IDEAYA Biosciences, Inc. (NASDAQ:IDYA) Accelerates Clinical Readouts, Supporting Near-Term Upside Potential

Robust cash reserves and an active clinical-catalyst schedule through early September create a constructive near-term backdrop for the stock. Multiple pipeline updates and an expanding combination program underpin a positive operational narrative.

Recent News

On September 8, 2025 IDEAYA announced an in-person and virtual R&D Day in New York to present multiple clinical data updates across the pipeline and outline its next growth priorities. On September 4, 2025 the company reported dosing the first patient in the Phase 1/2 IDE397 plus Trodelvy combination trial for MTAP-deletion non-small cell lung cancer, noting prior expansion from urothelial cancer. The R&D Day agenda listed darovasertib neoadjuvant uveal melanoma data, IDE849 DLL3 TOP1 ADC clinical data, and IDE397 combination findings among the presentations.

Technical Analysis

ADX / DI+ / DI-: ADX at 38.22 indicates a strong trend in place. DIpositive registered a peak-and-reversal, which signals a bearish directional shift; DInegative is decreasing, which supports bullish directional pressure. The combination suggests a strong trend with conflicting directional signals that merit close monitoring against valuation levels.

MACD: MACD sits at 1.23 and recently crossed above its signal line at 1.13; MACD is increasing, which indicates bullish momentum and supports upside pressure relative to current valuation.

MRO: MRO equals 17.78 (positive), which indicates price sits above the model target and creates potential for downward mean reversion toward fair value.

RSI: RSI at 61.39 and increasing implies ongoing buying momentum without extreme overbought conditions.

Price vs Moving Averages and Bands: Last close $33.99 sits above the 20-day average $31.88, 50-day average $29.01 and 200-day average $22.91; the 12-day EMA is increasing. Bollinger upper band near $33.52 and the 52-week high $34.66 place the stock close to shorter-term resistance, while the super trend lower at $30.39 and ichimoku Tenkan/Kijun near $31.75/$30.77 provide nearby support levels.

Volume & Volatility: Today’s volume below recent averages (volume 587,433 vs 10-/50-/200-day averages) suggests thinner participation during the recent price run; 42-day beta 1.51 signals elevated responsiveness to market moves.

 


Fundamental Analysis

Profitability & Margins: Operating income $108,452,000 and operating margin 52.18% reflect strong operating leverage. That operating margin sits above the industry peer mean of -114.10% and peer median of 35.35% (industry peer mean/median provided), indicating materially stronger margin performance versus those peers.

Cash & Liquidity: Cash $298,927,000 and cash and short-term investments $786,894,000 provide substantial liquidity against total current liabilities $64,509,000. The current ratio equals 12.44 and the cash ratio equals 12.20, both well above typical peer metrics and supporting funding of operations without near-term financing stress.

Revenue & Earnings Growth: Total revenue $207,834,000 and YoY revenue growth 28.69% indicate meaningful top-line expansion. Earnings growth shows a QoQ contraction of 35.32% but a YoY improvement of 20.35%, reflecting quarter-to-quarter volatility alongside year-over-year recovery.

Valuation Multiples & Cash Flow: PE ratio stands at 20.28x and enterprise multiple at 14.66x. Free cash flow $142,172,000 yields 6.01%, and free cash flow converts at roughly 1.19x net income. WMDST values the stock as under-valued based on the combination of positive free cash flow yield, moderate multiples, and a strong cash buffer.

Capital Structure: Total debt $27,245,000 yields debt-to-assets of 2.30% and debt-to-equity of 2.50%, both low and consistent with a conservative leverage profile relative to typical industry ranges.

MOST-RECENT QUARTERLY REPORT
REPORT PERIOD ENDING: 2025-09-30
REPORT DATE: 2025-11-04
NEXT REPORT DATE: 2026-02-03
CASH FLOW  Begin Period Cash Flow $ 115.5 M
 Operating Cash Flow $ 142.2 M
 Capital Expenditures $ -42.00 K
 Change In Working Capital $ 11.7 M
 Dividends Paid —
 Cash Flow Delta $ 184.3 M
 End Period Cash Flow $ 299.7 M
 
INCOME STATEMENT REVENUE
 Total Revenue $ 207.8 M
 Forward Revenue $ -25.98 M
COSTS
 Cost Of Revenue —
 Depreciation $ 1.0 M
 Depreciation and Amortization $ 1.0 M
 Research and Development $ 83.0 M
 Total Operating Expenses $ 99.4 M
PROFITABILITY
 Gross Profit —
 EBITDA $ 109.5 M
 EBIT $ 108.5 M
 Operating Income $ 108.5 M
 Interest Income $ 10.8 M
 Interest Expense —
 Net Interest Income $ 10.8 M
 Income Before Tax $ 119.2 M
 Tax Provision —
 Tax Rate 21.0 %
 Net Income $ 119.2 M
 Net Income From Continuing Operations $ 119.2 M
EARNINGS
 EPS Estimate $ -0.55
 EPS Actual $ 1.33
 EPS Difference $ 1.88
 EPS Surprise 341.818 %
 Forward EPS $ -0.68
 
BALANCE SHEET ASSETS
 Total Assets $ 1.2 B
 Intangible Assets —
 Net Tangible Assets $ 1.1 B
 Total Current Assets $ 802.7 M
 Cash and Short-Term Investments $ 786.9 M
 Cash $ 298.9 M
 Net Receivables —
 Inventory —
 Long-Term Investments $ 805.0 K
LIABILITIES
 Accounts Payable $ 18.4 M
 Short-Term Debt —
 Total Current Liabilities $ 64.5 M
 Net Debt —
 Total Debt $ 27.2 M
 Total Liabilities $ 93.1 M
EQUITY
 Total Equity $ 1.1 B
 Retained Earnings $ -653.27 M
VALUATION & PER-SHARE METRICS EQUITY & PER-SHARE METRICS
 Book Value Per-Share $ 12.46
 Shares Outstanding 87.666 M
 Revenue Per-Share $ 2.37
VALUATION
 Market Capitalization $ 2.4 B
 Enterprise Value $ 1.6 B
 Enterprise Multiple 14.655
Enterprise Multiple QoQ -193.146 %
Enterprise Multiple YoY -149.007 %
Enterprise Multiple IPRWA high: 52.77
median: 26.559
IDYA: 14.655
mean: 3.653
low: -80.476
 EV/R 7.72
CAPITAL STRUCTURE
 Asset To Equity 1.085
 Asset To Liability 12.729
 Debt To Capital 0.024
 Debt To Assets 0.023
Debt To Assets QoQ -9.984 %
Debt To Assets YoY 51.649 %
Debt To Assets IPRWA high: 1.045
mean: 0.214
median: 0.075
IDYA: 0.023
low: 0.0
 Debt To Equity 0.025
Debt To Equity QoQ -9.993 %
Debt To Equity YoY 56.721 %
Debt To Equity IPRWA high: 1.395
mean: 0.194
median: 0.09
IDYA: 0.025
low: -0.869
PRICE-BASED VALUATION
 Price To Book (P/B) 2.165
Price To Book QoQ 2.798 %
Price To Book YoY -11.001 %
Price To Book IPRWA high: 18.42
mean: 7.012
median: 5.8
IDYA: 2.165
low: -8.555
 Price To Earnings (P/E) 20.276
Price To Earnings QoQ -181.484 %
Price To Earnings YoY -136.589 %
Price To Earnings IPRWA high: 56.753
IDYA: 20.276
mean: -3.805
median: -12.252
low: -93.179
 PE/G Ratio -0.081
 Price To Sales (P/S) 11.375
Price To Sales QoQ —
Price To Sales YoY —
Price To Sales IPRWA high: 1129.647
mean: 73.695
median: 25.506
IDYA: 11.375
low: 0.808
FORWARD MULTIPLES
Forward P/E -35.568
Forward PE/G 0.142
Forward P/S -91.015
EFFICIENCY OPERATIONAL
 Operating Leverage —
ASSET & SALES
 Asset Turnover Ratio 0.187
Asset Turnover Ratio QoQ —
Asset Turnover Ratio YoY —
Asset Turnover Ratio IPRWA high: 0.438
IDYA: 0.187
mean: 0.117
median: 0.107
low: 0.0
 Receivables Turnover —
Receivables Turnover Ratio QoQ —
Receivables Turnover Ratio YoY —
Receivables Turnover Ratio IPRWA —
 Inventory Turnover —
Inventory Turnover Ratio QoQ —
Inventory Turnover Ratio YoY —
Inventory Turnover Ratio IPRWA —
 Days Sales Outstanding (DSO) —
CASH CYCLE
 Cash Conversion Cycle Days (CCC) —
Cash Conversion Cycle Days QoQ —
Cash Conversion Cycle Days YoY —
Cash Conversion Cycle Days IPRWA high: 520.898
median: 189.366
mean: 166.152
IDYA: 0
low: -314.885
CAPITAL DEPLOYMENT
 Cash Conversion Ratio 0.282
 CapEx To Revenue -0.0
 CapEx To Depreciation -0.041
 
CAPITAL, LIQUIDITY & COVERAGE CAPITAL STRUCTURE
 Total Capital $ 1.1 B
 Net Invested Capital $ 1.1 B
 Invested Capital $ 1.1 B
 Net Tangible Assets $ 1.1 B
 Net Working Capital $ 738.1 M
LIQUIDITY
 Cash Ratio 12.198
 Current Ratio 12.443
Current Ratio QoQ 0.429 %
Current Ratio YoY -45.731 %
Current Ratio IPRWA high: 24.687
IDYA: 12.443
mean: 4.3
median: 3.195
low: 0.046
 Quick Ratio —
Quick Ratio QoQ —
Quick Ratio YoY —
Quick Ratio IPRWA —
COVERAGE & LEVERAGE
 Debt To EBITDA 0.249
 Cost Of Debt 73.559 %
 Interest Coverage Ratio 4.326
Interest Coverage Ratio QoQ -222.122 %
Interest Coverage Ratio YoY -262.128 %
Interest Coverage Ratio IPRWA high: 815.709
mean: 40.242
IDYA: 4.326
median: 4.213
low: -1538.4
 Operating Cash Flow Ratio 1.882
TIMING / LIQUIDITY
 Days Payables Outstanding (DPO) —
DIVIDENDS
 Dividend Coverage Ratio —
 Dividend Payout Ratio —
 Dividend Rate —
 Dividend Yield —
PERFORMANCE GROWTH
 Asset Growth Rate 13.816 %
 Revenue Growth 2869.057 %
Revenue Growth QoQ —
Revenue Growth YoY —
Revenue Growth IPRWA IDYA: 2869.057 %
high: 301.849 %
mean: 8.057 %
median: 4.118 %
low: -259.856 %
 Earnings Growth -251.136 %
Earnings Growth QoQ -3532.226 %
Earnings Growth YoY 2034.603 %
Earnings Growth IPRWA high: 162.5 %
median: -6.452 %
mean: -13.118 %
low: -198.545 %
IDYA: -251.136 %
MARGINS
 Gross Margin —
Gross Margin QoQ —
Gross Margin YoY —
Gross Margin IPRWA —
 EBIT Margin 52.182 %
EBIT Margin QoQ —
EBIT Margin YoY —
EBIT Margin IPRWA high: 3270.865 %
IDYA: 52.182 %
median: 35.352 %
mean: -114.104 %
low: -8139.786 %
 Return On Sales (ROS) 52.182 %
Return On Sales QoQ —
Return On Sales YoY —
Return On Sales IPRWA high: 70.107 %
IDYA: 52.182 %
median: 26.151 %
mean: -112.075 %
low: -7977.249 %
CASH FLOW
 Free Cash Flow (FCF) $ 142.2 M
 Free Cash Flow Yield 6.014 %
Free Cash Flow Yield QoQ -292.51 %
Free Cash Flow Yield YoY -447.429 %
Free Cash Flow Yield IPRWA high: 30.655 %
IDYA: 6.014 %
median: 0.768 %
mean: 0.299 %
low: -53.991 %
 Free Cash Growth -325.18 %
Free Cash Growth QoQ -13791.789 %
Free Cash Growth YoY -795.186 %
Free Cash Growth IPRWA high: 199.867 %
mean: 28.151 %
median: 21.696 %
low: -198.468 %
IDYA: -325.18 %
 Free Cash To Net Income 1.192
 Cash Flow Margin 58.43 %
 Cash Flow To Earnings 1.018
VALUE & RETURNS
 Economic Value Added $ 0.05
 Return On Assets (ROA) 10.712 %
Return On Assets QoQ -248.038 %
Return On Assets YoY -328.791 %
Return On Assets IPRWA high: 30.5 %
IDYA: 10.712 %
median: -0.016 %
mean: -2.274 %
low: -66.968 %
 Return On Capital Employed (ROCE) 9.678 %
 Return On Equity (ROE) 0.109
Return On Equity QoQ -235.22 %
Return On Equity YoY -348.724 %
Return On Equity IPRWA high: 0.948
IDYA: 0.109
median: -0.002
mean: -0.006
low: -1.385
 DuPont ROE 11.624 %
 Return On Invested Capital (ROIC) 7.846 %
Return On Invested Capital QoQ —
Return On Invested Capital YoY 5.713 %
Return On Invested Capital IPRWA high: 26.519 %
IDYA: 7.846 %
median: 4.232 %
mean: -0.153 %
low: -73.241 %

Six-Week Outlook

Near-term bias favors upside continuation supported by bullish momentum (MACD above its signal and rising RSI) and a strong ADX reading. Price trading above key moving averages and an increasing 12-day EMA reinforces that bias. However, MRO positive suggests price currently exceeds the modeled target and raises the probability of a mean-reversion pullback; proximity to the upper Bollinger band and the 52-week high further increases susceptibility to short-term profit-taking.

Key technical reference levels to monitor include support around the super trend lower $30.39 and the ichimoku Tenkan/Kijun cluster near $31.75/$30.77; sustained momentum above $33.50 would maintain the immediate bullish tilt. Expect elevated volatility given 42-day beta of 1.51 and thinner-than-average daily volume, so plan position durations accordingly and track clinical-data event timing as primary catalysts.

About IDEAYA Biosciences, Inc.

Ideaya Biosciences, Inc. (NASDAQ:IDYA) develops precision medicine solutions in oncology, with a particular emphasis on synthetic lethality, an innovative approach in cancer therapy. Based in South San Francisco, California, the company targets genetically defined patient populations through its pipeline of therapeutic candidates. Notable among these are IDE196, a Phase 2/3 protein kinase C inhibitor for cancers with GNAQ or GNA11 mutations, and IDE397, a Phase 1/2 inhibitor addressing solid tumors with specific gene deletions. Ideaya collaborates with industry leaders such as GlaxoSmithKline, Pfizer, and Novartis, which enhances its drug discovery and development capabilities. The company employs advanced technologies, including the DECIPHER dual CRISPR library and INQUIRE chemical library, to identify new therapeutic targets and biomarkers. Ideaya’s approach to cancer treatment involves not only drug development but also a deep understanding of the genetic and molecular mechanisms of cancer. This strategy aims to provide more effective, personalized therapies, offering new treatment possibilities for patients facing difficult cancer types.



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