IDEAYA Biosciences, Inc (NASDAQ:IDYA) Accelerates Clinical Momentum; Near-Term Data Catalysts Point To Repricing

Strong liquidity and multiple clinical readouts position the company for renewed fundamental focus, while mixed technical signals suggest short-term volatility around near-term catalysts.

Recent News

On April 13th IDEAYA announced positive topline results from the Phase 2/3 OptimUM-02 trial of darovasertib in metastatic uveal melanoma; the company scheduled a detailed presentation and follow-up at major medical meetings. On April 6th IDEAYA reported first‑patient‑in for the Phase 1 dose‑escalation trial of IDE574, a KAT6/7 dual inhibitor for multiple solid tumors. On April 21st IDEAYA announced a late‑breaking oral presentation at ASCO 2026 to provide complete OptimUM‑02 data, and the company confirmed participation in investor conferences through late May.

Technical Analysis

ADX / DI+/DI-: ADX at 31.62 signals a strong trend environment; DI+ shows a peak & reversal while DI- shows a dip & reversal, both directional indicators read as bearish pressure despite trend strength, implying directional conflict around current price levels.

MACD: MACD at 1.72 with an increasing trend and the MACD line above the 0.97 signal line indicates bullish momentum and a buy-side tilt in short-term momentum.

MRO: MRO at 26.72 (positive) indicates price sits above the model target and, per the oscillator interpretation, a higher probability of a corrective move toward the target despite rising momentum.

RSI: RSI 56.2 and increasing shows momentum remains constructive but not overbought, supporting the possibility of additional short-term upside before a corrective pullback.

Price vs Moving Averages & Bands: Last close $37.27 trades above the 12‑day EMA ($34.31), 20‑day average ($32.93) and 200‑day average ($31.60), supporting a near‑term bullish bias; price sits just above the 1× upper Bollinger band ($36.78), suggesting short‑term stretch toward the upper volatility band with superTrend support near $33.19.

Volume & Volatility: Intraday volume (~1.59M) sits slightly below the 10‑day average (~1.70M) but above the 200‑day average (~1.11M); 42‑day and 52‑week volatility remain low (~3%), implying any directional move tied to clinical news may produce outsized price reaction relative to recent baseline volatility.

 


Fundamental Analysis

Profitability & Operations: Operating income stood at -$108,544,000 with an operating (EBIT) margin of -16.55%, reflecting continued investment ahead of commercialization; EBIT margin improved QoQ by +90.29% but remains negative year‑over‑year. Research and development expense totaled $95,726,000, driving the operating loss relative to revenue of $6,560,000.

Liquidity & Capital Structure: Cash and short‑term investments total $671,201,000 with cash of $157,522,000 and a cash ratio of 10.35 and current ratio of 10.74, indicating ample near‑term runway; total debt equals $28,600,000, keeping debt‑to‑assets low at 2.78% and debt‑to‑equity at 3.05%.

Growth & Returns: Reported revenue $6,560,000 produced YoY revenue growth of -94.77%; return on equity -10.51% and return on assets -9.21% remain negative but showed QoQ improvements (ROE QoQ +29.14%, ROA QoQ +26.89%).

Per‑share & Valuation Metrics: EPS actual -$1.11 versus estimate -$0.98 produced an EPS surprise of -13.27%. Price‑to‑book 2.98, price‑to‑sales 426.44, and enterprise value to revenue (EVR) 328.48 reflect valuation anchored to future pipeline potential; P/E and forward P/E remain negative (current P/E -28.69; forward P/E -39.44) given ongoing losses.

Peer Comparisons (where provided): The company’s EBIT margin of -16.55% sits below the industry peer mean of -1.10% and industry peer median of 0.23%; the current ratio of 10.74 exceeds the industry peer mean of 3.94; price‑to‑book at 2.98 falls below the industry peer mean of 7.56. These comparisons highlight relative strengths in liquidity and lower P/B versus the peer mean while profitability remains weaker than the industry peer mean and median.

Valuation Conclusion: The current valuation as determined by WMDST classifies the stock as under‑valued, supported by a large cash position and multiple clinical assets advancing through registrational or early development stages; negative operating margins, steep YoY revenue decline and persistent losses continue to weigh on traditional earnings multiples.

MOST-RECENT QUARTERLY REPORT
REPORT PERIOD ENDING: 2026-03-31
REPORT DATE: 2026-05-05
NEXT REPORT DATE: 2026-08-04
CASH FLOW  Begin Period Cash Flow 113.8 M
 Operating Cash Flow -75.17 M
 Capital Expenditures -967.00 K
 Change In Working Capital 8.9 M
 Dividends Paid
 Cash Flow Delta 45.0 M
 End Period Cash Flow 158.8 M
 
INCOME STATEMENT REVENUE
 Total Revenue 6.6 M
 Forward Revenue 1.3 M
COSTS
 Cost Of Revenue
 Depreciation 1.1 M
 Depreciation and Amortization 1.1 M
 Research and Development 95.7 M
 Total Operating Expenses 115.1 M
PROFITABILITY
 Gross Profit
 EBITDA -107.40 M
 EBIT -108.54 M
 Operating Income -108.54 M
 Interest Income 10.0 M
 Interest Expense
 Net Interest Income 10.0 M
 Income Before Tax -98.54 M
 Tax Provision
 Tax Rate
 Net Income -98.54 M
 Net Income From Continuing Operations -98.54 M
EARNINGS
 EPS Estimate -0.98
 EPS Actual -1.11
 EPS Difference -0.13
 EPS Surprise -13.265 %
 Forward EPS -0.91
 
BALANCE SHEET ASSETS
 Total Assets 1.0 B
 Intangible Assets
 Net Tangible Assets 937.3 M
 Total Current Assets 696.1 M
 Cash and Short-Term Investments 671.2 M
 Cash 157.5 M
 Net Receivables
 Inventory
 Long-Term Investments 1.3 M
LIABILITIES
 Accounts Payable 20.7 M
 Short-Term Debt
 Total Current Liabilities 64.8 M
 Net Debt
 Total Debt 28.6 M
 Total Liabilities 93.1 M
EQUITY
 Total Equity 937.3 M
 Retained Earnings -835.08 M
VALUATION & PER-SHARE METRICS EQUITY & PER-SHARE METRICS
 Book Value Per-Share 10.67
 Shares Outstanding 87.856 M
 Revenue Per-Share 0.07
VALUATION
 Market Capitalization 2.8 B
 Enterprise Value 2.2 B
 Enterprise Multiple -20.064
Enterprise Multiple QoQ -18.789 %
Enterprise Multiple YoY 59.939 %
Enterprise Multiple IPRWA high: 75.51
median: 27.492
mean: 7.274
IDYA: -20.064
low: -128.217
 EV/R 328.482
CAPITAL STRUCTURE
 Asset To Equity 1.099
 Asset To Liability 11.069
 Debt To Capital 0.03
 Debt To Assets 0.028
Debt To Assets QoQ 10.334 %
Debt To Assets YoY 17.677 %
Debt To Assets IPRWA high: 1.112
mean: 0.168
median: 0.032
IDYA: 0.028
low: 0.0
 Debt To Equity 0.031
Debt To Equity QoQ 11.799 %
Debt To Equity YoY 20.308 %
Debt To Equity IPRWA high: 1.864
mean: 0.194
median: 0.051
IDYA: 0.031
low: -1.172
PRICE-BASED VALUATION
 Price To Book (P/B) 2.985
Price To Book QoQ 4.621 %
Price To Book YoY 78.657 %
Price To Book IPRWA high: 20.93
mean: 7.561
median: 5.613
IDYA: 2.985
low: -11.267
 Price To Earnings (P/E) -28.686
Price To Earnings QoQ -18.877 %
Price To Earnings YoY 20.386 %
Price To Earnings IPRWA high: 74.242
mean: -2.197
median: -14.301
IDYA: -28.686
low: -125.804
 PE/G Ratio -1.586
 Price To Sales (P/S) 426.44
Price To Sales QoQ 58.927 %
Price To Sales YoY
Price To Sales IPRWA high: 864.732
IDYA: 426.44
mean: 63.484
median: 29.52
low: 0.192
FORWARD MULTIPLES
Forward P/E -39.445
Forward PE/G -2.181
Forward P/S 2067.912
EFFICIENCY OPERATIONAL
 Operating Leverage -0.372
ASSET & SALES
 Asset Turnover Ratio 0.006
Asset Turnover Ratio QoQ -35.338 %
Asset Turnover Ratio YoY
Asset Turnover Ratio IPRWA high: 0.403
mean: 0.103
median: 0.094
IDYA: 0.006
low: 0.0
 Receivables Turnover
Receivables Turnover Ratio QoQ
Receivables Turnover Ratio YoY
Receivables Turnover Ratio IPRWA
 Inventory Turnover
Inventory Turnover Ratio QoQ
Inventory Turnover Ratio YoY
Inventory Turnover Ratio IPRWA
 Days Sales Outstanding (DSO)
CASH CYCLE
 Cash Conversion Cycle Days (CCC)
Cash Conversion Cycle Days QoQ
Cash Conversion Cycle Days YoY
Cash Conversion Cycle Days IPRWA high: 930.567
median: 373.655
mean: 219.314
IDYA: 0
low: -833.016
CAPITAL DEPLOYMENT
 Cash Conversion Ratio 0.01
 CapEx To Revenue -0.147
 CapEx To Depreciation -0.846
 
CAPITAL, LIQUIDITY & COVERAGE CAPITAL STRUCTURE
 Total Capital 937.3 M
 Net Invested Capital 937.3 M
 Invested Capital 937.3 M
 Net Tangible Assets 937.3 M
 Net Working Capital 631.3 M
LIQUIDITY
 Cash Ratio 10.353
 Current Ratio 10.737
Current Ratio QoQ -5.282 %
Current Ratio YoY -22.875 %
Current Ratio IPRWA high: 32.587
IDYA: 10.737
mean: 3.937
median: 2.409
low: 0.016
 Quick Ratio
Quick Ratio QoQ
Quick Ratio YoY
Quick Ratio IPRWA
COVERAGE & LEVERAGE
 Debt To EBITDA -0.266
 Cost Of Debt 71.803 %
 Interest Coverage Ratio -4.33
Interest Coverage Ratio QoQ 14.776 %
Interest Coverage Ratio YoY 28.623 %
Interest Coverage Ratio IPRWA high: 604.866
IDYA: -4.33
median: -14.877
mean: -78.107
low: -1789.522
 Operating Cash Flow Ratio -1.454
TIMING / LIQUIDITY
 Days Payables Outstanding (DPO)
DIVIDENDS
 Dividend Coverage Ratio
 Dividend Payout Ratio
 Dividend Rate
 Dividend Yield
PERFORMANCE GROWTH
 Asset Growth Rate -7.119 %
 Revenue Growth -94.767 %
Revenue Growth QoQ -0.0 %
Revenue Growth YoY
Revenue Growth IPRWA high: 242.212 %
median: -7.18 %
mean: -9.919 %
IDYA: -94.767 %
low: -242.388 %
 Earnings Growth 18.085 %
Earnings Growth QoQ -110.596 %
Earnings Growth YoY -140.219 %
Earnings Growth IPRWA high: 215.789 %
IDYA: 18.085 %
median: -5.682 %
mean: -13.644 %
low: -250.0 %
MARGINS
 Gross Margin
Gross Margin QoQ
Gross Margin YoY
Gross Margin IPRWA
 EBIT Margin -1654.634 %
EBIT Margin QoQ 90.291 %
EBIT Margin YoY
EBIT Margin IPRWA high: 2524.194 %
median: 23.412 %
mean: -109.709 %
IDYA: -1654.634 %
low: -7259.515 %
 Return On Sales (ROS) -1654.634 %
Return On Sales QoQ 90.291 %
Return On Sales YoY
Return On Sales IPRWA high: 100.302 %
median: 20.658 %
mean: -109.71 %
IDYA: -1654.634 %
low: -7394.476 %
CASH FLOW
 Free Cash Flow (FCF) -76.14 M
 Free Cash Flow Yield -2.722 %
Free Cash Flow Yield QoQ -12.532 %
Free Cash Flow Yield YoY -24.494 %
Free Cash Flow Yield IPRWA high: 11.709 %
median: 0.11 %
mean: -0.511 %
IDYA: -2.722 %
low: -45.34 %
 Free Cash Growth -16.175 %
Free Cash Growth QoQ -90.13 %
Free Cash Growth YoY -67.495 %
Free Cash Growth IPRWA high: 253.163 %
mean: 4.314 %
IDYA: -16.175 %
median: -16.303 %
low: -249.577 %
 Free Cash To Net Income 0.773
 Cash Flow Margin -1436.646 %
 Cash Flow To Earnings 0.956
VALUE & RETURNS
 Economic Value Added
 Return On Assets (ROA) -9.211 %
Return On Assets QoQ 26.891 %
Return On Assets YoY 43.496 %
Return On Assets IPRWA high: 38.074 %
median: -8.157 %
IDYA: -9.211 %
mean: -13.764 %
low: -67.817 %
 Return On Capital Employed (ROCE) -11.242 %
 Return On Equity (ROE) -0.105
Return On Equity QoQ 29.136 %
Return On Equity YoY 50.789 %
Return On Equity IPRWA high: 0.797
IDYA: -0.105
median: -0.115
mean: -0.344
low: -1.265
 DuPont ROE -10.051 %
 Return On Invested Capital (ROIC)
Return On Invested Capital QoQ
Return On Invested Capital YoY
Return On Invested Capital IPRWA

Six-Week Outlook

Clinical readouts and conference presentations through early summer create a catalyst window likely to drive episodic volatility. Technical momentum (MACD above signal, price above key moving averages) supports near‑term upside attempts, while directional indicators and a positive MRO signal the risk of mean reversion. Expect trading to remain range‑bound to directional around clinical updates; liquidity metrics reduce capital‑risk pressure but fundamental news flow will likely dictate directional bias over the next six weeks.

About IDEAYA Biosciences, Inc.

Ideaya Biosciences, Inc. (NASDAQ:IDYA) develops precision medicine solutions in oncology, with a particular emphasis on synthetic lethality, an innovative approach in cancer therapy. Based in South San Francisco, California, the company targets genetically defined patient populations through its pipeline of therapeutic candidates. Notable among these are IDE196, a Phase 2/3 protein kinase C inhibitor for cancers with GNAQ or GNA11 mutations, and IDE397, a Phase 1/2 inhibitor addressing solid tumors with specific gene deletions. Ideaya collaborates with industry leaders such as GlaxoSmithKline, Pfizer, and Novartis, which enhances its drug discovery and development capabilities. The company employs advanced technologies, including the DECIPHER dual CRISPR library and INQUIRE chemical library, to identify new therapeutic targets and biomarkers. Ideaya’s approach to cancer treatment involves not only drug development but also a deep understanding of the genetic and molecular mechanisms of cancer. This strategy aims to provide more effective, personalized therapies, offering new treatment possibilities for patients facing difficult cancer types.



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