Illumina, Inc (NASDAQ:ILMN) Accelerates Multiomics Expansion After SomaLogic Close

Momentum in corporate strategy and product-level reimbursement shifted the narrative toward multiomics expansion; near-term price action must reconcile bullish momentum with constrained trend strength.

Recent News

On January 30–31, 2026 Illumina completed its acquisition of SomaLogic, acquiring proteomics assets for $350 million upfront plus potential milestone payments; the company positioned the deal as accelerating its multiomics roadmap. On January 1, 2026 the TruSight Oncology Comprehensive test received Centers for Medicare & Medicaid Services reimbursement at $2,989.55 per test. March 2026 options chains for Illumina became available with standard expirations expanding derivative liquidity.

Technical Analysis

ADX at 17.75 indicates no established trend; directional indicators present a directional tussle: DI+ registered 18.28 and shows a peak-and-reversal (bearish signal), while DI– sits at 21.44 and trends decreasing (bullish signal for directional pressure). Together these readings imply trend weakness and limited conviction relative to the current valuation, supporting a near-term range bias rather than a sustained breakout.

MACD reads −1.03 with the MACD line above its signal (MACD signal −1.74) while the MACD trend increases; the MACD crossing above its signal line qualifies as an active bullish momentum signal despite the negative absolute level, suggesting momentum has shifted from more negative territory toward constructive momentum that could support price upside if it sustains.

MRO sits at 11.75 and trends increasing; the positive MRO indicates price currently resides above internal target levels and therefore faces potential downward pressure to re-align with target—this condition limits the stamina of any short-term rally and weighs against extended upside without reinvigorated buying volume.

RSI at 48.68 shows a recent peak-and-reversal pattern; that pattern implies loss of prior upward rate and adds a bearish tilt to momentum despite the neutral numeric reading near 50, reinforcing the view that rallies may encounter resistance absent stronger trend confirmation.

Price structure conveys mixed support: closing price $124.40 sits below the 50-day average $129.90, above the 20-day average $122.64 and above the 200-day average $113.89, while the 12-day EMA at $124.10 trends higher. Bollinger bands place price well within 1× standard deviation (upper ~ $126.17, lower ~ $119.11). Volume at 962,238 trails 10-, 50-, and 200-day averages, signaling lower conviction behind recent moves. Collectively the technicals favor a range-bound near-term outlook where MACD-driven rallies face resistance from MRO and directional indicators until volume and ADX confirm trend strength.

 


Fundamental Analysis

Profitability: Operating margin registers 20.94% and EBIT margin 22.60%; EBIT margin sits above the industry peer mean of 15.82% and above the industry peer median of 19.54%, indicating relative operational efficiency versus peers. QoQ EBIT margin contracted −27.69% and YoY contracted −67.71%, signaling meaningful margin compression over reported intervals despite the still-elevated headline margin.

Growth and earnings: Total revenue reached $1,084,000,000 with revenue per share $7.08; reported revenue growth stands at 2.36% (trailing), QoQ revenue growth accelerated 36.55% while revenue growth YoY shows −182.04% per the supplied figure—these numbers indicate uneven timing effects across periods and require careful read alongside reported quarter detail. Reported EPS came in at $1.35 versus estimate $1.23, producing an EPS surprise of 9.76%.

Cash flow & liquidity: Operating cash flow $284,000,000 and free cash flow $260,000,000 yield a free cash flow yield of 1.75%, above the industry peer mean free cash flow yield of 0.87% (0.00869 expressed), and free cash flow growth QoQ surged 1,738.65% while free cash flow growth YoY declined −94.28%, reflecting timing and acquisition effects. Cash and short-term investments total $1,278,000,000 and cash ratio 0.65; current ratio stands at 1.43 and quick ratio 1.12, both below the industry peer mean current ratio of 2.05 but near the industry peer median quick ratio of 1.11—liquidity adequate but tighter than some peers.

Leverage and coverage: Total debt $2,576,000,000 produces debt-to-equity 108.19% and debt-to-assets 41.70%; debt-to-EBITDA reads 8.26x while interest coverage sits at 9.8x. The debt-to-equity level exceeds the industry peer mean of 63.14% and the industry peer median of 69.94%, reflecting higher leverage following strategic transactions and a leverage profile that heightens sensitivity to cash-flow variability.

Valuation: Price-to-earnings at 72.59x and forward P/E near 76.69x reflect premium expectations versus long-run growth; price-to-book near 6.25x sits above the industry peer mean price-to-book of 3.98 and below the industry peer high of 8.27. Enterprise multiple registers ~51.86. WMDST values the stock as fair-valued; the valuation implies the market prices a premium for multiomics optionality and expected margin recovery, while cash-flow yields and leverage suggest limited immediate valuation upside without clearer growth stabilization.

MOST-RECENT QUARTERLY REPORT
REPORT PERIOD ENDING: 2025-09-30
REPORT DATE: 2026-02-05
NEXT REPORT DATE: 2026-05-07
CASH FLOW  Begin Period Cash Flow 934.0 M
 Operating Cash Flow 284.0 M
 Capital Expenditures -24.00 M
 Change In Working Capital -56.00 M
 Dividends Paid
 Cash Flow Delta 116.0 M
 End Period Cash Flow 1.1 B
 
INCOME STATEMENT REVENUE
 Total Revenue 1.1 B
 Forward Revenue 401.2 M
COSTS
 Cost Of Revenue 351.0 M
 Depreciation 50.0 M
 Depreciation and Amortization 67.0 M
 Research and Development 229.0 M
 Total Operating Expenses 857.0 M
PROFITABILITY
 Gross Profit 733.0 M
 EBITDA 312.0 M
 EBIT 245.0 M
 Operating Income 227.0 M
 Interest Income 9.0 M
 Interest Expense 25.0 M
 Net Interest Income -16.00 M
 Income Before Tax 220.0 M
 Tax Provision 70.0 M
 Tax Rate 31.8 %
 Net Income 150.0 M
 Net Income From Continuing Operations 150.0 M
EARNINGS
 EPS Estimate 1.23
 EPS Actual 1.35
 EPS Difference 0.12
 EPS Surprise 9.756 %
 Forward EPS 1.45
 
BALANCE SHEET ASSETS
 Total Assets 6.2 B
 Intangible Assets 1.3 B
 Net Tangible Assets 1.0 B
 Total Current Assets 2.8 B
 Cash and Short-Term Investments 1.3 B
 Cash 1.1 B
 Net Receivables 729.0 M
 Inventory 590.0 M
 Long-Term Investments 423.0 M
LIABILITIES
 Accounts Payable 218.0 M
 Short-Term Debt 998.0 M
 Total Current Liabilities 2.0 B
 Net Debt 942.0 M
 Total Debt 2.6 B
 Total Liabilities 3.8 B
EQUITY
 Total Equity 2.4 B
 Retained Earnings -726.00 M
VALUATION & PER-SHARE METRICS EQUITY & PER-SHARE METRICS
 Book Value Per-Share 15.56
 Shares Outstanding 153.000 M
 Revenue Per-Share 7.08
VALUATION
 Market Capitalization 14.9 B
 Enterprise Value 16.2 B
 Enterprise Multiple 51.86
Enterprise Multiple QoQ 23.093 %
Enterprise Multiple YoY 109.693 %
Enterprise Multiple IPRWA high: 162.48
median: 76.714
mean: 73.966
ILMN: 51.86
low: -116.757
 EV/R 14.927
CAPITAL STRUCTURE
 Asset To Equity 2.594
 Asset To Liability 1.627
 Debt To Capital 0.52
 Debt To Assets 0.417
Debt To Assets QoQ -2.291 %
Debt To Assets YoY 3335.173 %
Debt To Assets IPRWA high: 0.872
ILMN: 0.417
median: 0.346
mean: 0.318
low: 0.051
 Debt To Equity 1.082
Debt To Equity QoQ -5.969 %
Debt To Equity YoY 3049.636 %
Debt To Equity IPRWA high: 1.499
ILMN: 1.082
median: 0.699
mean: 0.631
low: 0.069
PRICE-BASED VALUATION
 Price To Book (P/B) 6.25
Price To Book QoQ -8.158 %
Price To Book YoY -37.625 %
Price To Book IPRWA high: 8.27
ILMN: 6.25
mean: 3.977
median: 3.632
low: 0.319
 Price To Earnings (P/E) 72.59
Price To Earnings QoQ -8.324 %
Price To Earnings YoY -38.599 %
Price To Earnings IPRWA high: 296.869
mean: 94.65
median: 85.169
ILMN: 72.59
low: -68.169
 PE/G Ratio 5.759
 Price To Sales (P/S) 13.729
Price To Sales QoQ -5.389 %
Price To Sales YoY -30.369 %
Price To Sales IPRWA high: 40.709
mean: 18.045
median: 16.658
ILMN: 13.729
low: 0.314
FORWARD MULTIPLES
Forward P/E 76.691
Forward PE/G 6.084
Forward P/S 42.519
EFFICIENCY OPERATIONAL
 Operating Leverage -11.006
ASSET & SALES
 Asset Turnover Ratio 0.177
Asset Turnover Ratio QoQ 2.404 %
Asset Turnover Ratio YoY -1.013 %
Asset Turnover Ratio IPRWA high: 0.18
ILMN: 0.177
mean: 0.115
median: 0.109
low: 0.032
 Receivables Turnover 1.516
Receivables Turnover Ratio QoQ 0.213 %
Receivables Turnover Ratio YoY -5.947 %
Receivables Turnover Ratio IPRWA high: 2.035
ILMN: 1.516
mean: 1.338
median: 1.271
low: 0.971
 Inventory Turnover 0.603
Inventory Turnover Ratio QoQ -7.958 %
Inventory Turnover Ratio YoY 2.079 %
Inventory Turnover Ratio IPRWA high: 2.315
median: 1.157
mean: 1.027
ILMN: 0.603
low: 0.205
 Days Sales Outstanding (DSO) 60.188
CASH CYCLE
 Cash Conversion Cycle Days (CCC) 153.819
Cash Conversion Cycle Days QoQ 2.434 %
Cash Conversion Cycle Days YoY 7.16 %
Cash Conversion Cycle Days IPRWA high: 485.842
ILMN: 153.819
mean: 129.103
median: 108.644
low: 47.665
CAPITAL DEPLOYMENT
 Cash Conversion Ratio 1.3
 CapEx To Revenue -0.022
 CapEx To Depreciation -0.48
 
CAPITAL, LIQUIDITY & COVERAGE CAPITAL STRUCTURE
 Total Capital 3.4 B
 Net Invested Capital 4.4 B
 Invested Capital 4.4 B
 Net Tangible Assets 1.0 B
 Net Working Capital 834.0 M
LIQUIDITY
 Cash Ratio 0.651
 Current Ratio 1.425
Current Ratio QoQ -21.165 %
Current Ratio YoY -41.448 %
Current Ratio IPRWA high: 8.361
mean: 2.053
median: 1.498
ILMN: 1.425
low: 0.349
 Quick Ratio 1.124
Quick Ratio QoQ -20.489 %
Quick Ratio YoY -39.063 %
Quick Ratio IPRWA high: 7.268
mean: 1.558
ILMN: 1.124
median: 1.112
low: 0.267
COVERAGE & LEVERAGE
 Debt To EBITDA 8.256
 Cost Of Debt 0.659 %
 Interest Coverage Ratio 9.8
Interest Coverage Ratio QoQ -25.982 %
Interest Coverage Ratio YoY -53.333 %
Interest Coverage Ratio IPRWA high: 17.394
ILMN: 9.8
mean: 6.475
median: 6.262
low: -34.049
 Operating Cash Flow Ratio 0.098
TIMING / LIQUIDITY
 Days Payables Outstanding (DPO) 52.394
DIVIDENDS
 Dividend Coverage Ratio
 Dividend Payout Ratio
 Dividend Rate
 Dividend Yield
PERFORMANCE GROWTH
 Asset Growth Rate 1.479 %
 Revenue Growth 2.361 %
Revenue Growth QoQ 36.553 %
Revenue Growth YoY -182.036 %
Revenue Growth IPRWA high: 12.006 %
median: 2.469 %
ILMN: 2.361 %
mean: 2.077 %
low: -19.725 %
 Earnings Growth 12.605 %
Earnings Growth QoQ -44.422 %
Earnings Growth YoY -94.182 %
Earnings Growth IPRWA high: 40.625 %
ILMN: 12.605 %
median: 8.022 %
mean: 4.65 %
low: -107.143 %
MARGINS
 Gross Margin 67.62 %
Gross Margin QoQ 3.035 %
Gross Margin YoY -1.973 %
Gross Margin IPRWA high: 87.843 %
ILMN: 67.62 %
mean: 45.727 %
median: 41.207 %
low: 8.88 %
 EBIT Margin 22.601 %
EBIT Margin QoQ -27.691 %
EBIT Margin YoY -67.713 %
EBIT Margin IPRWA high: 34.151 %
ILMN: 22.601 %
median: 19.538 %
mean: 15.824 %
low: -168.218 %
 Return On Sales (ROS) 20.941 %
Return On Sales QoQ 3.627 %
Return On Sales YoY -70.084 %
Return On Sales IPRWA high: 35.591 %
ILMN: 20.941 %
median: 18.657 %
mean: 17.128 %
low: -162.41 %
CASH FLOW
 Free Cash Flow (FCF) 260.0 M
 Free Cash Flow Yield 1.747 %
Free Cash Flow Yield QoQ 31.65 %
Free Cash Flow Yield YoY 30.96 %
Free Cash Flow Yield IPRWA high: 2.65 %
ILMN: 1.747 %
median: 0.99 %
mean: 0.869 %
low: -10.147 %
 Free Cash Growth 27.451 %
Free Cash Growth QoQ 1738.647 %
Free Cash Growth YoY -94.276 %
Free Cash Growth IPRWA high: 163.652 %
median: 66.063 %
mean: 63.439 %
ILMN: 27.451 %
low: -201.519 %
 Free Cash To Net Income 1.733
 Cash Flow Margin 17.712 %
 Cash Flow To Earnings 1.28
VALUE & RETURNS
 Economic Value Added 0.04
 Return On Assets (ROA) 2.446 %
Return On Assets QoQ -36.152 %
Return On Assets YoY -79.019 %
Return On Assets IPRWA high: 3.109 %
ILMN: 2.446 %
median: 1.582 %
mean: 1.484 %
low: -14.382 %
 Return On Capital Employed (ROCE) 5.813 %
 Return On Equity (ROE) 0.063
Return On Equity QoQ -39.464 %
Return On Equity YoY -81.01 %
Return On Equity IPRWA high: 0.064
ILMN: 0.063
median: 0.032
mean: 0.03
low: -0.26
 DuPont ROE 6.467 %
 Return On Invested Capital (ROIC) 3.821 %
Return On Invested Capital QoQ -36.136 %
Return On Invested Capital YoY -104.471 %
Return On Invested Capital IPRWA high: 4.606 %
ILMN: 3.821 %
median: 2.222 %
mean: 2.106 %
low: -13.889 %

Six-Week Outlook

Expect range-bound swing behavior while momentum indicators determine direction. Bullish confirmation requires sustained MACD momentum above its signal line paired with rising short-term EMAs and a pickup in volume; bearish pressure would gain follow-through if MRO-driven alignment and the RSI peak-and-reversal coincide with renewed DI+ weakness and ADX remaining below trend-threshold. Near-term catalysts include SomaLogic integration updates and reimbursement rollouts; monitor liquidity and operating-margin QoQ prints for signals that validate the current fair-valued assessment.

About Illumina, Inc.

Illumina, Inc. (NASDAQ:ILMN) develops and supplies advanced genetic and genomic analysis tools. Based in San Diego, California, the company offers a wide range of sequencing and array-based solutions that address various genomic needs. Illumina’s portfolio includes high-performance sequencing instruments, essential reagents, and consumables, as well as comprehensive whole-genome and targeted resequencing kits. The company’s technological advancements support critical healthcare applications, including noninvasive prenatal testing and cancer diagnostics, such as the Galleri multi-cancer early detection test. Illumina’s innovations facilitate the detection of minimal residual disease through blood-based diagnostics, contributing to improved post-diagnostic care. Illumina serves a diverse clientele, including genomic research centers, academic institutions, and companies in the pharmaceutical and biotechnology sectors. By distributing its products directly and through life-science distributors, Illumina aims to advance scientific discovery and enhance human health globally. Through its Core Illumina and GRAIL segments, the company continues to lead in the development of technologies that drive progress in genomics.



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