Celldex Therapeutics, Inc (NASDAQ:CLDX) Delivers Positive Mast-Cell Data; Cash-Rich Position Extends Runway For Near-Term Catalysts

Positive clinical readouts for mast-cell programs and a sizable equity raise position the company to advance multiple catalysts, though WMDST’s valuation classifies the stock as over-valued.

Recent News

On April 1, 2026 the company announced pricing of a proposed public offering for $300 million of common stock; the offering closed on April 6 with full exercise of the underwriters’ option. On May 7, 2026 Celldex reported first-quarter 2026 financial results and provided a corporate update. In mid-June the company presented long-term Phase 2 barzolvolimab results and positive Phase 1 CDX-622 data at the European Academy of Allergy and Clinical Immunology (EAACI) meeting, describing durable mast-cell control and dose-dependent mast-cell depletion with favorable safety signals.

Technical Analysis

Directional indicators show a bullish tilt: DI+ measured at 31.58 and trending increasing, while DI- sits at 14.85 and trends decreasing, indicating directional momentum favors buyers; ADX at 26.81 signals an emerging to established trend strength supporting that directional bias.

MACD registers 0.91 with the MACD line above the signal line at 0.29 and the MACD trend increasing; the cross above the signal line constitutes a bullish momentum confirmation and supports near-term upside pressure.

MRO stands at 26.46 and is increasing; because MRO > 0, price sits above the model target and that condition typically generates downward pressure, which may act as a counterbalance to the bullish MACD and DI+ signals.

RSI at 54.57 and rising indicates neutral-to-mild bullish momentum without overbought extremes, aligning with the momentum indicators while leaving room for continuation.

Price structure favors buyers: the close of $37.44 sits above the 12-day and 26-day EMAs ($33.56 and $32.45) and above the 20-day average ($32.64) and 200-day average ($28.33), with the 12-day EMA trending up—this alignment supports a near-term bullish price bias. The super trend lower support at $32.86 and the 20-day average around $32.64 form nearby technical support zones; Bollinger bands place the close near the upper two-standard-deviation band, indicating price near the short-term upper range and susceptibility to mean reversion. Volume roughly matches recent averages (10-day avg ~1.67M), providing typical participation rather than an extreme volume confirmation.

 


Fundamental Analysis

Cash position and liquidity present a strong buffer: cash and short-term investments total $451,458,000 and cash equals $35,729,000 at period end, while total debt remains minimal at $1,908,000; the current ratio equals 892.18% and the cash ratio equals 877.09%, indicating substantial short-term liquidity relative to liabilities that supports ongoing development spend and buffers near-term financing needs.

Operating performance remains deeply negative: operating income (EBIT) equals -$84,435,000 and EBIT margin registers -5,629.0%, a level well below the industry peer mean of -1.143%. QoQ improvement in EBIT margin equals 6.8151 percentage points and YoY improvement equals 61.35603 percentage points, reflecting sequential and annual margin moves but remaining far below profitable norms.

Revenue and growth metrics show minimal current sales with high percentage moves: total revenue equals $15,000; YoY revenue growth reads 114.445% and QoQ revenue growth reads 5.008%, reflecting very small base revenues driving large percentage swings. The price-to-sales ratio calculates to 136,913.47, a product of minimal revenue and market cap that reduces comparability to typical PS levels.

Earnings per share came in at -$1.18 versus an estimate of -$1.13, an EPS surprise of -4.43%. Forward EPS remains negative at approximately -$1.12, and trailing PE metrics show negative values, reflecting ongoing development-stage losses rather than earnings comparability.

Cash flow and burn: operating cash flow equals -$65,588,000 and free cash flow equals -$67,227,000, producing negative free cash flow yields and indicating ongoing cash consumption to fund R&D (R&D expense $73,001,000). Combined with the $451M in liquid securities, the company retains runway to advance clinical programs without material near-term debt issuance.

Valuation summary: WMDST values the stock as over-valued. The valuation reflects a disconnect between enterprise value/market cap and minimal current revenue plus deeply negative operating margins, even as positive clinical readouts and a large cash balance reduce immediate financing risk.

MOST-RECENT QUARTERLY REPORT
REPORT PERIOD ENDING: 2026-03-31
REPORT DATE: 2026-05-07
NEXT REPORT DATE: 2026-08-06
CASH FLOW  Begin Period Cash Flow 28.9 M
 Operating Cash Flow -65.59 M
 Capital Expenditures -1.64 M
 Change In Working Capital 4.3 M
 Dividends Paid
 Cash Flow Delta 6.9 M
 End Period Cash Flow 35.7 M
 
INCOME STATEMENT REVENUE
 Total Revenue 15.0 K
 Forward Revenue 3.6 K
COSTS
 Cost Of Revenue
 Depreciation 854.0 K
 Depreciation and Amortization 854.0 K
 Research and Development 73.0 M
 Total Operating Expenses 84.5 M
PROFITABILITY
 Gross Profit
 EBITDA -83.58 M
 EBIT -84.44 M
 Operating Income -84.44 M
 Interest Income
 Interest Expense
 Net Interest Income
 Income Before Tax -78.69 M
 Tax Provision
 Tax Rate
 Net Income -78.69 M
 Net Income From Continuing Operations -78.69 M
EARNINGS
 EPS Estimate -1.13
 EPS Actual -1.18
 EPS Difference -0.05
 EPS Surprise -4.425 %
 Forward EPS -1.12
 
BALANCE SHEET ASSETS
 Total Assets 511.3 M
 Intangible Assets 27.2 M
 Net Tangible Assets 429.0 M
 Total Current Assets 459.2 M
 Cash and Short-Term Investments 451.5 M
 Cash 35.7 M
 Net Receivables 230.0 K
 Inventory
 Long-Term Investments 634.0 K
LIABILITIES
 Accounts Payable 10.4 M
 Short-Term Debt
 Total Current Liabilities 51.5 M
 Net Debt
 Total Debt 1.9 M
 Total Liabilities 55.0 M
EQUITY
 Total Equity 456.2 M
 Retained Earnings -1.89 B
VALUATION & PER-SHARE METRICS EQUITY & PER-SHARE METRICS
 Book Value Per-Share 6.85
 Shares Outstanding 66.569 M
 Revenue Per-Share 0.00
VALUATION
 Market Capitalization 2.1 B
 Enterprise Value 1.6 B
 Enterprise Multiple -19.193
Enterprise Multiple QoQ 42.922 %
Enterprise Multiple YoY 75.093 %
Enterprise Multiple IPRWA high: 75.51
median: 27.492
mean: 7.265
CLDX: -19.193
low: -128.217
 EV/R 106943.468
CAPITAL STRUCTURE
 Asset To Equity 1.121
 Asset To Liability 9.291
 Debt To Capital 0.004
 Debt To Assets 0.004
Debt To Assets QoQ -6.983 %
Debt To Assets YoY -19.612 %
Debt To Assets IPRWA high: 1.112
mean: 0.168
median: 0.032
CLDX: 0.004
low: 0.0
 Debt To Equity 0.004
Debt To Equity QoQ -5.643 %
Debt To Equity YoY -14.344 %
Debt To Equity IPRWA high: 1.864
mean: 0.194
median: 0.051
CLDX: 0.004
low: -1.172
PRICE-BASED VALUATION
 Price To Book (P/B) 4.502
Price To Book QoQ 41.619 %
Price To Book YoY 134.74 %
Price To Book IPRWA high: 20.93
mean: 7.558
median: 5.613
CLDX: 4.502
low: -11.267
 Price To Earnings (P/E) -26.145
Price To Earnings QoQ 26.679 %
Price To Earnings YoY 4.285 %
Price To Earnings IPRWA high: 74.242
mean: -2.231
median: -14.301
CLDX: -26.145
low: -125.804
 PE/G Ratio 7.973
 Price To Sales (P/S) 136913.468
Price To Sales QoQ 888.665 %
Price To Sales YoY 6958.601 %
Price To Sales IPRWA CLDX: 136913.468
high: 864.732
mean: 64.578
median: 30.918
low: 0.192
FORWARD MULTIPLES
Forward P/E -24.566
Forward PE/G 7.492
Forward P/S 569365.682
EFFICIENCY OPERATIONAL
 Operating Leverage 0.036
ASSET & SALES
 Asset Turnover Ratio 0.0
Asset Turnover Ratio QoQ -100.0 %
Asset Turnover Ratio YoY -100.0 %
Asset Turnover Ratio IPRWA high: 0.403
mean: 0.103
median: 0.094
low: 0.0
CLDX: 0.0
 Receivables Turnover 0.013
Receivables Turnover Ratio QoQ -88.379 %
Receivables Turnover Ratio YoY -98.305 %
Receivables Turnover Ratio IPRWA high: 6.246
mean: 1.269
median: 1.226
low: 0.065
CLDX: 0.013
 Inventory Turnover
Inventory Turnover Ratio QoQ
Inventory Turnover Ratio YoY
Inventory Turnover Ratio IPRWA
 Days Sales Outstanding (DSO) 6828.542
CASH CYCLE
 Cash Conversion Cycle Days (CCC) 6828.542
Cash Conversion Cycle Days QoQ 760.317 %
Cash Conversion Cycle Days YoY 5796.731 %
Cash Conversion Cycle Days IPRWA CLDX: 6828.542
high: 1575.417
mean: 228.154
median: 208.031
low: -1586.264
CAPITAL DEPLOYMENT
 Cash Conversion Ratio 0.0
 CapEx To Revenue -109.267
 CapEx To Depreciation -1.919
 
CAPITAL, LIQUIDITY & COVERAGE CAPITAL STRUCTURE
 Total Capital 456.2 M
 Net Invested Capital 456.2 M
 Invested Capital 456.2 M
 Net Tangible Assets 429.0 M
 Net Working Capital 407.8 M
LIQUIDITY
 Cash Ratio 8.771
 Current Ratio 8.922
Current Ratio QoQ -14.913 %
Current Ratio YoY -58.825 %
Current Ratio IPRWA high: 32.587
CLDX: 8.922
mean: 3.942
median: 2.409
low: 0.016
 Quick Ratio
Quick Ratio QoQ
Quick Ratio YoY
Quick Ratio IPRWA
COVERAGE & LEVERAGE
 Debt To EBITDA -0.023
 Cost Of Debt 146.56 %
 Interest Coverage Ratio -27.15
Interest Coverage Ratio QoQ -3.119 %
Interest Coverage Ratio YoY 34.581 %
Interest Coverage Ratio IPRWA high: 604.866
median: -14.753
CLDX: -27.15
mean: -78.374
low: -1887.466
 Operating Cash Flow Ratio -1.299
TIMING / LIQUIDITY
 Days Payables Outstanding (DPO)
DIVIDENDS
 Dividend Coverage Ratio
 Dividend Payout Ratio
 Dividend Rate
 Dividend Yield
PERFORMANCE GROWTH
 Asset Growth Rate -12.304 %
 Revenue Growth -87.603 %
Revenue Growth QoQ 5.008 %
Revenue Growth YoY 114.445 %
Revenue Growth IPRWA high: 269.985 %
median: -7.18 %
mean: -9.943 %
CLDX: -87.603 %
low: -242.388 %
 Earnings Growth -3.279 %
Earnings Growth QoQ -115.77 %
Earnings Growth YoY -123.28 %
Earnings Growth IPRWA high: 200.0 %
CLDX: -3.279 %
median: -5.682 %
mean: -13.74 %
low: -250.0 %
MARGINS
 Gross Margin
Gross Margin QoQ
Gross Margin YoY
Gross Margin IPRWA
 EBIT Margin -562900.0 %
EBIT Margin QoQ 681.51 %
EBIT Margin YoY 6135.603 %
EBIT Margin IPRWA high: 2524.194 %
median: 23.412 %
mean: -114.303 %
low: -7259.515 %
CLDX: -562900.0 %
 Return On Sales (ROS) -562900.0 %
Return On Sales QoQ 681.51 %
Return On Sales YoY 6135.603 %
Return On Sales IPRWA high: 100.302 %
median: 20.658 %
mean: -114.307 %
low: -7394.476 %
CLDX: -562900.0 %
CASH FLOW
 Free Cash Flow (FCF) -67.23 M
 Free Cash Flow Yield -3.273 %
Free Cash Flow Yield QoQ -15.904 %
Free Cash Flow Yield YoY -19.245 %
Free Cash Flow Yield IPRWA high: 11.709 %
median: 0.11 %
mean: -0.512 %
CLDX: -3.273 %
low: -45.34 %
 Free Cash Growth 3.076 %
Free Cash Growth QoQ -90.656 %
Free Cash Growth YoY -95.224 %
Free Cash Growth IPRWA high: 253.163 %
mean: 4.281 %
CLDX: 3.076 %
median: -16.303 %
low: -249.577 %
 Free Cash To Net Income 0.854
 Cash Flow Margin -445780.0 %
 Cash Flow To Earnings 0.85
VALUE & RETURNS
 Economic Value Added
 Return On Assets (ROA) -14.382 %
Return On Assets QoQ 8.897 %
Return On Assets YoY 104.755 %
Return On Assets IPRWA high: 38.074 %
median: -8.157 %
mean: -13.757 %
CLDX: -14.382 %
low: -67.817 %
 Return On Capital Employed (ROCE) -18.364 %
 Return On Equity (ROE) -0.172
Return On Equity QoQ 11.812 %
Return On Equity YoY 125.363 %
Return On Equity IPRWA high: 0.797
median: -0.114
CLDX: -0.172
mean: -0.344
low: -1.265
 DuPont ROE 0.0 %
 Return On Invested Capital (ROIC)
Return On Invested Capital QoQ
Return On Invested Capital YoY
Return On Invested Capital IPRWA

Six-Week Outlook

Near-term price bias favors continuation of the recent rally, supported by bullish DI+, a MACD cross above its signal, rising short-term EMAs, and RSI in a constructive range; price above key moving averages and a $32.86 technical support level should limit immediate downside. Countervailing signals include a positive MRO—indicating price above modeled target and potential mean reversion—and a close positioned near upper Bollinger band, which increases the likelihood of pullbacks or consolidation. Expect volatility consistent with a beta near 1.1–1.6 and possible oscillation between the mid-$30s support band and the analyst mean target near $42.54; the company’s cash runway and fresh equity issuance reduce the probability of financing-driven downside in the six-week window, while clinical presentations remain the primary directional catalysts.

About Celldex Therapeutics, Inc.

Celldex Therapeutics, Inc. (NASDAQ:CLDX) develops advanced antibody-based therapeutics aimed at treating inflammatory, allergic, autoimmune, and other severe diseases. The company focuses on creating innovative monoclonal and bispecific antibodies, with a notable emphasis on CDX-0159, a Phase II monoclonal antibody targeting the receptor tyrosine kinase KIT. This therapeutic candidate holds potential for addressing challenging medical conditions. Founded in 1983, Celldex maintains its headquarters in Hampton, New Jersey. The company leverages cutting-edge scientific research to address unmet medical needs, collaborating with renowned institutions such as Yale University. These partnerships enhance Celldex’s research capabilities and expedite the development of its therapeutic candidates. Celldex Therapeutics actively contributes to the biopharmaceutical industry through strategic partnerships and a strong research framework. The company remains dedicated to improving patient outcomes and quality of life worldwide by developing transformative treatments.



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