Celldex Therapeutics, Inc (NASDAQ:CLDX) Clinical Data Recalibrates Near‑Term Growth Trajectory

Recent trial readouts and presentation timing shift the stock’s short‑term technical bias despite ample liquidity; fundamentals still show a high valuation relative to underlying revenue and profitability. Market reaction will hinge on upcoming Phase 3 readouts and how the broader program portfolio performs versus expectations.

Recent News

Jun 14, 2026 — Celldex presented EAACI data showing positive Phase 1 results for CDX‑622 and long‑term Phase 2 barzolvolimab results that reported durable off‑treatment benefit in chronic spontaneous urticaria (CSU), with Phase 3 topline expected in Q4 2026 noted previously. Jul 15, 2026 — the CFO notified the company of plans to retire effective ~Mar 31, 2027. Jul 21, 2026 — topline Phase 2 results in prurigo nodularis did not meet primary or key secondary endpoints and the PN program will be discontinued; Phase 3 CSU topline timing referenced for Sept/Oct 2026 in the release.

Technical Analysis

Directional indicators (ADX/DI+/DI-): ADX at 27.93 signals a strong trend strength. DI+ stands at 27.93 and shows an increasing trend, indicating bullish directional pressure; DI- at 15.48 is decreasing, reinforcing the same bullish directional read.

MACD: MACD sits at 1.31 and is increasing while the MACD signal line reads 0.93, so MACD currently trades above its signal line — a bullish momentum signal that supports near‑term upside bias.

MRO (Momentum/Regression Oscillator): MRO at 34.66 shows a dip & reversal pattern. Because MRO remains positive, price currently trades above WMDST’s target and the indicator implies potential mean reversion pressure even as the dip & reversal suggests recent momentum recovery.

RSI: RSI at 61.56 with an increasing trend indicates strengthening momentum below traditional overbought thresholds, leaving room for further advance before momentum exhaustion.

Price vs moving averages and bands: Last close $41.71 trades above the 20‑day ($37.68), 50‑day ($35.04) and 200‑day ($29.98) averages; the 12‑day EMA (38.91) is increasing. Price sits above the Bollinger 1x upper band ($40.41), suggesting short‑term strength but a stretched intraday position relative to the 20‑day volatility band. SuperTrend lower support sits near $38.51.

Volume and volatility context: Daily volume (808,900) runs below the 10‑, 50‑ and 200‑day averages, implying current moves lack above‑average participation. 42‑day volatility 3% and 52‑week volatility 4% reflect low realized volatility versus many peers; 42‑day beta 0.31 versus 52‑week beta 1.44 shows a recent reduction in sensitivity to the market.

 


Fundamental Analysis

Profitability and cash flows: Total revenue $15,000 versus R&D expense $73.0M highlights development‑stage economics. EBIT -$84.435M and EBITDA -$83.581M produce an EBIT margin of -5,629.0%. QoQ, EBIT margin improved by 6.82%; YoY improvement shows 61.36% relative change. Operating cash flow -$65.588M and free cash flow -$67.227M reflect ongoing negative operating cash generation; free cash flow to net income equals 85.44%.

Earnings per share: GAAP EPS actual -$0.94 versus estimate -$1.05, an absolute beat of $0.11 and an EPS surprise of +10.48% versus consensus. Forward EPS -$1.0469 and forward PE remains negative at -24.57x, consistent with ongoing losses.

Liquidity and leverage: Cash and short‑term investments $451.46M with cash $35.73M and net working capital $407.75M. Current ratio 8.92x and cash ratio 8.77x denote ample near‑term liquidity. Total debt $1.91M produces debt to assets of 0.37% and debt to equity 0.418% — effectively minimal leverage.

Valuation multiples and peer context: Market capitalization $2.054B against enterprise value $1.604B yields extreme revenue multiples driven by very low reported revenue. Price‑to‑book 4.50 is below the industry peer mean of 7.50 and below the industry peer median of 5.88. PEG and PE metrics remain negative or elevated where applicable; price‑to‑sales and forward PS metrics register exceptionally large values due to near‑zero revenue base. WMDST notes the current valuation as over‑valued given market cap and multiples relative to operating scale and revenue.

Growth and returns: Reported revenue growth QoQ +5.01% and revenue growth YoY +114.45% (absolute percent representation). Return on equity -17.25% and return on assets -14.38% indicate negative returns consistent with development‑stage losses.

MOST-RECENT QUARTERLY REPORT
REPORT PERIOD ENDING: 2026-03-31
REPORT DATE: 2026-08-06
NEXT REPORT DATE: 2026-11-05
CASH FLOW  Begin Period Cash Flow 28.9 M
 Operating Cash Flow -65.59 M
 Capital Expenditures -1.64 M
 Change In Working Capital 4.3 M
 Dividends Paid
 Cash Flow Delta 6.9 M
 End Period Cash Flow 35.7 M
 
INCOME STATEMENT REVENUE
 Total Revenue 15.0 K
 Forward Revenue 3.3 K
COSTS
 Cost Of Revenue
 Depreciation 854.0 K
 Depreciation and Amortization 854.0 K
 Research and Development 73.0 M
 Total Operating Expenses 84.5 M
PROFITABILITY
 Gross Profit
 EBITDA -83.58 M
 EBIT -84.44 M
 Operating Income -84.44 M
 Interest Income
 Interest Expense
 Net Interest Income
 Income Before Tax -78.69 M
 Tax Provision
 Tax Rate
 Net Income -78.69 M
 Net Income From Continuing Operations -78.69 M
EARNINGS
 EPS Estimate -1.05
 EPS Actual -0.94
 EPS Difference 0.11
 EPS Surprise 10.476 %
 Forward EPS -1.05
 
BALANCE SHEET ASSETS
 Total Assets 511.3 M
 Intangible Assets 27.2 M
 Net Tangible Assets 429.0 M
 Total Current Assets 459.2 M
 Cash and Short-Term Investments 451.5 M
 Cash 35.7 M
 Net Receivables 230.0 K
 Inventory
 Long-Term Investments 634.0 K
LIABILITIES
 Accounts Payable 10.4 M
 Short-Term Debt
 Total Current Liabilities 51.5 M
 Net Debt
 Total Debt 1.9 M
 Total Liabilities 55.0 M
EQUITY
 Total Equity 456.2 M
 Retained Earnings -1.89 B
VALUATION & PER-SHARE METRICS EQUITY & PER-SHARE METRICS
 Book Value Per-Share 6.85
 Shares Outstanding 66.569 M
 Revenue Per-Share 0.00
VALUATION
 Market Capitalization 2.1 B
 Enterprise Value 1.6 B
 Enterprise Multiple -19.193
Enterprise Multiple QoQ 42.922 %
Enterprise Multiple YoY 75.093 %
Enterprise Multiple IPRWA high: 75.51
median: 50.282
mean: 15.237
CLDX: -19.193
low: -128.217
 EV/R 106943.468
CAPITAL STRUCTURE
 Asset To Equity 1.121
 Asset To Liability 9.291
 Debt To Capital 0.004
 Debt To Assets 0.004
Debt To Assets QoQ -6.983 %
Debt To Assets YoY -19.612 %
Debt To Assets IPRWA high: 1.112
mean: 0.187
median: 0.066
CLDX: 0.004
low: 0.0
 Debt To Equity 0.004
Debt To Equity QoQ -5.643 %
Debt To Equity YoY -14.344 %
Debt To Equity IPRWA high: 1.864
mean: 0.268
median: 0.051
CLDX: 0.004
low: -1.172
PRICE-BASED VALUATION
 Price To Book (P/B) 4.502
Price To Book QoQ 41.619 %
Price To Book YoY 134.74 %
Price To Book IPRWA high: 20.844
mean: 7.497
median: 5.877
CLDX: 4.502
low: -11.267
 Price To Earnings (P/E) -26.145
Price To Earnings QoQ 26.679 %
Price To Earnings YoY 4.285 %
Price To Earnings IPRWA high: 74.242
median: 50.465
mean: 11.617
CLDX: -26.145
low: -125.804
 PE/G Ratio 7.973
 Price To Sales (P/S) 136913.468
Price To Sales QoQ 888.665 %
Price To Sales YoY 6958.601 %
Price To Sales IPRWA CLDX: 136913.468
high: 802.301
mean: 58.294
median: 24.412
low: 0.192
FORWARD MULTIPLES
Forward P/E -24.566
Forward PE/G 7.492
Forward P/S 569365.682
EFFICIENCY OPERATIONAL
 Operating Leverage 0.036
ASSET & SALES
 Asset Turnover Ratio 0.0
Asset Turnover Ratio QoQ -100.0 %
Asset Turnover Ratio YoY -100.0 %
Asset Turnover Ratio IPRWA high: 0.403
mean: 0.105
median: 0.094
low: 0.0
CLDX: 0.0
 Receivables Turnover 0.013
Receivables Turnover Ratio QoQ -88.379 %
Receivables Turnover Ratio YoY -98.305 %
Receivables Turnover Ratio IPRWA high: 6.586
median: 1.405
mean: 1.299
low: 0.065
CLDX: 0.013
 Inventory Turnover
Inventory Turnover Ratio QoQ
Inventory Turnover Ratio YoY
Inventory Turnover Ratio IPRWA
 Days Sales Outstanding (DSO) 6828.542
CASH CYCLE
 Cash Conversion Cycle Days (CCC) 6828.542
Cash Conversion Cycle Days QoQ 760.317 %
Cash Conversion Cycle Days YoY 5796.731 %
Cash Conversion Cycle Days IPRWA CLDX: 6828.542
high: 1575.417
mean: 212.055
median: 208.031
low: -1586.264
CAPITAL DEPLOYMENT
 Cash Conversion Ratio 0.0
 CapEx To Revenue -109.267
 CapEx To Depreciation -1.919
 
CAPITAL, LIQUIDITY & COVERAGE CAPITAL STRUCTURE
 Total Capital 456.2 M
 Net Invested Capital 456.2 M
 Invested Capital 456.2 M
 Net Tangible Assets 429.0 M
 Net Working Capital 407.8 M
LIQUIDITY
 Cash Ratio 8.771
 Current Ratio 8.922
Current Ratio QoQ -14.913 %
Current Ratio YoY -58.825 %
Current Ratio IPRWA high: 32.587
CLDX: 8.922
mean: 3.776
median: 1.967
low: 0.016
 Quick Ratio
Quick Ratio QoQ
Quick Ratio YoY
Quick Ratio IPRWA
COVERAGE & LEVERAGE
 Debt To EBITDA -0.023
 Cost Of Debt 146.56 %
 Interest Coverage Ratio -27.15
Interest Coverage Ratio QoQ -3.119 %
Interest Coverage Ratio YoY 34.581 %
Interest Coverage Ratio IPRWA high: 604.866
median: -7.668
CLDX: -27.15
mean: -70.207
low: -1789.522
 Operating Cash Flow Ratio -1.299
TIMING / LIQUIDITY
 Days Payables Outstanding (DPO)
DIVIDENDS
 Dividend Coverage Ratio
 Dividend Payout Ratio
 Dividend Rate
 Dividend Yield
PERFORMANCE GROWTH
 Asset Growth Rate -12.304 %
 Revenue Growth -87.603 %
Revenue Growth QoQ 5.008 %
Revenue Growth YoY 114.445 %
Revenue Growth IPRWA high: 269.985 %
mean: -10.273 %
median: -12.166 %
CLDX: -87.603 %
low: -242.388 %
 Earnings Growth -3.279 %
Earnings Growth QoQ -115.77 %
Earnings Growth YoY -123.28 %
Earnings Growth IPRWA high: 215.789 %
CLDX: -3.279 %
median: -3.659 %
mean: -10.413 %
low: -250.0 %
MARGINS
 Gross Margin
Gross Margin QoQ
Gross Margin YoY
Gross Margin IPRWA
 EBIT Margin -562900.0 %
EBIT Margin QoQ 681.51 %
EBIT Margin YoY 6135.603 %
EBIT Margin IPRWA high: 2524.194 %
median: 31.724 %
mean: -90.676 %
low: -7259.515 %
CLDX: -562900.0 %
 Return On Sales (ROS) -562900.0 %
Return On Sales QoQ 681.51 %
Return On Sales YoY 6135.603 %
Return On Sales IPRWA high: 100.302 %
median: 30.354 %
mean: -90.96 %
low: -7394.476 %
CLDX: -562900.0 %
CASH FLOW
 Free Cash Flow (FCF) -67.23 M
 Free Cash Flow Yield -3.273 %
Free Cash Flow Yield QoQ -15.904 %
Free Cash Flow Yield YoY -19.245 %
Free Cash Flow Yield IPRWA high: 11.709 %
median: 0.78 %
mean: -0.277 %
CLDX: -3.273 %
low: -49.776 %
 Free Cash Growth 3.076 %
Free Cash Growth QoQ -90.656 %
Free Cash Growth YoY -95.224 %
Free Cash Growth IPRWA high: 253.163 %
CLDX: 3.076 %
mean: 1.815 %
median: -19.248 %
low: -249.577 %
 Free Cash To Net Income 0.854
 Cash Flow Margin -445780.0 %
 Cash Flow To Earnings 0.85
VALUE & RETURNS
 Economic Value Added
 Return On Assets (ROA) -14.382 %
Return On Assets QoQ 8.897 %
Return On Assets YoY 104.755 %
Return On Assets IPRWA high: 38.074 %
median: -6.451 %
mean: -12.306 %
CLDX: -14.382 %
low: -67.817 %
 Return On Capital Employed (ROCE) -18.364 %
 Return On Equity (ROE) -0.172
Return On Equity QoQ 11.812 %
Return On Equity YoY 125.363 %
Return On Equity IPRWA high: 0.797
median: -0.073
CLDX: -0.172
mean: -0.308
low: -1.265
 DuPont ROE 0.0 %
 Return On Invested Capital (ROIC)
Return On Invested Capital QoQ
Return On Invested Capital YoY
Return On Invested Capital IPRWA

Six-Week Outlook

Technical setup favors continuation of the recent rally: multiple momentum indicators (MACD > signal, rising RSI, price above key moving averages) point to further upside potential, while MRO’s positive reading cautions that price sits above WMDST’s target and could undergo mean reversion if follow‑through buying fails. Low relative volume weakens the conviction of any breakout above the 1x Bollinger upper band; the nearest structural support cluster aligns with the 20‑day average and SuperTrend lower near $38.50.

Fundamental and news flow drivers to watch over the next six weeks include management transitions tied to the CFO retirement timeline and any commentary or interim analyses related to the Phase 3 CSU program timing (company disclosure referenced Sept/Oct 2026 timing). The July PN topline failure reduces optionality for that indication and concentrates program risk around CSU and other ongoing trials; upcoming communications from the company may prompt volatility as the market re‑prices program probabilities.

WMDST valuation stance: given high multiples driven by minimal revenue, persistent negative margins and the mixed clinical readouts, the current valuation remains classified as over‑valued. Technical momentum can produce near‑term price appreciation, but the fundamental profile and trial outcomes will determine sustainability beyond the immediate trading window.

About Celldex Therapeutics, Inc.

Celldex Therapeutics, Inc. (NASDAQ:CLDX) develops advanced antibody-based therapeutics aimed at treating inflammatory, allergic, autoimmune, and other severe diseases. The company focuses on creating innovative monoclonal and bispecific antibodies, with a notable emphasis on CDX-0159, a Phase II monoclonal antibody targeting the receptor tyrosine kinase KIT. This therapeutic candidate holds potential for addressing challenging medical conditions. Founded in 1983, Celldex maintains its headquarters in Hampton, New Jersey. The company leverages cutting-edge scientific research to address unmet medical needs, collaborating with renowned institutions such as Yale University. These partnerships enhance Celldex’s research capabilities and expedite the development of its therapeutic candidates. Celldex Therapeutics actively contributes to the biopharmaceutical industry through strategic partnerships and a strong research framework. The company remains dedicated to improving patient outcomes and quality of life worldwide by developing transformative treatments.



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