Celldex Therapeutics, Inc (NASDAQ:CLDX) Advances Pipeline And Signals Near-Term Momentum Shift

Celldex shows pipeline-driven momentum while fundamental metrics and WMDST valuation flag material downside risk; near-term movement will hinge on clinical readouts and liquidity deployment.

Recent News

On February 26, 2026 the company announced a Phase 3 barzolvolimab milestone that prompted a notable intraday rally. On February 9, 2026 management confirmed planned presentations and investor conference participation through the spring. On March 12, 2026 new Phase 2 and open-label extension data for barzolvolimab in chronic inducible urticaria appeared at the AAAAI meeting, showing rapid clinical improvements on initial and repeat dosing.

Technical Analysis

Directional indicators (ADX/DI+/DI-): ADX at 26.2 indicates a strong trend environment while DI+ at 27.01 declines and DI- shows a dip-and-reversal; together these readings imply recent directional strength with emerging downside pressure that could pressure the premium valuation.

MACD: MACD sits at 1.02 and trends downward below its signal line at 1.06, indicating bearish momentum despite recent price strength; this reduces the probability that momentum will sustain current premium pricing in the near term.

MRO (Momentum/Regression Oscillator): MRO reads 35.31 and is increasing, which implies price sits above WMDST’s target and elevates the likelihood of mean reversion toward valuation levels.

RSI: RSI at 54.45 with a peak-and-reversal pattern signals momentum peaked and has begun to retrace, supporting a near-term consolidation or pullback bias even as the stock trades above short- and medium-term averages.

Price vs. Moving Averages and Bands: Price closed at $30.03, above the 20-day average ($29.87), 50-day average ($26.70), and 200-day average ($24.87), and sits near the 1x upper Bollinger band ($30.73). That positioning underpins the current premium but also limits immediate upside and increases vulnerability to momentum deterioration.

Ichimoku & Support: Tenkan-Sen at $29.95 and Kijun-Sen at $27.22 lie below price, aligning short-term trend support with the super-trend lower level at $27.87; a break below these reference points would materially weaken the technical case for holding premium valuation.

 


Fundamental Analysis

Profitability: Operating income stands at -$87,153,000 and EBIT at -$87,153,000, producing an EBIT margin of -720.27% while EBIT margin improved year-over-year by 14.11 percentage points relative to the prior period; this margin sits far below the industry peer mean of -0.28% and industry peer median of 0.22%.

Revenue and top-line dynamics: Reported total revenue for the period equals $121,000 with revenue down 17.57% quarter-over-quarter but up 32.05% year-over-year; the absolute revenue base remains minimal relative to market capitalization, inflating price-to-sales ratios.

Valuation multiples: P/B registers at 3.18 while the price-to-earnings measures remain negative (PE ratio -20.64) consistent with losses; price-to-sales stands at 13,848.32 and forward price-to-sales at 57,181.49, both well above the industry peer mean of 40.65 and median of 20.21, which underpins WMDST’s assessment that the current valuation classifies the stock as over-valued.

Liquidity and capital structure: Cash and short-term investments total $518,573,000 with cash of $28,871,000 and a cash ratio of 10.17 and current ratio of 10.49, reflecting ample near-term liquidity. Total debt remains minimal at $2,336,000 and debt-to-assets equals 0.40%, indicating a conservative balance sheet that supports continued R&D spending.

Cash flow and R&D investment: Operating cash flow and free cash flow remain negative at -$63,940,000 and -$65,221,000 respectively, while research and development expense totals $75,333,000; sustained negative cash flow ties funding needs to either continued cash reserves or financing activity.

Earnings metrics and guidance context: GAAP EPS for the period equals -$1.22 versus an estimate of -$1.00, producing an EPS surprise of -22.0% relative to the estimate; forward EPS remains negative. These figures, combined with elevated enterprise value and negative margins, reinforce the over-valued designation by WMDST.

Valuation conclusion: WMDST values the stock as over-valued based on extremely high price-to-sales multiples, negative operating margins, and persistent negative cash flow despite a strong cash position and low leverage; clinical progress represents the primary value driver that could materially alter this assessment if it converts to durable commercial potential.

MOST-RECENT QUARTERLY REPORT
REPORT PERIOD ENDING: 2025-12-31
REPORT DATE: 2026-02-25
NEXT REPORT DATE: 2026-05-27
CASH FLOW  Begin Period Cash Flow 36.0 M
 Operating Cash Flow -63.94 M
 Capital Expenditures -1.28 M
 Change In Working Capital 8.5 M
 Dividends Paid
 Cash Flow Delta -7.17 M
 End Period Cash Flow 28.9 M
 
INCOME STATEMENT REVENUE
 Total Revenue 121.0 K
 Forward Revenue 29.3 K
COSTS
 Cost Of Revenue
 Depreciation 816.0 K
 Depreciation and Amortization 816.0 K
 Research and Development 75.3 M
 Total Operating Expenses 87.3 M
PROFITABILITY
 Gross Profit
 EBITDA -86.34 M
 EBIT -87.15 M
 Operating Income -87.15 M
 Interest Income
 Interest Expense
 Net Interest Income
 Income Before Tax -81.32 M
 Tax Provision
 Tax Rate
 Net Income -81.32 M
 Net Income From Continuing Operations -81.32 M
EARNINGS
 EPS Estimate -1.00
 EPS Actual -1.22
 EPS Difference -0.22
 EPS Surprise -22.0 %
 Forward EPS -1.18
 
BALANCE SHEET ASSETS
 Total Assets 583.0 M
 Intangible Assets 27.2 M
 Net Tangible Assets 500.0 M
 Total Current Assets 534.7 M
 Cash and Short-Term Investments 518.6 M
 Cash 28.9 M
 Net Receivables 2.0 M
 Inventory
 Long-Term Investments
LIABILITIES
 Accounts Payable 1.2 M
 Short-Term Debt
 Total Current Liabilities 51.0 M
 Net Debt
 Total Debt 2.3 M
 Total Liabilities 55.8 M
EQUITY
 Total Equity 527.2 M
 Retained Earnings -1.81 B
VALUATION & PER-SHARE METRICS EQUITY & PER-SHARE METRICS
 Book Value Per-Share 7.92
 Shares Outstanding 66.549 M
 Revenue Per-Share 0.00
VALUATION
 Market Capitalization 1.7 B
 Enterprise Value 1.2 B
 Enterprise Multiple -13.429
Enterprise Multiple QoQ -8.87 %
Enterprise Multiple YoY -19.417 %
Enterprise Multiple IPRWA high: 102.834
median: 58.093
mean: 22.902
CLDX: -13.429
low: -145.027
 EV/R 9581.896
CAPITAL STRUCTURE
 Asset To Equity 1.106
 Asset To Liability 10.444
 Debt To Capital 0.004
 Debt To Assets 0.004
Debt To Assets QoQ -0.743 %
Debt To Assets YoY -16.632 %
Debt To Assets IPRWA high: 0.934
mean: 0.254
median: 0.191
CLDX: 0.004
low: 0.0
 Debt To Equity 0.004
Debt To Equity QoQ 1.142 %
Debt To Equity YoY -13.137 %
Debt To Equity IPRWA high: 1.62
mean: 0.398
median: 0.109
CLDX: 0.004
low: -1.035
PRICE-BASED VALUATION
 Price To Book (P/B) 3.179
Price To Book QoQ 15.041 %
Price To Book YoY 44.65 %
Price To Book IPRWA high: 20.409
mean: 7.941
median: 6.164
CLDX: 3.179
low: -10.511
 Price To Earnings (P/E) -20.639
Price To Earnings QoQ -16.223 %
Price To Earnings YoY -40.749 %
Price To Earnings IPRWA high: 105.518
median: 53.472
mean: 15.661
CLDX: -20.639
low: -145.713
 PE/G Ratio -0.993
 Price To Sales (P/S) 13848.317
Price To Sales QoQ
Price To Sales YoY 891.277 %
Price To Sales IPRWA CLDX: 13848.317
high: 438.506
mean: 40.653
median: 20.207
low: -75.758
FORWARD MULTIPLES
Forward P/E -22.006
Forward PE/G -1.058
Forward P/S 57181.491
EFFICIENCY OPERATIONAL
 Operating Leverage
ASSET & SALES
 Asset Turnover Ratio 0.0
Asset Turnover Ratio QoQ
Asset Turnover Ratio YoY -86.207 %
Asset Turnover Ratio IPRWA high: 0.406
mean: 0.117
median: 0.109
CLDX: 0.0
low: -0.066
 Receivables Turnover 0.115
Receivables Turnover Ratio QoQ
Receivables Turnover Ratio YoY -92.408 %
Receivables Turnover Ratio IPRWA high: 5.263
mean: 1.429
median: 1.333
CLDX: 0.115
low: -1.505
 Inventory Turnover
Inventory Turnover Ratio QoQ
Inventory Turnover Ratio YoY
Inventory Turnover Ratio IPRWA
 Days Sales Outstanding (DSO) 793.724
CASH CYCLE
 Cash Conversion Cycle Days (CCC) 793.724
Cash Conversion Cycle Days QoQ
Cash Conversion Cycle Days YoY
Cash Conversion Cycle Days IPRWA high: 937.301
CLDX: 793.724
mean: 198.705
median: 192.562
low: -928.365
CAPITAL DEPLOYMENT
 Cash Conversion Ratio 0.0
 CapEx To Revenue -10.587
 CapEx To Depreciation -1.57
 
CAPITAL, LIQUIDITY & COVERAGE CAPITAL STRUCTURE
 Total Capital 527.2 M
 Net Invested Capital 527.2 M
 Invested Capital 527.2 M
 Net Tangible Assets 500.0 M
 Net Working Capital 483.7 M
LIQUIDITY
 Cash Ratio 10.17
 Current Ratio 10.485
Current Ratio QoQ -19.382 %
Current Ratio YoY -44.565 %
Current Ratio IPRWA high: 30.664
CLDX: 10.485
mean: 5.471
median: 2.901
low: 0.35
 Quick Ratio
Quick Ratio QoQ
Quick Ratio YoY
Quick Ratio IPRWA
COVERAGE & LEVERAGE
 Debt To EBITDA -0.027
 Cost Of Debt 125.479 %
 Interest Coverage Ratio -28.023
Interest Coverage Ratio QoQ 18.387 %
Interest Coverage Ratio YoY 55.555 %
Interest Coverage Ratio IPRWA high: 404.333
mean: 39.978
median: 3.319
CLDX: -28.023
low: -696.975
 Operating Cash Flow Ratio -1.677
TIMING / LIQUIDITY
 Days Payables Outstanding (DPO)
DIVIDENDS
 Dividend Coverage Ratio
 Dividend Payout Ratio
 Dividend Rate
 Dividend Yield
PERFORMANCE GROWTH
 Asset Growth Rate -10.094 %
 Revenue Growth -83.425 %
Revenue Growth QoQ -1756.573 %
Revenue Growth YoY 32.048 %
Revenue Growth IPRWA high: 280.972 %
mean: 13.198 %
median: 3.233 %
CLDX: -83.425 %
low: -200.0 %
 Earnings Growth 20.792 %
Earnings Growth QoQ 10.455 %
Earnings Growth YoY 90.107 %
Earnings Growth IPRWA high: 203.846 %
CLDX: 20.792 %
mean: -21.179 %
median: -28.395 %
low: -250.0 %
MARGINS
 Gross Margin
Gross Margin QoQ
Gross Margin YoY
Gross Margin IPRWA
 EBIT Margin -72027.273 %
EBIT Margin QoQ
EBIT Margin YoY 1410.558 %
EBIT Margin IPRWA high: 1116.376 %
median: 21.964 %
mean: -27.871 %
low: -2169.55 %
CLDX: -72027.273 %
 Return On Sales (ROS) -72027.273 %
Return On Sales QoQ
Return On Sales YoY 1410.558 %
Return On Sales IPRWA high: 1116.376 %
median: 27.569 %
mean: -28.614 %
low: -2536.231 %
CLDX: -72027.273 %
CASH FLOW
 Free Cash Flow (FCF) -65.22 M
 Free Cash Flow Yield -3.892 %
Free Cash Flow Yield QoQ 31.132 %
Free Cash Flow Yield YoY 92.292 %
Free Cash Flow Yield IPRWA high: 19.179 %
mean: 0.331 %
median: 0.303 %
CLDX: -3.892 %
low: -30.203 %
 Free Cash Growth 32.92 %
Free Cash Growth QoQ 239.697 %
Free Cash Growth YoY -181.22 %
Free Cash Growth IPRWA high: 205.565 %
CLDX: 32.92 %
median: -24.801 %
mean: -28.08 %
low: -220.947 %
 Free Cash To Net Income 0.802
 Cash Flow Margin -70671.901 %
 Cash Flow To Earnings 1.052
VALUE & RETURNS
 Economic Value Added
 Return On Assets (ROA) -13.207 %
Return On Assets QoQ 32.07 %
Return On Assets YoY 126.535 %
Return On Assets IPRWA high: 27.866 %
median: 1.475 %
mean: -1.853 %
CLDX: -13.207 %
low: -47.9 %
 Return On Capital Employed (ROCE) -16.382 %
 Return On Equity (ROE) -0.154
Return On Equity QoQ 37.662 %
Return On Equity YoY 144.686 %
Return On Equity IPRWA high: 0.657
median: 0.055
mean: 0.017
CLDX: -0.154
low: -0.879
 DuPont ROE -14.705 %
 Return On Invested Capital (ROIC)
Return On Invested Capital QoQ
Return On Invested Capital YoY
Return On Invested Capital IPRWA

Six-Week Outlook

Expect elevated volatility and event-driven swings over the next six weeks. Technical momentum shows weakening: MACD below its signal line and RSI peaking point to increased downside susceptibility, while MRO indicates price sits above valuation and favors mean reversion. Liquidity and minimal debt reduce immediate solvency risk, but fundamentals do not support the current premium; therefore, price action will likely hinge on further clinical updates or clarifying news about capital allocation. Traders should monitor short-term support near $27.80–$28.00 (super trend lower and Kijun-Sen) and watch for sustained MACD recovery above its signal line or a decisive breakdown below the short-term support to reassess directional bias.

About Celldex Therapeutics, Inc.

Celldex Therapeutics, Inc. (NASDAQ:CLDX) develops advanced antibody-based therapeutics aimed at treating inflammatory, allergic, autoimmune, and other severe diseases. The company focuses on creating innovative monoclonal and bispecific antibodies, with a notable emphasis on CDX-0159, a Phase II monoclonal antibody targeting the receptor tyrosine kinase KIT. This therapeutic candidate holds potential for addressing challenging medical conditions. Founded in 1983, Celldex maintains its headquarters in Hampton, New Jersey. The company leverages cutting-edge scientific research to address unmet medical needs, collaborating with renowned institutions such as Yale University. These partnerships enhance Celldex’s research capabilities and expedite the development of its therapeutic candidates. Celldex Therapeutics actively contributes to the biopharmaceutical industry through strategic partnerships and a strong research framework. The company remains dedicated to improving patient outcomes and quality of life worldwide by developing transformative treatments.



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