (ROCE) -11.182 %
 Return On Equity (ROE) -0.103
Return On Equity QoQ -40.361 %
Return On Equity YoY 19.106 %
Return On Equity IPRWA high: 0.462
median: 0.006
CLDX: -0.103
mean: -0.103
low: -0.887
 DuPont ROE 0.0 %
 Return On Invested Capital (ROIC)
Return On Invested Capital QoQ
Return On Invested Capital YoY
Return On Invested Capital IPRWA

Six-Week Outlook

Event cadence and technicals point to elevated volatility. The company reiterated Phase 3 chronic spontaneous urticaria topline timing in the corporate update, concentrating attention into the September–October 2026 window; technical indicators show weakening momentum and MRO‑suggested downside pressure that could produce swift directional moves around those readouts. Traders should expect heightened intraday swings as study readouts and related conference presentations populate the calendar, with liquidity and short-term moving‑average levels likely to act as focal support and resistance.

About Celldex Therapeutics, Inc.

Celldex Therapeutics, Inc. (NASDAQ:CLDX) develops advanced antibody-based therapeutics aimed at treating inflammatory, allergic, autoimmune, and other severe diseases. The company focuses on creating innovative monoclonal and bispecific antibodies, with a notable emphasis on CDX-0159, a Phase II monoclonal antibody targeting the receptor tyrosine kinase KIT. This therapeutic candidate holds potential for addressing challenging medical conditions. Founded in 1983, Celldex maintains its headquarters in Hampton, New Jersey. The company leverages cutting-edge scientific research to address unmet medical needs, collaborating with renowned institutions such as Yale University. These partnerships enhance Celldex’s research capabilities and expedite the development of its therapeutic candidates. Celldex Therapeutics actively contributes to the biopharmaceutical industry through strategic partnerships and a strong research framework. The company remains dedicated to improving patient outcomes and quality of life worldwide by developing transformative treatments.



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