Immunome, Inc. (NASDAQ:IMNM) Poised For Near-Term Momentum After Regulatory Filing And Pipeline Advances

Immunome shows strengthened liquidity and advancing clinical milestones that support a bullish near-term technical backdrop while fundamentals reflect continued R&D investment and negative operating results. WMDST values the stock as under-valued.

Recent News

On April 29, 2026 the company submitted a New Drug Application for varegacestat (AL102) for adults with desmoid tumors. On May 12, 2026 Immunome published first-quarter 2026 financial results and a program update noting expected initial lymphoma data for IM-1021 in 2026 and planned IND submissions for two ADC programs in mid- and late 2026. The company presented detailed Phase 3 RINGSIDE data for varegacestat at the 2026 ASCO Annual Meeting and announced an oral abstract selection. On June 11, 2026 Immunome reported dosing the first patient in a Phase 1 trial evaluating IM-1617, an ADC candidate for advanced solid tumors.

Technical Analysis

Directional indicators show emerging bullish pressure: ADX at 17.65 signals no strong trend, while DI+ at 22.51 increases and DI- at 23.26 decreases, which favors near-term upside potential tied to the company’s recent clinical and regulatory news.

MACD reads -0.52 and trends upward while the MACD line sits above the signal line (-0.72), a bullish momentum crossover that supports a short-term positive price bias consistent with improving momentum.

MRO registers 0.02 with a dip-and-reversal behavior; the positive value indicates price sits slightly above model target and suggests limited immediate upside potential before mean reversion pressures appear.

RSI at 44.67 and rising indicates building buying pressure without overbought conditions, aligning with momentum signals that favor controlled upside rather than an extended rally.

Price sits at $19.96 above the 12-day EMA ($19.26) and 20-day average ($18.77) but below the 50-day average ($21.25); this configuration suggests a short-term bullish tone while medium-term resistance near the 50-day average caps immediate extension. Ichimoku components place price below the cloud (Senkou A $22.53 / Senkou B $22.03) while the Tenkan-Sen ($19.45) sits below price, indicating short-term support inside a broader neutral-to-slightly-bearish cloud context.

Bollinger bands show modest dispersion (upper 1x std dev $19.49, lower 1x std dev $18.05) and volume has accelerated: latest session volume 4,301,513 exceeds the 10-day average 2,140,641 and 200-day average 1,613,761, signaling greater participation that supports the recent momentum pickup tied to clinical and regulatory headlines.

 


Fundamental Analysis

Liquidity stands as a primary strength: cash and short-term investments total $582,693,000 and current assets total $594,309,000 versus current liabilities $27,412,000, yielding a current ratio of 21.68 (up +47.62% QoQ; up +106.63% YoY). Cash conversion shows a net working capital position of $566,897,000 and a cash ratio near 21.26, indicating substantial runway to fund ongoing R&D through upcoming clinical inflection points.

R&D investment remains intensive: research and development expense for the period reached $46,381,000 while operating income and EBIT stayed negative at $-59,331,000, reflecting continued pre-commercial development spend. Net loss for the period measured $-53,839,000 and operating cash flow recorded $-50,891,000 for the period ended 2026-03-31. Free cash flow for the period totaled $-70,654,000 while free cash to net income exceeded 100% at 131.232%, indicating capital outflows that track but do not exceed reported losses.

Profitability ratios show ongoing development-stage metrics: return on assets at -8.26% and return on equity at -9.15%, both reflecting investment-led losses. Interest burden remains negligible given low leverage: debt to assets equals 0.596% and debt to equity equals 0.627%, underscoring a capital structure weighted toward equity and cash reserves.

Valuation multiples reflect the development profile: price-to-book stands at 4.24x, below the industry peer mean of 7.56 and below the industry peer median of 5.61, and falls inside the industry peer range that spans roughly -11.27 to 20.93 for P/B. Enterprise multiple reads negative at -32.71 owing to negative operating earnings; that multiple contrasts with an industry peer mean near 7.32 and median near 27.49. Forward EPS near $-0.524 produces a negative forward P/E of -42.23. Present cash and program milestones—most notably the NDA submission for varegacestat and ongoing early-stage ADC and radioligand programs—drive the WMDST valuation assessment.

Revenue growth shows material expansion in the reported periods: revenue growth equals 37.22% while revenue growth year-over-year reads 442.06%; treat the YoY magnitude as large relative to historical development-stage comparators. Operating metrics such as operating cash flow ratio and free cash flow yield remain negative at -1.85652 and -2.832% respectively, indicating ongoing cash burn despite a strong cash balance and capital base.

Brief valuation note: WMDST values the stock as under-valued based on current cash reserves, low leverage, and near-term clinical and regulatory milestones that could re-rate multiples; negative operating earnings and continued R&D outlays justify a risk premium on that valuation until commercial revenue streams emerge.

MOST-RECENT QUARTERLY REPORT
REPORT PERIOD ENDING: 2026-03-31
REPORT DATE: 2026-06-02
NEXT REPORT DATE: 2026-09-01
CASH FLOW  Begin Period Cash Flow 653.7 M
 Operating Cash Flow -50.89 M
 Capital Expenditures -12.02 M
 Change In Working Capital -13.58 M
 Dividends Paid
 Cash Flow Delta -70.79 M
 End Period Cash Flow 582.9 M
 
INCOME STATEMENT REVENUE
 Total Revenue
 Forward Revenue
COSTS
 Cost Of Revenue
 Depreciation 753.0 K
 Depreciation and Amortization 753.0 K
 Research and Development 46.4 M
 Total Operating Expenses 59.3 M
PROFITABILITY
 Gross Profit
 EBITDA -58.58 M
 EBIT -59.33 M
 Operating Income -59.33 M
 Interest Income 5.5 M
 Interest Expense
 Net Interest Income 5.5 M
 Income Before Tax -53.84 M
 Tax Provision
 Tax Rate
 Net Income -53.84 M
 Net Income From Continuing Operations -53.84 M
EARNINGS
 EPS Estimate
 EPS Actual
 EPS Difference
 EPS Surprise
 Forward EPS -0.52
 
BALANCE SHEET ASSETS
 Total Assets 619.8 M
 Intangible Assets
 Net Tangible Assets 588.7 M
 Total Current Assets 594.3 M
 Cash and Short-Term Investments 582.7 M
 Cash 582.7 M
 Net Receivables
 Inventory
 Long-Term Investments 5.6 M
LIABILITIES
 Accounts Payable 5.5 M
 Short-Term Debt
 Total Current Liabilities 27.4 M
 Net Debt
 Total Debt 3.7 M
 Total Liabilities 31.1 M
EQUITY
 Total Equity 588.7 M
 Retained Earnings -782.00 M
VALUATION & PER-SHARE METRICS EQUITY & PER-SHARE METRICS
 Book Value Per-Share 5.20
 Shares Outstanding 113.171 M
 Revenue Per-Share
VALUATION
 Market Capitalization 2.5 B
 Enterprise Value 1.9 B
 Enterprise Multiple -32.709
Enterprise Multiple QoQ 31.544 %
Enterprise Multiple YoY 240.842 %
Enterprise Multiple IPRWA high: 75.51
median: 27.492
mean: 7.323
IMNM: -32.709
low: -128.217
 EV/R
CAPITAL STRUCTURE
 Asset To Equity 1.053
 Asset To Liability 19.925
 Debt To Capital 0.006
 Debt To Assets 0.006
Debt To Assets QoQ 5.674 %
Debt To Assets YoY -57.184 %
Debt To Assets IPRWA high: 1.112
mean: 0.168
median: 0.032
IMNM: 0.006
low: 0.0
 Debt To Equity 0.006
Debt To Equity QoQ 3.125 %
Debt To Equity YoY -59.627 %
Debt To Equity IPRWA high: 1.864
mean: 0.194
median: 0.051
IMNM: 0.006
low: -1.172
PRICE-BASED VALUATION
 Price To Book (P/B) 4.238
Price To Book QoQ 10.093 %
Price To Book YoY 77.358 %
Price To Book IPRWA high: 20.93
mean: 7.56
median: 5.613
IMNM: 4.238
low: -11.267
 Price To Earnings (P/E)
Price To Earnings QoQ
Price To Earnings YoY
Price To Earnings IPRWA
 PE/G Ratio
 Price To Sales (P/S)
Price To Sales QoQ
Price To Sales YoY
Price To Sales IPRWA
FORWARD MULTIPLES
Forward P/E -42.226
Forward PE/G
Forward P/S
EFFICIENCY OPERATIONAL
 Operating Leverage
ASSET & SALES
 Asset Turnover Ratio
Asset Turnover Ratio QoQ
Asset Turnover Ratio YoY
Asset Turnover Ratio IPRWA
 Receivables Turnover
Receivables Turnover Ratio QoQ
Receivables Turnover Ratio YoY
Receivables Turnover Ratio IPRWA
 Inventory Turnover
Inventory Turnover Ratio QoQ
Inventory Turnover Ratio YoY
Inventory Turnover Ratio IPRWA
 Days Sales Outstanding (DSO)
CASH CYCLE
 Cash Conversion Cycle Days (CCC)
Cash Conversion Cycle Days QoQ
Cash Conversion Cycle Days YoY
Cash Conversion Cycle Days IPRWA high: 499.798
mean: 219.741
median: 208.031
IMNM: 0
low: -303.652
CAPITAL DEPLOYMENT
 Cash Conversion Ratio
 CapEx To Revenue
 CapEx To Depreciation -15.957
 
CAPITAL, LIQUIDITY & COVERAGE CAPITAL STRUCTURE
 Total Capital 588.7 M
 Net Invested Capital 588.7 M
 Invested Capital 588.7 M
 Net Tangible Assets 588.7 M
 Net Working Capital 566.9 M
LIQUIDITY
 Cash Ratio 21.257
 Current Ratio 21.681
Current Ratio QoQ 47.616 %
Current Ratio YoY 106.634 %
Current Ratio IPRWA high: 32.587
IMNM: 21.681
mean: 3.923
median: 2.409
low: 0.016
 Quick Ratio
Quick Ratio QoQ
Quick Ratio YoY
Quick Ratio IPRWA
COVERAGE & LEVERAGE
 Debt To EBITDA -0.063
 Cost Of Debt 5.325 %
 Interest Coverage Ratio -295.179
Interest Coverage Ratio QoQ -18.57 %
Interest Coverage Ratio YoY 32.922 %
Interest Coverage Ratio IPRWA high: 604.866
median: -14.753
mean: -78.012
IMNM: -295.179
low: -1887.466
 Operating Cash Flow Ratio -1.857
TIMING / LIQUIDITY
 Days Payables Outstanding (DPO)
DIVIDENDS
 Dividend Coverage Ratio
 Dividend Payout Ratio
 Dividend Rate
 Dividend Yield
PERFORMANCE GROWTH
 Asset Growth Rate -9.279 %
 Revenue Growth 37.218 %
Revenue Growth QoQ 0.0 %
Revenue Growth YoY 442.062 %
Revenue Growth IPRWA high: 242.212 %
IMNM: 37.218 %
median: -7.18 %
mean: -10.281 %
low: -242.388 %
 Earnings Growth
Earnings Growth QoQ
Earnings Growth YoY
Earnings Growth IPRWA
MARGINS
 Gross Margin
Gross Margin QoQ
Gross Margin YoY
Gross Margin IPRWA
 EBIT Margin
EBIT Margin QoQ
EBIT Margin YoY
EBIT Margin IPRWA
 Return On Sales (ROS)
Return On Sales QoQ
Return On Sales YoY
Return On Sales IPRWA
CASH FLOW
 Free Cash Flow (FCF) -70.65 M
 Free Cash Flow Yield -2.832 %
Free Cash Flow Yield QoQ 33.145 %
Free Cash Flow Yield YoY -66.989 %
Free Cash Flow Yield IPRWA high: 11.709 %
median: 0.11 %
mean: -0.512 %
IMNM: -2.832 %
low: -45.34 %
 Free Cash Growth 35.999 %
Free Cash Growth QoQ 45.116 %
Free Cash Growth YoY -19.942 %
Free Cash Growth IPRWA high: 253.163 %
IMNM: 35.999 %
mean: 4.232 %
median: -16.303 %
low: -249.577 %
 Free Cash To Net Income 1.312
 Cash Flow Margin
 Cash Flow To Earnings 0.945
VALUE & RETURNS
 Economic Value Added
 Return On Assets (ROA) -8.264 %
Return On Assets QoQ -41.917 %
Return On Assets YoY -42.153 %
Return On Assets IPRWA high: 38.074 %
median: -8.157 %
IMNM: -8.264 %
mean: -13.765 %
low: -67.817 %
 Return On Capital Employed (ROCE) -10.016 %
 Return On Equity (ROE) -0.091
Return On Equity QoQ -16.998 %
Return On Equity YoY -32.542 %
Return On Equity IPRWA high: 0.797
IMNM: -0.091
median: -0.115
mean: -0.344
low: -1.265
 DuPont ROE
 Return On Invested Capital (ROIC)
Return On Invested Capital QoQ
Return On Invested Capital YoY
Return On Invested Capital IPRWA

Six-Week Outlook

Clinical and regulatory catalysts—an active NDA for varegacestat and early-stage ADC/RLT updates—should drive news flow and trading interest over the next six weeks. Technicals favor measured upside: a bullish MACD crossover, rising RSI, and higher-than-average volume support continuation toward the 50-day average near $21.25, while MRO and the Ichimoku cloud warn of limited extension without confirmatory follow-through. Maintain focus on event-driven headlines and volume-confirmed moves; absence of fresh positive data would likely keep price contained between the 20-day and 50-day averages.

About Immunome, Inc.

Immunome, Inc. (NASDAQ:IMNM) develops innovative cancer therapies by leveraging the body’s immune system. Headquartered in Bothell, Washington, Immunome advances its clinical pipeline with AL102, a gamma secretase inhibitor in Phase 3 trials targeting desmoid tumors. The company’s portfolio includes preclinical assets such as IM-1021, focusing on receptor tyrosine kinase-like orphan receptor 1, and antibody-drug conjugates aimed at delivering anti-cancer agents directly to tumor cells. Immunome also explores IM-3050, a fibroblast activation protein-targeted radioligand therapy, and IM-4320, an anti-IL-38 immunotherapy candidate designed to modulate immune responses in cancer. Through cutting-edge research, Immunome commits to transforming oncology therapeutics and providing hope to patients with limited treatment options.



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